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Avoidance of stimuli associated with traumatic event

MedGen UID:
1713114
•Concept ID:
C5397944
•
Finding
HPO: HP:0032942

Definition

Avoidance of or efforts to avoid distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s). Avoidance of or efforts to avoid external reminders (people, places, conversations, activities, objects, situations) that arouse distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAvoidance of stimuli associated with traumatic event

Professional guidelines

PubMed

Post-traumatic stress disorder (PTSD) treatment experience in Bedford East - audit and reaudit.
Middleton E, Agius M, Zaman R
Psychiatr Danub 2011 Sep;23 Suppl 1:S104-9. PMID: 21894114
WCA Recommendations for the long-term treatment of posttraumatic stress disorder.
Stein DJ, Bandelow B, Hollander E, Nutt DJ, Okasha A, Pollack MH, Swinson RP, Zohar J; World Council of Anxiety
CNS Spectr 2003 Aug;8(8 Suppl 1):31-9. doi: 10.1017/s1092852900006921. PMID: 14767396

Recent clinical studies

Etiology

Acute Posttrauma Resting-State Functional Connectivity of Periaqueductal Gray Prospectively Predicts Posttraumatic Stress Disorder Symptoms.
Webb EK, Huggins AA, Belleau EL, Taubitz LE, Hanson JL, deRoon-Cassini TA, Larson CL
Biol Psychiatry Cogn Neurosci Neuroimaging 2020 Sep;5(9):891-900. Epub 2020 Mar 28 doi: 10.1016/j.bpsc.2020.03.004. PMID: 32389746Free PMC Article
Emotional conflict adaptation predicts intrusive memories.
Grueschow M, Jelezarova I, Westphal M, Ehlert U, Kleim B
PLoS One 2020;15(2):e0225573. Epub 2020 Feb 20 doi: 10.1371/journal.pone.0225573. PMID: 32078627Free PMC Article
Increased generalization of learned associations is related to re-experiencing symptoms in veterans with symptoms of post-traumatic stress.
Anastasides N, Beck KD, Pang KC, Servatius RJ, Gilbertson MW, Orr SP, Myers CE
Stress 2015;18(4):484-9. Epub 2015 Sep 15 doi: 10.3109/10253890.2015.1053450. PMID: 26372003Free PMC Article
Post-traumatic Stress Disorder in children and adolescents: from Sigmund Freud's "trauma" to psychopathology and the (Dys)metabolic syndrome.
Pervanidou P, Chrousos GP
Horm Metab Res 2007 Jun;39(6):413-9. doi: 10.1055/s-2007-981461. PMID: 17578757
Victims of violence and post-traumatic stress disorder.
Sonnenberg SM
Psychiatr Clin North Am 1988 Dec;11(4):581-90. PMID: 3062592

Diagnosis

Posttraumatic stress symptom dimensions and brain responses to startling auditory stimuli in combat veterans.
Marquardt CA, Pokorny VJ, Kang SS, Cuthbert BN, Sponheim SR
J Abnorm Psychol 2021 Jul;130(5):455-467. doi: 10.1037/abn0000552. PMID: 34472883
Mental health response to acute stress following wilderness disaster.
Mortimer AR
Wilderness Environ Med 2010 Dec;21(4):337-44. Epub 2010 Jun 25 doi: 10.1016/j.wem.2010.06.011. PMID: 21168787
Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder.
Grillon C, Pine DS, Lissek S, Rabin S, Bonne O, Vythilingam M
Biol Psychiatry 2009 Jul 1;66(1):47-53. Epub 2009 Feb 12 doi: 10.1016/j.biopsych.2008.12.028. PMID: 19217076Free PMC Article
WCA Recommendations for the long-term treatment of posttraumatic stress disorder.
Stein DJ, Bandelow B, Hollander E, Nutt DJ, Okasha A, Pollack MH, Swinson RP, Zohar J; World Council of Anxiety
CNS Spectr 2003 Aug;8(8 Suppl 1):31-9. doi: 10.1017/s1092852900006921. PMID: 14767396
Relationship between sense of coherence and post-traumatic stress disorder symptoms among firefighters.
Dudek B, Koniarek J
Int J Occup Med Environ Health 2000;13(4):299-305. PMID: 11276843

