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Neonatal bilateral asymmetric tonic seizure

MedGen UID:
1710907
•Concept ID:
C5397837
•
Disease or Syndrome
HPO: HP:0032831

Definition

Neonatal bilateral asymmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body but asymmetrically. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal bilateral asymmetric tonic seizure

Recent clinical studies

Etiology

Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
El Atrache R, Tamilia E, Amengual-Gual M, Mohammadpour Touserkani F, Yang Y, Wang X, Ufongene C, Sheehan T, Cantley S, Jackson M, Zhang B, Papadelis C, Sarkis RA, Loddenkemper T
Epilepsy Behav 2021 Sep;122:108228. Epub 2021 Aug 10 doi: 10.1016/j.yebeh.2021.108228. PMID: 34388667
Age-dependent semiology of frontal lobe seizures.
Hintz M, Krenz V, Schulze-Bonhage A
Epilepsy Res 2019 Jan;149:83-87. Epub 2018 Oct 23 doi: 10.1016/j.eplepsyres.2018.10.007. PMID: 30529718
Rapid and safe response to low-dose carbamazepine in neonatal epilepsy.
Sands TT, Balestri M, Bellini G, Mulkey SB, Danhaive O, Bakken EH, Taglialatela M, Oldham MS, Vigevano F, Holmes GL, Cilio MR
Epilepsia 2016 Dec;57(12):2019-2030. Epub 2016 Nov 26 doi: 10.1111/epi.13596. PMID: 27888506
A long-term, clinical study on symptomatic infantile spasms with focal features.
Fujii A, Oguni H, Hirano Y, Shioda M, Osawa M
Brain Dev 2013 May;35(5):379-85. Epub 2012 Aug 11 doi: 10.1016/j.braindev.2012.06.008. PMID: 22889572
Absence seizures in the first 3 years of life: an electroclinical study of 46 cases.
Caraballo RH, Darra F, Fontana E, Garcia R, Monese E, Dalla Bernardina B
Epilepsia 2011 Feb;52(2):393-400. Epub 2011 Jan 26 doi: 10.1111/j.1528-1167.2010.02926.x. PMID: 21269284

Diagnosis

Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
El Atrache R, Tamilia E, Amengual-Gual M, Mohammadpour Touserkani F, Yang Y, Wang X, Ufongene C, Sheehan T, Cantley S, Jackson M, Zhang B, Papadelis C, Sarkis RA, Loddenkemper T
Epilepsy Behav 2021 Sep;122:108228. Epub 2021 Aug 10 doi: 10.1016/j.yebeh.2021.108228. PMID: 34388667
A long-term, clinical study on symptomatic infantile spasms with focal features.
Fujii A, Oguni H, Hirano Y, Shioda M, Osawa M
Brain Dev 2013 May;35(5):379-85. Epub 2012 Aug 11 doi: 10.1016/j.braindev.2012.06.008. PMID: 22889572
Neonatal stroke and progressive leukoencephalopathy in a child with an ACTA2 mutation.
Moosa AN, Traboulsi EI, Reid J, Prieto L, Moran R, Friedman NR
J Child Neurol 2013 Apr;28(4):531-4. Epub 2012 Jun 29 doi: 10.1177/0883073812446631. PMID: 22752479
Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations.
Naasan G, Yabroudi M, Rahi A, Mikati MA
Epileptic Disord 2009 Dec;11(4):293-300. Epub 2009 Dec 23 doi: 10.1684/epd.2009.0280. PMID: 20031502
Encephalocraniocutaneous lipomatosis.
Moog U
J Med Genet 2009 Nov;46(11):721-9. Epub 2009 Jul 1 doi: 10.1136/jmg.2009.066068. PMID: 19574261

