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Unresectable Acral Lentiginous Melanoma

MedGen UID:
1713937
•Concept ID:
C5237248
•
Neoplastic Process
Synonym: Unresectable Acral Melanoma

Definition

Acral lentiginous melanoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Acral Lentiginous Melanoma

Recent clinical studies

Etiology

Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study).
Yamazaki N, Takenouchi T, Nakamura Y, Takahashi A, Namikawa K, Kitano S, Fujita T, Kubota K, Yamanaka T, Kawakami Y
Jpn J Clin Oncol 2021 Aug 1;51(8):1232-1241. doi: 10.1093/jjco/hyab064. PMID: 34115870Free PMC Article
Real-world safety and efficacy data of ipilimumab in Japanese radically unresectable malignant melanoma patients: A postmarketing surveillance.
Yamazaki N, Kiyohara Y, Uhara H, Tsuchida T, Maruyama K, Shakunaga N, Itakura E, Komoto A
J Dermatol 2020 Aug;47(8):834-848. Epub 2020 Jun 8 doi: 10.1111/1346-8138.15388. PMID: 32515086Free PMC Article
Development of brain metastases in patients with metastatic melanoma while receiving ipilimumab.
Frenard C, Peuvrel L, Jean MS, Brocard A, Knol AC, Nguyen JM, Khammari A, Quereux G, Dreno B
J Neurooncol 2016 Jan;126(2):355-60. Epub 2015 Oct 28 doi: 10.1007/s11060-015-1977-9. PMID: 26511495
Efficacy and safety of bio-chemotherapy with dacarbazine plus interleukin-2 in patients with unresectable malignant melanoma.
Wu CF, Wang HM, Huang WK, Chang JW
Asia Pac J Clin Oncol 2015 Dec;11(4):314-8. Epub 2015 Aug 26 doi: 10.1111/ajco.12404. PMID: 26310907

Diagnosis

Development of brain metastases in patients with metastatic melanoma while receiving ipilimumab.
Frenard C, Peuvrel L, Jean MS, Brocard A, Knol AC, Nguyen JM, Khammari A, Quereux G, Dreno B
J Neurooncol 2016 Jan;126(2):355-60. Epub 2015 Oct 28 doi: 10.1007/s11060-015-1977-9. PMID: 26511495

Therapy

c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma: a systematic review and one-arm meta-analysis.
Steeb T, Wessely A, Petzold A, Kohl C, Erdmann M, Berking C, Heppt MV
Eur J Cancer 2021 Nov;157:348-357. Epub 2021 Sep 22 doi: 10.1016/j.ejca.2021.08.015. PMID: 34562816
Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study).
Yamazaki N, Takenouchi T, Nakamura Y, Takahashi A, Namikawa K, Kitano S, Fujita T, Kubota K, Yamanaka T, Kawakami Y
Jpn J Clin Oncol 2021 Aug 1;51(8):1232-1241. doi: 10.1093/jjco/hyab064. PMID: 34115870Free PMC Article
Five-year survival with nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma.
Uhara H, Kiyohara Y, Uehara J, Fujisawa Y, Takenouchi T, Otsuka M, Uchi H, Fukushima S, Minami H, Hatsumichi M, Yamazaki N
J Dermatol 2021 May;48(5):592-599. Epub 2021 Mar 14 doi: 10.1111/1346-8138.15804. PMID: 33715172Free PMC Article
Real-world safety and efficacy data of ipilimumab in Japanese radically unresectable malignant melanoma patients: A postmarketing surveillance.
Yamazaki N, Kiyohara Y, Uhara H, Tsuchida T, Maruyama K, Shakunaga N, Itakura E, Komoto A
J Dermatol 2020 Aug;47(8):834-848. Epub 2020 Jun 8 doi: 10.1111/1346-8138.15388. PMID: 32515086Free PMC Article
A phase 2 trial of dasatinib in advanced melanoma.
Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu LB, Molinaro A, Sznol M
Cancer 2011 May 15;117(10):2202-8. Epub 2010 Nov 29 doi: 10.1002/cncr.25766. PMID: 21523734Free PMC Article

Prognosis

Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study).
Yamazaki N, Takenouchi T, Nakamura Y, Takahashi A, Namikawa K, Kitano S, Fujita T, Kubota K, Yamanaka T, Kawakami Y
Jpn J Clin Oncol 2021 Aug 1;51(8):1232-1241. doi: 10.1093/jjco/hyab064. PMID: 34115870Free PMC Article
Real-world safety and efficacy data of ipilimumab in Japanese radically unresectable malignant melanoma patients: A postmarketing surveillance.
Yamazaki N, Kiyohara Y, Uhara H, Tsuchida T, Maruyama K, Shakunaga N, Itakura E, Komoto A
J Dermatol 2020 Aug;47(8):834-848. Epub 2020 Jun 8 doi: 10.1111/1346-8138.15388. PMID: 32515086Free PMC Article
Efficacy and safety of bio-chemotherapy with dacarbazine plus interleukin-2 in patients with unresectable malignant melanoma.
Wu CF, Wang HM, Huang WK, Chang JW
Asia Pac J Clin Oncol 2015 Dec;11(4):314-8. Epub 2015 Aug 26 doi: 10.1111/ajco.12404. PMID: 26310907
A phase 2 trial of dasatinib in advanced melanoma.
Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu LB, Molinaro A, Sznol M
Cancer 2011 May 15;117(10):2202-8. Epub 2010 Nov 29 doi: 10.1002/cncr.25766. PMID: 21523734Free PMC Article

Clinical prediction guides

Prospective observational study of the efficacy of nivolumab in Japanese patients with advanced melanoma (CREATIVE study).
Yamazaki N, Takenouchi T, Nakamura Y, Takahashi A, Namikawa K, Kitano S, Fujita T, Kubota K, Yamanaka T, Kawakami Y
Jpn J Clin Oncol 2021 Aug 1;51(8):1232-1241. doi: 10.1093/jjco/hyab064. PMID: 34115870Free PMC Article
Five-year survival with nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma.
Uhara H, Kiyohara Y, Uehara J, Fujisawa Y, Takenouchi T, Otsuka M, Uchi H, Fukushima S, Minami H, Hatsumichi M, Yamazaki N
J Dermatol 2021 May;48(5):592-599. Epub 2021 Mar 14 doi: 10.1111/1346-8138.15804. PMID: 33715172Free PMC Article
Real-world safety and efficacy data of ipilimumab in Japanese radically unresectable malignant melanoma patients: A postmarketing surveillance.
Yamazaki N, Kiyohara Y, Uhara H, Tsuchida T, Maruyama K, Shakunaga N, Itakura E, Komoto A
J Dermatol 2020 Aug;47(8):834-848. Epub 2020 Jun 8 doi: 10.1111/1346-8138.15388. PMID: 32515086Free PMC Article
A phase 2 trial of dasatinib in advanced melanoma.
Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu LB, Molinaro A, Sznol M
Cancer 2011 May 15;117(10):2202-8. Epub 2010 Nov 29 doi: 10.1002/cncr.25766. PMID: 21523734Free PMC Article

Recent systematic reviews

c-Kit inhibitors for unresectable or metastatic mucosal, acral or chronically sun-damaged melanoma: a systematic review and one-arm meta-analysis.
Steeb T, Wessely A, Petzold A, Kohl C, Erdmann M, Berking C, Heppt MV
Eur J Cancer 2021 Nov;157:348-357. Epub 2021 Sep 22 doi: 10.1016/j.ejca.2021.08.015. PMID: 34562816

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