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Focal impaired awareness bilateral motor seizure

MedGen UID:
1713986
•Concept ID:
C5397724
•
Disease or Syndrome
HPO: HP:0032714

Definition

A focal bilateral motor seizure characterized by impairment of awareness at some point during the seizure. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal impaired awareness bilateral motor seizure

Professional guidelines

PubMed

A multivariable prediction model of a major treatment response for focal-onset seizures: A post-hoc analysis of Phase III trials of perampanel.
Krauss GL, Ben-Menachem E, Wechsler RT, Patten A, Williams B, Laurenza A, Malhotra M
Epilepsy Res 2021 Aug;174:106649. Epub 2021 May 12 doi: 10.1016/j.eplepsyres.2021.106649. PMID: 34022524
Hypothalamic hamartomas in adulthood: Clinical spectrum and treatment outcome-A unicenter experience.
Conde Blanco E, Anciones Martín C, Manzanares I, Gil López F, Roldán P, Donaire A, Rumiá J, Carreño M
Brain Behav 2019 Nov;9(11):e01412. Epub 2019 Oct 2 doi: 10.1002/brb3.1412. PMID: 31578831Free PMC Article
Genotype/phenotype of 6 Chinese cases with Niemann-Pick disease type C.
Xiong H, Higaki K, Wei CJ, Bao XH, Zhang YH, Fu N, Qin J, Adachi K, Kumura Y, Ninomiya H, Nanba E, Wu XR
Gene 2012 May 1;498(2):332-5. Epub 2012 Feb 4 doi: 10.1016/j.gene.2012.01.026. PMID: 22326530

Recent clinical studies

Etiology

Sudden unexpected death in epilepsy during cenobamate clinical development.
Rosenfeld WE, Ferrari L, Kerr WT, Sperling MR
Epilepsia 2023 Aug;64(8):2108-2115. Epub 2023 Jun 5 doi: 10.1111/epi.17662. PMID: 37219391
Focal epilepsies: Update on diagnosis and classification.
Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Duration of postictal impaired awareness after bilateral tonic-clonic seizures: EEG and patient characteristics.
Kanth KM, Zimmerman CS, Toprani SC, Seyal M
Epilepsy Behav 2022 Mar;128:108576. Epub 2022 Feb 2 doi: 10.1016/j.yebeh.2022.108576. PMID: 35123240
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103

Diagnosis

Diabetes ketoacidosis and Recurrent Childhood Stroke-like Episodes.
Liu RC, Sheu JN, Liu CS, Tsai JD
Acta Neurol Taiwan 2024 Mar 30;33(1):41-42. PMID: 37853548
Focal epilepsies: Update on diagnosis and classification.
Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903
Conversational analysis of consciousness during seizures.
Uchitel J, McDade C, Mathew M, Mantri S, Jenson D, Husain AM
Epilepsy Behav 2020 Nov;112:107486. Epub 2020 Sep 29 doi: 10.1016/j.yebeh.2020.107486. PMID: 33181894
Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?
Guignet M, Campbell A, White HS
Epilepsia 2020 Nov;61(11):2329-2339. Epub 2020 Oct 16 doi: 10.1111/epi.16718. PMID: 33063849
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article

Therapy

Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention.
Cutillo G, Tolba H, Hirsch LJ
Epilepsy Behav 2021 Apr;117:107815. Epub 2021 Feb 26 doi: 10.1016/j.yebeh.2021.107815. PMID: 33640562
Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?
Guignet M, Campbell A, White HS
Epilepsia 2020 Nov;61(11):2329-2339. Epub 2020 Oct 16 doi: 10.1111/epi.16718. PMID: 33063849
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Prognosis

Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.
Juan E, Górska U, Kozma C, Papantonatos C, Bugnon T, Denis C, Kremen V, Worrell G, Struck AF, Bateman LM, Merricks EM, Blumenfeld H, Tononi G, Schevon C, Boly M
Brain 2023 Jan 5;146(1):109-123. doi: 10.1093/brain/awac291. PMID: 36383415Free PMC Article
Distribution of postictal slowing has an additional yield to interictal epileptiform discharge in predicting surgical outcomes in temporal lobe epilepsy.
Shaaban S, Kakisaka Y, Belal T, Jin K, Osawa SI, Tominaga T, Elmenshawi I, Nakasato N
Epilepsia Open 2022 Dec;7(4):802-809. Epub 2022 Oct 29 doi: 10.1002/epi4.12660. PMID: 36225084Free PMC Article
Cluster analysis: Predicting the seizure outcome in temporal lobe epilepsy.
Asadi-Pooya AA, Farazdaghi M
Epilepsy Behav 2022 Jan;126:108495. Epub 2021 Dec 16 doi: 10.1016/j.yebeh.2021.108495. PMID: 34923259
Epilepsy and EEG Abnormalities in Children with Autism Spectrum Disorders.
Sharma V, Saini AG, Malhi P, Singhi P
Indian J Pediatr 2022 Oct;89(10):975-982. Epub 2021 Nov 29 doi: 10.1007/s12098-021-03928-w. PMID: 34843062
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Clinical prediction guides

Diabetes ketoacidosis and Recurrent Childhood Stroke-like Episodes.
Liu RC, Sheu JN, Liu CS, Tsai JD
Acta Neurol Taiwan 2024 Mar 30;33(1):41-42. PMID: 37853548
Distribution of postictal slowing has an additional yield to interictal epileptiform discharge in predicting surgical outcomes in temporal lobe epilepsy.
Shaaban S, Kakisaka Y, Belal T, Jin K, Osawa SI, Tominaga T, Elmenshawi I, Nakasato N
Epilepsia Open 2022 Dec;7(4):802-809. Epub 2022 Oct 29 doi: 10.1002/epi4.12660. PMID: 36225084Free PMC Article
Cluster analysis: Predicting the seizure outcome in temporal lobe epilepsy.
Asadi-Pooya AA, Farazdaghi M
Epilepsy Behav 2022 Jan;126:108495. Epub 2021 Dec 16 doi: 10.1016/j.yebeh.2021.108495. PMID: 34923259
Focal impaired awareness seizures in a rodent model: A functional anatomy.
Adotevi N, Kapur J
Epilepsia Open 2022 Mar;7(1):110-123. Epub 2021 Dec 17 doi: 10.1002/epi4.12563. PMID: 34822222Free PMC Article
Seizure onset predicts its type.
Donos C, Maliia MD, Dümpelmann M, Schulze-Bonhage A
Epilepsia 2018 Mar;59(3):650-660. Epub 2018 Jan 11 doi: 10.1111/epi.13997. PMID: 29322500

Recent systematic reviews

Dyke-Davidoff-Masson Syndrome: Main clinical and radiological findings- systematic literature review.
Rondão MBA, Hsu BRRHS, Centeno RS, de Aguiar PHP
Seizure 2023 Aug;110:58-68. Epub 2023 Jun 3 doi: 10.1016/j.seizure.2023.04.020. PMID: 37327751
Optimal timing of interictal FDG-PET for epilepsy surgery: A systematic review on time since last seizure.
de Laat NN, Tolboom N, Leijten FSS
Epilepsia Open 2022 Sep;7(3):512-517. Epub 2022 Jun 20 doi: 10.1002/epi4.12617. PMID: 35666076Free PMC Article
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention.
Cutillo G, Tolba H, Hirsch LJ
Epilepsy Behav 2021 Apr;117:107815. Epub 2021 Feb 26 doi: 10.1016/j.yebeh.2021.107815. PMID: 33640562

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