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Metastatic Digestive System Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
1709653
•Concept ID:
C5235856
•
Neoplastic Process

Definition

Mixed adenoneuroendocrine carcinoma that arises from the digestive system and has metastasized to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Digestive System Mixed Adenoneuroendocrine Carcinoma

Recent clinical studies

Etiology

Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.
Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z, Sun Y, Li Y, Zhou J, Wang X, Peng Z, Shen L, Lu M
Cancer Med 2021 Jul;10(14):4855-4863. Epub 2021 Jun 10 doi: 10.1002/cam4.4031. PMID: 34109756Free PMC Article
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours.
Kim J, Lee WJ, Lee SH, Lee KB, Ryu JK, Kim YT, Kim SW, Yoon YB, Hwang JH, Han HS, Woo SM, Park SJ
Dig Liver Dis 2011 Dec;43(12):965-70. doi: 10.1016/j.dld.2011.07.010. PMID: 21856258

Diagnosis

Focal neuroendocrine carcinoma mixed with adenocarcinoma of the gallbladder with aggressive lymph node metastasis in a patient who did not meet the mixed neuroendocrine-non-neuroendocrine neoplasm criteria.
Kadota Y, Funakoshi S, Hirose S, Shiomi E, Odaira M, Yagishita H, Kobayashi Y, Toriumi F, Tamai S, Endo T, Harada H
Clin J Gastroenterol 2022 Feb;15(1):185-191. Epub 2021 Nov 12 doi: 10.1007/s12328-021-01547-8. PMID: 34767241Free PMC Article
Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis.
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038
Metastatic Mixed Adeno-Neuroendocrine Carcinoma of the Colon to the Liver with Multiple Peritoneal Deposits: A Case Report.
AlQattan AS, AlSulaiman NS, AlDossary MY, AlSomali M, Alshammari T
Am J Case Rep 2021 Apr 15;22:e929099. doi: 10.12659/AJCR.929099. PMID: 33857061Free PMC Article
Cytological findings of appendiceal mixed adenoneuroendocrine carcinoma in pleural effusion: Morphological changes evident after metastasis.
Tonooka A, Oda K, Hayashi M, Sakazume K, Tanaka H, Kaburaki KH, Uekusa T
Diagn Cytopathol 2015 Jul;43(7):577-80. Epub 2014 Nov 26 doi: 10.1002/dc.23236. PMID: 25425263
Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla: two case reports with review of literature.
Zhang L, DeMay RM
Diagn Cytopathol 2014 Dec;42(12):1075-84. Epub 2014 Feb 19 doi: 10.1002/dc.23107. PMID: 24554593

Therapy

A Rare Case of Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gastroesophageal Junction with HER2/neu Overexpression and Distinct Orbital and Optic Nerve Toxicity after Intravenous Administration of Cisplatin.
Golombek T, Henker R, Rehak M, Quäschling U, Lordick F, Knödler M
Oncol Res Treat 2019;42(3):123-127. Epub 2019 Feb 23 doi: 10.1159/000495218. PMID: 30799422
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Two cases of neuroendocrine carcinoma of the gallbladder.
Chen H, Shen YY, Ni XZ
World J Gastroenterol 2014 Sep 7;20(33):11916-20. doi: 10.3748/wjg.v20.i33.11916. PMID: 25206300Free PMC Article

Prognosis

Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis.
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038
A Rare Case of Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gastroesophageal Junction with HER2/neu Overexpression and Distinct Orbital and Optic Nerve Toxicity after Intravenous Administration of Cisplatin.
Golombek T, Henker R, Rehak M, Quäschling U, Lordick F, Knödler M
Oncol Res Treat 2019;42(3):123-127. Epub 2019 Feb 23 doi: 10.1159/000495218. PMID: 30799422
Cytological findings of appendiceal mixed adenoneuroendocrine carcinoma in pleural effusion: Morphological changes evident after metastasis.
Tonooka A, Oda K, Hayashi M, Sakazume K, Tanaka H, Kaburaki KH, Uekusa T
Diagn Cytopathol 2015 Jul;43(7):577-80. Epub 2014 Nov 26 doi: 10.1002/dc.23236. PMID: 25425263
Two cases of neuroendocrine carcinoma of the gallbladder.
Chen H, Shen YY, Ni XZ
World J Gastroenterol 2014 Sep 7;20(33):11916-20. doi: 10.3748/wjg.v20.i33.11916. PMID: 25206300Free PMC Article
Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours.
Kim J, Lee WJ, Lee SH, Lee KB, Ryu JK, Kim YT, Kim SW, Yoon YB, Hwang JH, Han HS, Woo SM, Park SJ
Dig Liver Dis 2011 Dec;43(12):965-70. doi: 10.1016/j.dld.2011.07.010. PMID: 21856258

Clinical prediction guides

Focal neuroendocrine carcinoma mixed with adenocarcinoma of the gallbladder with aggressive lymph node metastasis in a patient who did not meet the mixed neuroendocrine-non-neuroendocrine neoplasm criteria.
Kadota Y, Funakoshi S, Hirose S, Shiomi E, Odaira M, Yagishita H, Kobayashi Y, Toriumi F, Tamai S, Endo T, Harada H
Clin J Gastroenterol 2022 Feb;15(1):185-191. Epub 2021 Nov 12 doi: 10.1007/s12328-021-01547-8. PMID: 34767241Free PMC Article
Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.
Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z, Sun Y, Li Y, Zhou J, Wang X, Peng Z, Shen L, Lu M
Cancer Med 2021 Jul;10(14):4855-4863. Epub 2021 Jun 10 doi: 10.1002/cam4.4031. PMID: 34109756Free PMC Article
Two cases of neuroendocrine carcinoma of the gallbladder.
Chen H, Shen YY, Ni XZ
World J Gastroenterol 2014 Sep 7;20(33):11916-20. doi: 10.3748/wjg.v20.i33.11916. PMID: 25206300Free PMC Article

Recent systematic reviews

Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis.
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038

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