Therapy

Post-traumatic stress disorder (PTSD) treatment experience in Bedford East - audit and reaudit.
Middleton E, Agius M, Zaman R
Psychiatr Danub 2011 Sep;23 Suppl 1:S104-9. PMID: 21894114
Mental health response to acute stress following wilderness disaster.
Mortimer AR
Wilderness Environ Med 2010 Dec;21(4):337-44. Epub 2010 Jun 25 doi: 10.1016/j.wem.2010.06.011. PMID: 21168787
Diagnosis and treatment of PTSD-related compulsive checking behaviors in veterans of the Iraq war: the influence of military context on the expression of PTSD symptoms.
Tuerk PW, Grubaugh AL, Hamner MB, Foa EB
Am J Psychiatry 2009 Jul;166(7):762-7. doi: 10.1176/appi.ajp.2009.08091315. PMID: 19570938
Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder.
Grillon C, Pine DS, Lissek S, Rabin S, Bonne O, Vythilingam M
Biol Psychiatry 2009 Jul 1;66(1):47-53. Epub 2009 Feb 12 doi: 10.1016/j.biopsych.2008.12.028. PMID: 19217076Free PMC Article
WCA Recommendations for the long-term treatment of posttraumatic stress disorder.
Stein DJ, Bandelow B, Hollander E, Nutt DJ, Okasha A, Pollack MH, Swinson RP, Zohar J; World Council of Anxiety
CNS Spectr 2003 Aug;8(8 Suppl 1):31-9. doi: 10.1017/s1092852900006921. PMID: 14767396

Prognosis

Acute Posttrauma Resting-State Functional Connectivity of Periaqueductal Gray Prospectively Predicts Posttraumatic Stress Disorder Symptoms.
Webb EK, Huggins AA, Belleau EL, Taubitz LE, Hanson JL, deRoon-Cassini TA, Larson CL
Biol Psychiatry Cogn Neurosci Neuroimaging 2020 Sep;5(9):891-900. Epub 2020 Mar 28 doi: 10.1016/j.bpsc.2020.03.004. PMID: 32389746Free PMC Article
Emotional conflict adaptation predicts intrusive memories.
Grueschow M, Jelezarova I, Westphal M, Ehlert U, Kleim B
PLoS One 2020;15(2):e0225573. Epub 2020 Feb 20 doi: 10.1371/journal.pone.0225573. PMID: 32078627Free PMC Article
Increased generalization of learned associations is related to re-experiencing symptoms in veterans with symptoms of post-traumatic stress.
Anastasides N, Beck KD, Pang KC, Servatius RJ, Gilbertson MW, Orr SP, Myers CE
Stress 2015;18(4):484-9. Epub 2015 Sep 15 doi: 10.3109/10253890.2015.1053450. PMID: 26372003Free PMC Article
Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder.
Grillon C, Pine DS, Lissek S, Rabin S, Bonne O, Vythilingam M
Biol Psychiatry 2009 Jul 1;66(1):47-53. Epub 2009 Feb 12 doi: 10.1016/j.biopsych.2008.12.028. PMID: 19217076Free PMC Article
Post-traumatic Stress Disorder in children and adolescents: from Sigmund Freud's "trauma" to psychopathology and the (Dys)metabolic syndrome.
Pervanidou P, Chrousos GP
Horm Metab Res 2007 Jun;39(6):413-9. doi: 10.1055/s-2007-981461. PMID: 17578757

Clinical prediction guides

Acute Posttrauma Resting-State Functional Connectivity of Periaqueductal Gray Prospectively Predicts Posttraumatic Stress Disorder Symptoms.
Webb EK, Huggins AA, Belleau EL, Taubitz LE, Hanson JL, deRoon-Cassini TA, Larson CL
Biol Psychiatry Cogn Neurosci Neuroimaging 2020 Sep;5(9):891-900. Epub 2020 Mar 28 doi: 10.1016/j.bpsc.2020.03.004. PMID: 32389746Free PMC Article
Emotional conflict adaptation predicts intrusive memories.
Grueschow M, Jelezarova I, Westphal M, Ehlert U, Kleim B
PLoS One 2020;15(2):e0225573. Epub 2020 Feb 20 doi: 10.1371/journal.pone.0225573. PMID: 32078627Free PMC Article
Increased generalization of learned associations is related to re-experiencing symptoms in veterans with symptoms of post-traumatic stress.
Anastasides N, Beck KD, Pang KC, Servatius RJ, Gilbertson MW, Orr SP, Myers CE
Stress 2015;18(4):484-9. Epub 2015 Sep 15 doi: 10.3109/10253890.2015.1053450. PMID: 26372003Free PMC Article
Mental health response to acute stress following wilderness disaster.
Mortimer AR
Wilderness Environ Med 2010 Dec;21(4):337-44. Epub 2010 Jun 25 doi: 10.1016/j.wem.2010.06.011. PMID: 21168787
Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder.
Grillon C, Pine DS, Lissek S, Rabin S, Bonne O, Vythilingam M
Biol Psychiatry 2009 Jul 1;66(1):47-53. Epub 2009 Feb 12 doi: 10.1016/j.biopsych.2008.12.028. PMID: 19217076Free PMC Article

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