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Peritoneal Sarcomatoid Mesothelioma

MedGen UID:
1714288
•Concept ID:
C5239129
•
Neoplastic Process

Definition

Malignant mesothelioma that arises from the peritoneum. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeritoneal Sarcomatoid Mesothelioma

Professional guidelines

PubMed

Principles of Surgical Management of Peritoneal Mesothelioma.
Steadman JA, Grotz TE
J Natl Compr Canc Netw 2023 Sep;21(9):981-986. doi: 10.6004/jnccn.2023.7055. PMID: 37673112
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR
Arch Pathol Lab Med 2018 Jan;142(1):89-108. Epub 2017 Jul 7 doi: 10.5858/arpa.2017-0124-RA. PMID: 28686500
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Recent clinical studies

Etiology

Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly.
Pan D, Wang M, Liu W, Li Y, Sang L, Chang B
BMC Gastroenterol 2022 Jun 9;22(1):292. doi: 10.1186/s12876-022-02361-3. PMID: 35681152Free PMC Article
Malignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes.
Atre ID, Watane GV, Harisinghani MG
Abdom Radiol (NY) 2021 Nov;46(11):5105-5113. Epub 2021 Aug 3 doi: 10.1007/s00261-021-03231-4. PMID: 34342707
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR
Arch Pathol Lab Med 2018 Jan;142(1):89-108. Epub 2017 Jul 7 doi: 10.5858/arpa.2017-0124-RA. PMID: 28686500
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Peritoneal mesothelioma.
Kannerstein M, Churg J
Hum Pathol 1977 Jan;8(1):83-94. doi: 10.1016/s0046-8177(77)80067-1. PMID: 844856

Diagnosis

Malignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes.
Atre ID, Watane GV, Harisinghani MG
Abdom Radiol (NY) 2021 Nov;46(11):5105-5113. Epub 2021 Aug 3 doi: 10.1007/s00261-021-03231-4. PMID: 34342707
Diagnosis of Mesothelioma.
Fels Elliott DR, Jones KD
Surg Pathol Clin 2020 Mar;13(1):73-89. Epub 2019 Dec 3 doi: 10.1016/j.path.2019.10.001. PMID: 32005436
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR
Arch Pathol Lab Med 2018 Jan;142(1):89-108. Epub 2017 Jul 7 doi: 10.5858/arpa.2017-0124-RA. PMID: 28686500
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896
Peritoneal mesothelioma.
Kannerstein M, Churg J
Hum Pathol 1977 Jan;8(1):83-94. doi: 10.1016/s0046-8177(77)80067-1. PMID: 844856

Therapy

Combined MEK and PI3K/p110β Inhibition as a Novel Targeted Therapy for Malignant Mesothelioma Displaying Sarcomatoid Features.
Marqués M, Tranchant R, Risa-Ebrí B, Suárez-Solís ML, Fernández LC, Carrillo-de-Santa-Pau E, Del Pozo N, Martínez de Villarreal J, Meiller C, Allory Y, Blum Y, Pirker C, Hegedus B, Barry ST, Carnero A, Berger W, Jean D, Real FX
Cancer Res 2020 Feb 15;80(4):843-856. Epub 2020 Jan 7 doi: 10.1158/0008-5472.CAN-19-1633. PMID: 31911549
Malignant Peritoneal Mesothelioma: National Practice Patterns, Outcomes, and Predictors of Survival.
Verma V, Sleightholm RL, Rusthoven CG, Koshy M, Sher DJ, Grover S, Simone CB 2nd
Ann Surg Oncol 2018 Jul;25(7):2018-2026. Epub 2018 May 2 doi: 10.1245/s10434-018-6499-1. PMID: 29721724
Sarcomatoid Peritoneal Mesothelioma: Clinicopathologic Correlation of 13 Cases.
Pavlisko EN, Roggli VL
Am J Surg Pathol 2015 Nov;39(11):1568-75. doi: 10.1097/PAS.0000000000000495. PMID: 26371785
Peritoneal mesothelioma: the site of origin matters.
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Peritoneal mesothelioma.
Kannerstein M, Churg J
Hum Pathol 1977 Jan;8(1):83-94. doi: 10.1016/s0046-8177(77)80067-1. PMID: 844856

Prognosis

Principles of Surgical Management of Peritoneal Mesothelioma.
Steadman JA, Grotz TE
J Natl Compr Canc Netw 2023 Sep;21(9):981-986. doi: 10.6004/jnccn.2023.7055. PMID: 37673112
FDG PET/CT for Staging and Restaging Malignant Mesothelioma.
Lopci E, Castello A, Mansi L
Semin Nucl Med 2022 Nov;52(6):806-815. Epub 2022 Aug 11 doi: 10.1053/j.semnuclmed.2022.07.005. PMID: 35965111
Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly.
Pan D, Wang M, Liu W, Li Y, Sang L, Chang B
BMC Gastroenterol 2022 Jun 9;22(1):292. doi: 10.1186/s12876-022-02361-3. PMID: 35681152Free PMC Article
Malignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes.
Atre ID, Watane GV, Harisinghani MG
Abdom Radiol (NY) 2021 Nov;46(11):5105-5113. Epub 2021 Aug 3 doi: 10.1007/s00261-021-03231-4. PMID: 34342707
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR
Arch Pathol Lab Med 2018 Jan;142(1):89-108. Epub 2017 Jul 7 doi: 10.5858/arpa.2017-0124-RA. PMID: 28686500

Clinical prediction guides

Principles of Surgical Management of Peritoneal Mesothelioma.
Steadman JA, Grotz TE
J Natl Compr Canc Netw 2023 Sep;21(9):981-986. doi: 10.6004/jnccn.2023.7055. PMID: 37673112
Characterizing the distribution of alterations in mesothelioma and their correlation to morphology.
Chen-Yost HI, Tjota MY, Gao G, Mitchell O, Kindler H, Segal J, Husain AN, Mueller J, Schulte JJ
Am J Clin Pathol 2023 Sep 1;160(3):238-246. doi: 10.1093/ajcp/aqad041. PMID: 37141416
Molecular Characterization of Mesothelioma: Impact of Histologic Type and Site of Origin on Molecular Landscape.
Dagogo-Jack I, Madison RW, Lennerz JK, Chen KT, Hopkins JF, Schrock AB, Ritterhouse LL, Lester A, Wharton KA Jr, Mino-Kenudson M, Danziger N, Hung YP, Mata DA, Ross JS
JCO Precis Oncol 2022 Jun;6:e2100422. doi: 10.1200/PO.21.00422. PMID: 35704798
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR
Arch Pathol Lab Med 2018 Jan;142(1):89-108. Epub 2017 Jul 7 doi: 10.5858/arpa.2017-0124-RA. PMID: 28686500
Sarcomatoid Peritoneal Mesothelioma: Clinicopathologic Correlation of 13 Cases.
Pavlisko EN, Roggli VL
Am J Surg Pathol 2015 Nov;39(11):1568-75. doi: 10.1097/PAS.0000000000000495. PMID: 26371785

Recent systematic reviews

The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639

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