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Skin Squamous Cell Carcinoma with Osteoclast-Like Giant Cells

MedGen UID:
1711087
•Concept ID:
C5237207
•
Neoplastic Process

Definition

A rare squamous cell carcinoma of the skin characterized by the presence of multinucleated non-neoplastic giant cells that resemble osteoclasts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Squamous Cell Carcinoma with Osteoclast-Like Giant Cells

Recent clinical studies

Etiology

Squamous cell carcinoma with osteoclast-like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes.
Chung HJ, Wolpowitz D, Scott G, Gilmore E, Bhawan J
J Cutan Pathol 2016 Feb;43(2):148-57. Epub 2015 Sep 9 doi: 10.1111/cup.12607. PMID: 26272477
Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases.
Beer TW, Drury P, Heenan PJ
Am J Dermatopathol 2010 Aug;32(6):533-40. doi: 10.1097/DAD.0b013e3181c80b97. PMID: 20526171

Diagnosis

Cutaneous Atypical Fibroxanthoma With Osteoclast-Like Giant Cell: A Rare but Diagnostic Pitfall.
Shaker N, Phelps R, Niedt G, Patel A, Wu D, Aung PP, Prieto V, Church A, Pradhan D
Am J Dermatopathol 2023 Oct 1;45(10):704-707. doi: 10.1097/DAD.0000000000002508. PMID: 37708369
Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases.
Beer TW, Drury P, Heenan PJ
Am J Dermatopathol 2010 Aug;32(6):533-40. doi: 10.1097/DAD.0b013e3181c80b97. PMID: 20526171
Poorly differentiated squamous cell carcinoma with osteoclastic giant-cell-like proliferation.
Emanuel PO, Shim H, Phelps RG
J Cutan Pathol 2007 Dec;34(12):930-3. doi: 10.1111/j.1600-0560.2007.00748.x. PMID: 18001416
Pure squamous cell carcinoma of the breast.
Peison B, Benisch B, Chung-Loy H
N J Med 1991 Apr;88(4):273-5. PMID: 2038438

Therapy

Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells in a renal-pancreas transplant recipient.
Aljerian K, Alsaad KO, Chetty R, Ghazarian D
J Clin Pathol 2006 Dec;59(12):1309-11. doi: 10.1136/jcp.2005.034991. PMID: 17142573Free PMC Article

Prognosis

Cutaneous Atypical Fibroxanthoma With Osteoclast-Like Giant Cell: A Rare but Diagnostic Pitfall.
Shaker N, Phelps R, Niedt G, Patel A, Wu D, Aung PP, Prieto V, Church A, Pradhan D
Am J Dermatopathol 2023 Oct 1;45(10):704-707. doi: 10.1097/DAD.0000000000002508. PMID: 37708369
Squamous cell carcinoma with rhabdoid phenotype and osteoclast-like giant cells in a renal-pancreas transplant recipient.
Aljerian K, Alsaad KO, Chetty R, Ghazarian D
J Clin Pathol 2006 Dec;59(12):1309-11. doi: 10.1136/jcp.2005.034991. PMID: 17142573Free PMC Article

Clinical prediction guides

Squamous cell carcinoma with osteoclast-like giant cells: a morphologically heterologous group including carcinosarcoma and squamous cell carcinoma with stromal changes.
Chung HJ, Wolpowitz D, Scott G, Gilmore E, Bhawan J
J Cutan Pathol 2016 Feb;43(2):148-57. Epub 2015 Sep 9 doi: 10.1111/cup.12607. PMID: 26272477
Osteoclast-like giant cell reaction associated with cutaneous squamous cell carcinoma: a report of 2 cases and review of the literature.
Wooff J, Werner D, Murphy J, Walsh N
Am J Dermatopathol 2009 May;31(3):282-7. doi: 10.1097/DAD.0b013e31819cf6f4. PMID: 19384071

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