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Skin Squamous Cell Carcinoma with Sarcomatoid Differentiation

MedGen UID:
1710338
•Concept ID:
C5237208
•
Neoplastic Process
Synonyms: Skin Carcinosarcoma; Skin Metaplastic Carcinoma; Skin Pseudosarcomatous Squamous Cell Carcinoma; Skin Sarcomatoid Squamous Cell Carcinoma

Definition

A rare carcinoma of the skin characterized by the presence of squamous cell carcinomatous and sarcomatous components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Squamous Cell Carcinoma with Sarcomatoid Differentiation

Professional guidelines

PubMed

CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma.
Kanner WA, Brill LB 2nd, Patterson JW, Wick MR
J Cutan Pathol 2010 Jul;37(7):744-50. Epub 2010 Feb 24 doi: 10.1111/j.1600-0560.2010.01534.x. PMID: 20184665

Recent clinical studies

Etiology

Expression of SATB2 in primary cutaneous sarcomatoid neoplasms: a potential diagnostic pitfall.
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
CD10 immunoreactivity in sarcomatoid carcinomas: comparison with true sarcomas.
Vennapusa B, Fischer EG, Wick MR, Cerilli LA
Appl Immunohistochem Mol Morphol 2011 Oct;19(5):408-12. doi: 10.1097/PAI.0b013e3182111be5. PMID: 21908981
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma.
Wieland CN, Dyck R, Weenig RH, Comfere NI
J Cutan Pathol 2011 Nov;38(11):884-8. Epub 2011 Aug 23 doi: 10.1111/j.1600-0560.2011.01768.x. PMID: 21883368
Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature.
Patel NK, McKee PH, Smith NP, Fletcher CD
Am J Dermatopathol 1997 Aug;19(4):363-72. doi: 10.1097/00000372-199708000-00008. PMID: 9261471
Cutaneous sarcomas and sarcomatoid neoplasms of the skin.
Wick MR, Fitzgibbon J, Swanson PE
Semin Diagn Pathol 1993 May;10(2):148-58. PMID: 8396271

Diagnosis

Expression of SATB2 in primary cutaneous sarcomatoid neoplasms: a potential diagnostic pitfall.
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
Sarcomatoid Carcinoma With Quasi-Complete Loss of Cytokeratin Expression or Keratin-Positive Atypical Fibroxanthoma.
Roy SF, Lafaille P, Désy D
Int J Surg Pathol 2019 Aug;27(5):518-520. Epub 2019 Feb 14 doi: 10.1177/1066896919830208. PMID: 30760056
Expression of the p40 isoform of p63 has high specificity for cutaneous sarcomatoid squamous cell carcinoma.
Ha Lan TT, Chen SJ, Arps DP, Fullen DR, Patel RM, Siddiqui J, Carskadon S, Palanisamy N, Harms PW
J Cutan Pathol 2014 Nov;41(11):831-8. Epub 2014 Nov 3 doi: 10.1111/cup.12387. PMID: 25263756
Sarcomatoid squamous cell carcinoma: a long-standing case.
Singh RS, Bhattacharjee PB, Youngberg GA, Al-Abbadi MA
Acta Dermatovenerol Alp Pannonica Adriat 2008 Dec;17(4):185-7. PMID: 19104745
Cutaneous sarcomas and sarcomatoid neoplasms of the skin.
Wick MR, Fitzgibbon J, Swanson PE
Semin Diagn Pathol 1993 May;10(2):148-58. PMID: 8396271

