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Abnormal fecal pH

MedGen UID:
1707402
•Concept ID:
C5139379
•
Finding
Synonym: Abnormal faecal pH
 
HPO: HP:0032488

Definition

Any deviation from the normal pH of feces. The pH reflects the acidity or alkalinity of a solution on a logarithmic scale on which 7 is neutral, whereby lower values are more acid and higher values more alkaline. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal fecal pH

Professional guidelines

PubMed

Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment.
Guo XY, Liu XJ, Hao JY
J Dig Dis 2020 Mar;21(3):147-159. doi: 10.1111/1751-2980.12849. PMID: 32040250
Acute Management of Hyperkalemia.
Liu M, Rafique Z
Curr Heart Fail Rep 2019 Jun;16(3):67-74. doi: 10.1007/s11897-019-00425-2. PMID: 30972536
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066

Recent clinical studies

Etiology

Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.
Yang J, Hou L, Wang J, Xiao L, Zhang J, Yin N, Yao S, Cheng K, Zhang W, Shi Z, Wang J, Jiang H, Huang N, You Y, Lin M, Shang R, Wei Y, Zhao Y, Zhao F
Gut 2022 Dec;71(12):2451-2462. Epub 2022 Apr 6 doi: 10.1136/gutjnl-2021-326482. PMID: 35387876Free PMC Article
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota.
Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S
Alzheimers Dement 2019 Oct;15(10):1357-1366. Epub 2019 Aug 18 doi: 10.1016/j.jalz.2019.07.002. PMID: 31434623
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW
Cell 2015 Jan 29;160(3):447-60. Epub 2015 Jan 22 doi: 10.1016/j.cell.2015.01.002. PMID: 25619688Free PMC Article

Diagnosis

Integrated Analysis of Colorectal Cancer Reveals Cross-Cohort Gut Microbial Signatures and Associated Serum Metabolites.
Gao R, Wu C, Zhu Y, Kong C, Zhu Y, Gao Y, Zhang X, Yang R, Zhong H, Xiong X, Chen C, Xu Q, Qin H
Gastroenterology 2022 Oct;163(4):1024-1037.e9. Epub 2022 Jul 1 doi: 10.1053/j.gastro.2022.06.069. PMID: 35788345
Staging exocrine pancreatic dysfunction.
Khan A, Vege SS, Dudeja V, Chari ST
Pancreatology 2022 Jan;22(1):168-172. Epub 2021 Nov 19 doi: 10.1016/j.pan.2021.11.005. PMID: 34916141
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota.
Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S
Alzheimers Dement 2019 Oct;15(10):1357-1366. Epub 2019 Aug 18 doi: 10.1016/j.jalz.2019.07.002. PMID: 31434623
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L
Science 2018 Jan 5;359(6371):91-97. Epub 2017 Nov 2 doi: 10.1126/science.aan3706. PMID: 29097494
Meconium ileus.
Ziegler MM
Curr Probl Surg 1994 Sep;31(9):731-77. doi: 10.1016/0011-3840(94)90040-x. PMID: 8062591

Therapy

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
Kang DW, Adams JB, Coleman DM, Pollard EL, Maldonado J, McDonough-Means S, Caporaso JG, Krajmalnik-Brown R
Sci Rep 2019 Apr 9;9(1):5821. doi: 10.1038/s41598-019-42183-0. PMID: 30967657Free PMC Article
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L
Science 2018 Jan 5;359(6371):91-97. Epub 2017 Nov 2 doi: 10.1126/science.aan3706. PMID: 29097494
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.
Kang DW, Adams JB, Gregory AC, Borody T, Chittick L, Fasano A, Khoruts A, Geis E, Maldonado J, McDonough-Means S, Pollard EL, Roux S, Sadowsky MJ, Lipson KS, Sullivan MB, Caporaso JG, Krajmalnik-Brown R
Microbiome 2017 Jan 23;5(1):10. doi: 10.1186/s40168-016-0225-7. PMID: 28122648Free PMC Article
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E
Nature 2014 Oct 9;514(7521):181-6. Epub 2014 Sep 17 doi: 10.1038/nature13793. PMID: 25231862