Therapy

Rapid and safe response to low-dose carbamazepine in neonatal epilepsy.
Sands TT, Balestri M, Bellini G, Mulkey SB, Danhaive O, Bakken EH, Taglialatela M, Oldham MS, Vigevano F, Holmes GL, Cilio MR
Epilepsia 2016 Dec;57(12):2019-2030. Epub 2016 Nov 26 doi: 10.1111/epi.13596. PMID: 27888506
Video/EEG findings in a KCNQ2 epileptic encephalopathy: a case report and revision of literature data.
Serino D, Specchio N, Pontrelli G, Vigevano F, Fusco L
Epileptic Disord 2013 Jun;15(2):158-65. doi: 10.1684/epd.2013.0578. PMID: 23774309
A long-term, clinical study on symptomatic infantile spasms with focal features.
Fujii A, Oguni H, Hirano Y, Shioda M, Osawa M
Brain Dev 2013 May;35(5):379-85. Epub 2012 Aug 11 doi: 10.1016/j.braindev.2012.06.008. PMID: 22889572
Absence seizures in the first 3 years of life: an electroclinical study of 46 cases.
Caraballo RH, Darra F, Fontana E, Garcia R, Monese E, Dalla Bernardina B
Epilepsia 2011 Feb;52(2):393-400. Epub 2011 Jan 26 doi: 10.1111/j.1528-1167.2010.02926.x. PMID: 21269284
The development of epilepsy in the paediatric brain.
Velísková J, Velísek L, Sperber EF, Haas KZ, Moshé SL
Seizure 1994 Dec;3(4):263-70. doi: 10.1016/s1059-1311(05)80173-6. PMID: 7894836

Prognosis

Rapid and safe response to low-dose carbamazepine in neonatal epilepsy.
Sands TT, Balestri M, Bellini G, Mulkey SB, Danhaive O, Bakken EH, Taglialatela M, Oldham MS, Vigevano F, Holmes GL, Cilio MR
Epilepsia 2016 Dec;57(12):2019-2030. Epub 2016 Nov 26 doi: 10.1111/epi.13596. PMID: 27888506
A long-term, clinical study on symptomatic infantile spasms with focal features.
Fujii A, Oguni H, Hirano Y, Shioda M, Osawa M
Brain Dev 2013 May;35(5):379-85. Epub 2012 Aug 11 doi: 10.1016/j.braindev.2012.06.008. PMID: 22889572
Absence seizures in the first 3 years of life: an electroclinical study of 46 cases.
Caraballo RH, Darra F, Fontana E, Garcia R, Monese E, Dalla Bernardina B
Epilepsia 2011 Feb;52(2):393-400. Epub 2011 Jan 26 doi: 10.1111/j.1528-1167.2010.02926.x. PMID: 21269284
Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations.
Naasan G, Yabroudi M, Rahi A, Mikati MA
Epileptic Disord 2009 Dec;11(4):293-300. Epub 2009 Dec 23 doi: 10.1684/epd.2009.0280. PMID: 20031502
Crossed cerebellar atrophy in children: a neurologic sequela of extreme prematurity.
Rollins NK, Wen TS, Dominguez R
Pediatr Radiol 1995 Nov;25 Suppl 1:S20-5. PMID: 8577528

Clinical prediction guides

Functional neuropathology of neonatal hypoxia-ischemia by single-mouse longitudinal electroencephalography.
Johnson KJ, Moy B, Rensing N, Robinson A, Ly M, Chengalvala R, Wong M, Galindo R
Epilepsia 2022 Dec;63(12):3037-3050. Epub 2022 Oct 12 doi: 10.1111/epi.17403. PMID: 36054439Free PMC Article
Age-dependent semiology of frontal lobe seizures.
Hintz M, Krenz V, Schulze-Bonhage A
Epilepsy Res 2019 Jan;149:83-87. Epub 2018 Oct 23 doi: 10.1016/j.eplepsyres.2018.10.007. PMID: 30529718
Somatosensory evoked potentials are of additional prognostic value in certain patterns of brain injury in term birth asphyxia.
Swarte RM, Cherian PJ, Lequin M, Visser GH, Govaert P
Clin Neurophysiol 2012 Aug;123(8):1631-8. Epub 2012 Jan 20 doi: 10.1016/j.clinph.2011.12.009. PMID: 22264394
Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations.
Naasan G, Yabroudi M, Rahi A, Mikati MA
Epileptic Disord 2009 Dec;11(4):293-300. Epub 2009 Dec 23 doi: 10.1684/epd.2009.0280. PMID: 20031502
Electroclinical signs of benign neonatal familial convulsions.
Hirsch E, Velez A, Sellal F, Maton B, Grinspan A, Malafosse A, Marescaux C
Ann Neurol 1993 Dec;34(6):835-41. doi: 10.1002/ana.410340613. PMID: 8250533

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