U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cutaneous Indeterminate Dendritic Cell Tumor

MedGen UID:
1709305
•Concept ID:
C5239288
•
Neoplastic Process
Synonym: Cutaneous Indeterminate Cell Histiocytosis

Definition

A very rare dendritic cell tumor affecting the skin. It is composed of spindle to ovoid cells with a phenotype that is similar to the Langerhans cells. It manifests with cutaneous papules, nodules, and plaques. The clinical course is variable. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Indeterminate Dendritic Cell Tumor

Recent clinical studies

Etiology

Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation.
Santos-Briz A, Román C, Corral R, de Dios A, Vázquez L, Ludeña MD
Am J Dermatopathol 2017 Sep;39(9):696-699. doi: 10.1097/DAD.0000000000000935. PMID: 28825606
Specific skin lesions in chronic myelomonocytic leukemia: a spectrum of myelomonocytic and dendritic cell proliferations: a study of 42 cases.
Vitte F, Fabiani B, Bénet C, Dalac S, Balme B, Delattre C, Vergier B, Beylot-Barry M, Vignon-Pennamen D, Ortonne N, Algros MP, Carlotti A, Samaleire D, Frouin E, Levy A, Laroche L, Theate I, Monnien F, Mugneret F, Petrella T
Am J Surg Pathol 2012 Sep;36(9):1302-16. doi: 10.1097/PAS.0b013e31825dd4de. PMID: 22895265

Diagnosis

A Case of Indeterminate Cutaneous Dendritic Cell Tumors in the Setting of Chronic Myelomonocytic Leukemia.
Nyckowski T, Vance P, Marks E
Am J Dermatopathol 2022 Jun 1;44(6):449-453. Epub 2022 Apr 6 doi: 10.1097/DAD.0000000000002195. PMID: 35385851
Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA
Am J Dermatopathol 2018 Oct;40(10):736-748. doi: 10.1097/DAD.0000000000001191. PMID: 29877893
Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite.
Mo X, Guo W, Ye H
Medicine (Baltimore) 2015 Aug;94(34):e1443. doi: 10.1097/MD.0000000000001443. PMID: 26313805Free PMC Article
Indeterminate cell tumor: a rare dendritic neoplasm.
Rezk SA, Spagnolo DV, Brynes RK, Weiss LM
Am J Surg Pathol 2008 Dec;32(12):1868-76. doi: 10.1097/PAS.0b013e31818593d6. PMID: 18813122
Cutaneous indeterminate cell histiocytosis: a new spindle cell variant resembling dendritic cell sarcoma.
Rosenberg AS, Morgan MB
J Cutan Pathol 2001 Nov;28(10):531-7. doi: 10.1034/j.1600-0560.2001.281007.x. PMID: 11737523

Therapy

Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation.
Santos-Briz A, Román C, Corral R, de Dios A, Vázquez L, Ludeña MD
Am J Dermatopathol 2017 Sep;39(9):696-699. doi: 10.1097/DAD.0000000000000935. PMID: 28825606

Prognosis

Atypical cutaneous histiocytic eruption in a patient with chronic myelomonocytic leukemia: A case report.
Li JJ, Talam S, Star P, Getta B
J Cutan Pathol 2021 May;48(5):680-688. Epub 2021 Jan 20 doi: 10.1111/cup.13957. PMID: 33416192
Blastic plasmacytoid dendritic cell neoplasm with unusual extracutaneous manifestation: Two case reports and literature review.
Lee SE, Park HY, Kwon D, Jeon YK, Kim WY
Medicine (Baltimore) 2019 Feb;98(6):e14344. doi: 10.1097/MD.0000000000014344. PMID: 30732162Free PMC Article
Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA
Am J Dermatopathol 2018 Oct;40(10):736-748. doi: 10.1097/DAD.0000000000001191. PMID: 29877893
Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite.
Mo X, Guo W, Ye H
Medicine (Baltimore) 2015 Aug;94(34):e1443. doi: 10.1097/MD.0000000000001443. PMID: 26313805Free PMC Article
Specific skin lesions in chronic myelomonocytic leukemia: a spectrum of myelomonocytic and dendritic cell proliferations: a study of 42 cases.
Vitte F, Fabiani B, Bénet C, Dalac S, Balme B, Delattre C, Vergier B, Beylot-Barry M, Vignon-Pennamen D, Ortonne N, Algros MP, Carlotti A, Samaleire D, Frouin E, Levy A, Laroche L, Theate I, Monnien F, Mugneret F, Petrella T
Am J Surg Pathol 2012 Sep;36(9):1302-16. doi: 10.1097/PAS.0b013e31825dd4de. PMID: 22895265

Clinical prediction guides

Blastic plasmacytoid dendritic cell neoplasm with unusual extracutaneous manifestation: Two case reports and literature review.
Lee SE, Park HY, Kwon D, Jeon YK, Kim WY
Medicine (Baltimore) 2019 Feb;98(6):e14344. doi: 10.1097/MD.0000000000014344. PMID: 30732162Free PMC Article
Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA
Am J Dermatopathol 2018 Oct;40(10):736-748. doi: 10.1097/DAD.0000000000001191. PMID: 29877893
Self-regressing S100-negative CD1a-positive cutaneous histiocytosis.
Tardío JC, Aguado M, Borbujo J
Am J Dermatopathol 2013 Jun;35(4):e57-9. doi: 10.1097/DAD.0b013e31827adc72. PMID: 23334517
Prolonged viability of human skin xenografts in rats by cyclosporine.
Biren CA, Barr RJ, McCullough JL, Black KS, Hewitt CW
J Invest Dermatol 1986 Jun;86(6):611-4. doi: 10.1111/1523-1747.ep12275576. PMID: 3519782
The relationship between T lymphocyte subsets and Ia-like antigen positive nonlymphoid cells in early stages of cutaneous T cell lymphoma.
Thomas JA, Janossy G, Graham-Brown RA, Kung PC, Goldstein G
J Invest Dermatol 1982 Feb;78(2):169-76. doi: 10.1111/1523-1747.ep12506339. PMID: 7035573

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...