Prognosis

Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.
Du X, Yang L, Kong L, Sun Y, Shen K, Cai Y, Sun H, Zhang B, Guo S, Zhang A, Wang X
Front Endocrinol (Lausanne) 2022;13:1037164. Epub 2022 Oct 27 doi: 10.3389/fendo.2022.1037164. PMID: 36387907Free PMC Article
A finger in every pie - The versatility of chemokines.
Kattner AA
Biomed J 2022 Jun;45(3):427-431. Epub 2022 Jun 10 doi: 10.1016/j.bj.2022.06.001. PMID: 35697204Free PMC Article
Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
Kang DW, Adams JB, Coleman DM, Pollard EL, Maldonado J, McDonough-Means S, Caporaso JG, Krajmalnik-Brown R
Sci Rep 2019 Apr 9;9(1):5821. doi: 10.1038/s41598-019-42183-0. PMID: 30967657Free PMC Article
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Clinical practice. Protein-losing enteropathy in children.
Braamskamp MJ, Dolman KM, Tabbers MM
Eur J Pediatr 2010 Oct;169(10):1179-85. Epub 2010 Jun 23 doi: 10.1007/s00431-010-1235-2. PMID: 20571826Free PMC Article

Clinical prediction guides

Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
Zeng Q, Li D, He Y, Li Y, Yang Z, Zhao X, Liu Y, Wang Y, Sun J, Feng X, Wang F, Chen J, Zheng Y, Yang Y, Sun X, Xu X, Wang D, Kenney T, Jiang Y, Gu H, Li Y, Zhou K, Li S, Dai W
Sci Rep 2019 Sep 17;9(1):13424. doi: 10.1038/s41598-019-49462-w. PMID: 31530820Free PMC Article
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota.
Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S
Alzheimers Dement 2019 Oct;15(10):1357-1366. Epub 2019 Aug 18 doi: 10.1016/j.jalz.2019.07.002. PMID: 31434623
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LAB, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ
Cell 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. PMID: 27814509Free PMC Article
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
Norman JM, Handley SA, Baldridge MT, Droit L, Liu CY, Keller BC, Kambal A, Monaco CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DP, Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier RJ, Wang D, Parkes M, Virgin HW
Cell 2015 Jan 29;160(3):447-60. Epub 2015 Jan 22 doi: 10.1016/j.cell.2015.01.002. PMID: 25619688Free PMC Article

Recent systematic reviews

Post-operative colonic manometry in children with Hirschsprung disease: A systematic review.
Evans-Barns HME, Swannjo J, Trajanovska M, Safe M, Hutson JM, Teague WJ, Dinning PG, King SK
Neurogastroenterol Motil 2021 Nov;33(11):e14201. Epub 2021 Jul 2 doi: 10.1111/nmo.14201. PMID: 34214244
Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis.
Dai Y, Deng Y, Lin Y, Ouyang R, Li L
BMC Gastroenterol 2020 Mar 12;20(1):67. doi: 10.1186/s12876-020-01208-z. PMID: 32164539Free PMC Article
Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review.
Sharma P, Baloda V, Gahlot GP, Singh A, Mehta R, Vishnubathla S, Kapoor K, Ahuja V, Gupta SD, Makharia GK, Das P
J Gastroenterol Hepatol 2019 Jan;34(1):74-83. Epub 2018 Aug 30 doi: 10.1111/jgh.14403. PMID: 30069926
To ignore or not to ignore placental calcifications on prenatal ultrasound: a systematic review and meta-analysis.
Mirza FG, Ghulmiyyah LM, Tamim H, Makki M, Jeha D, Nassar A
J Matern Fetal Neonatal Med 2018 Mar;31(6):797-804. Epub 2017 Mar 6 doi: 10.1080/14767058.2017.1295443. PMID: 28264638
The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review.
Rutayisire E, Huang K, Liu Y, Tao F
BMC Gastroenterol 2016 Jul 30;16(1):86. doi: 10.1186/s12876-016-0498-0. PMID: 27475754Free PMC Article

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