Therapy

Tertiary lymphoid structures with overlapping histopathologic features of cutaneous marginal zone lymphoma during neoadjuvant cemiplimab therapy are associated with antitumor response.
Sweeney KJ, Tetzlaff MT, Vega F, Gillenwater A, Zuo Z, Gross N, Nagarajan P, Wargo J, Nelson K, Prieto VG, Torres-Cabala CA, Curry JL
J Cutan Pathol 2021 May;48(5):674-679. Epub 2021 Jan 13 doi: 10.1111/cup.13953. PMID: 33399228
A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations.
Miller TI, Zoumberos NA, Johnson B, Rhodes DR, Tomlins SA, Chan MP, Andea AA, Lucas DR, McHugh JB, Smith N, Harms KL, Brewer C, Saleh J, Patel RM, Harms PW
Hum Pathol 2020 Aug;102:60-69. Epub 2020 Jun 12 doi: 10.1016/j.humpath.2020.06.003. PMID: 32540221
Concurrent basal cell and squamous cell carcinomas associated with hydroxyurea therapy.
Radić J, Batinac T, Hadžisejdić I, Načinović-Duletić A, Valković T, Jonjić N
Acta Dermatovenerol Croat 2011;19(3):183-6. PMID: 21933645

Prognosis

A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations.
Miller TI, Zoumberos NA, Johnson B, Rhodes DR, Tomlins SA, Chan MP, Andea AA, Lucas DR, McHugh JB, Smith N, Harms KL, Brewer C, Saleh J, Patel RM, Harms PW
Hum Pathol 2020 Aug;102:60-69. Epub 2020 Jun 12 doi: 10.1016/j.humpath.2020.06.003. PMID: 32540221
Sarcomatoid Carcinoma With Quasi-Complete Loss of Cytokeratin Expression or Keratin-Positive Atypical Fibroxanthoma.
Roy SF, Lafaille P, Désy D
Int J Surg Pathol 2019 Aug;27(5):518-520. Epub 2019 Feb 14 doi: 10.1177/1066896919830208. PMID: 30760056
Metastatic Sarcomatoid Lung Cancer: A Rare Cutaneous Spindle Cell Neoplasm.
Yu J, Plaza JA, Schieke SM
Am J Dermatopathol 2016 Mar;38(3):e36-9. doi: 10.1097/DAD.0000000000000411. PMID: 26894781
Sarcoma-like tumor of head and neck skin.
Nonaka D, Bishop PW
Am J Surg Pathol 2014 Jul;38(7):956-65. doi: 10.1097/PAS.0000000000000210. PMID: 24705313
Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature.
Patel NK, McKee PH, Smith NP, Fletcher CD
Am J Dermatopathol 1997 Aug;19(4):363-72. doi: 10.1097/00000372-199708000-00008. PMID: 9261471

Clinical prediction guides

Expression of SATB2 in primary cutaneous sarcomatoid neoplasms: a potential diagnostic pitfall.
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
Manifestation of osteoblastic phenotypes in the sarcomatous component of epithelial carcinoma and sarcomatoid carcinoma.
Takashima Y, Murakami T, Inoue T, Hagiyama M, Yoneshige A, Nishimura S, Akagi M, Ito A
Tumour Biol 2017 Jun;39(6):1010428317704365. doi: 10.1177/1010428317704365. PMID: 28651491
A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.
Cantariño N, Fernández-Figueras MT, Valero V, Musulén E, Malinverni R, Granada I, Goldie SJ, Martín-Caballero J, Douet J, Forcales SV, Buschbeck M
Int J Cancer 2016 Sep 1;139(5):1106-16. Epub 2016 May 5 doi: 10.1002/ijc.30139. PMID: 27074337
CD10 immunoreactivity in sarcomatoid carcinomas: comparison with true sarcomas.
Vennapusa B, Fischer EG, Wick MR, Cerilli LA
Appl Immunohistochem Mol Morphol 2011 Oct;19(5):408-12. doi: 10.1097/PAI.0b013e3182111be5. PMID: 21908981
The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma.
Wieland CN, Dyck R, Weenig RH, Comfere NI
J Cutan Pathol 2011 Nov;38(11):884-8. Epub 2011 Aug 23 doi: 10.1111/j.1600-0560.2011.01768.x. PMID: 21883368

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