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HER2-Negative Breast Carcinoma

MedGen UID:
1714400
•Concept ID:
C5238910
•
Neoplastic Process
Synonyms: HER2 Negative Breast Adenocarcinoma; HER2 Negative Breast Carcinoma

Definition

A breast adenocarcinoma which is negative for the expression of the HER2 receptor. [from NCI]

Professional guidelines

PubMed

Endocrine Treatment and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: ASCO Guideline Update.
Burstein HJ, Somerfield MR, Barton DL, Dorris A, Fallowfield LJ, Jain D, Johnston SRD, Korde LA, Litton JK, Macrae ER, Peterson LL, Vikas P, Yung RL, Rugo HS
J Clin Oncol 2021 Dec 10;39(35):3959-3977. Epub 2021 Jul 29 doi: 10.1200/JCO.21.01392. PMID: 34324367Free PMC Article
An Overview of PARP Inhibitors for the Treatment of Breast Cancer.
Cortesi L, Rugo HS, Jackisch C
Target Oncol 2021 May;16(3):255-282. Epub 2021 Mar 12 doi: 10.1007/s11523-021-00796-4. PMID: 33710534Free PMC Article
Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline.
Korde LA, Somerfield MR, Carey LA, Crews JR, Denduluri N, Hwang ES, Khan SA, Loibl S, Morris EA, Perez A, Regan MM, Spears PA, Sudheendra PK, Symmans WF, Yung RL, Harvey BE, Hershman DL
J Clin Oncol 2021 May 1;39(13):1485-1505. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03399. PMID: 33507815Free PMC Article

Recent clinical studies

Etiology

Prognostic impact of discrepant Ki67 and mitotic index on hormone receptor-positive, HER2-negative breast carcinoma.
Rossi L, Laas E, Mallon P, Vincent-Salomon A, Guinebretiere JM, Lerebours F, Rouzier R, Pierga JY, Reyal F
Br J Cancer 2015 Sep 29;113(7):996-1002. Epub 2015 Sep 17 doi: 10.1038/bjc.2015.239. PMID: 26379080Free PMC Article
Progesterone receptor status in determining the prognosis of estrogen receptor positive/ HER2 negative breast carcinoma patients.
Bal O, Yalcintas Arslan U, Durnali A, Uyetrk U, Demirci A, Tastekin D, Ekinci A, Esbah O, Turker I, Uysal Sonmez O, Oksuzoglu B
J BUON 2015 Jan-Feb;20(1):28-34. PMID: 25778292
Histological grade concordance between diagnostic core biopsy and corresponding surgical specimen in HR-positive/HER2-negative breast carcinoma.
Daveau C, Baulies S, Lalloum M, Bollet M, Sigal-Zafrani B, Sastre X, Vincent-Salomon A, Tardivon A, Thibault F, Pierga JY, Cottu P, Sablin MP, Rouzier R, Malhaire C, Mallon P, Reyal F
Br J Cancer 2014 Apr 29;110(9):2195-200. Epub 2014 Apr 8 doi: 10.1038/bjc.2014.143. PMID: 24714751Free PMC Article
The identification of a small but significant subset of patients still targetable with anti-HER2 inhibitors when affected by triple negative breast carcinoma.
Brunello E, Bogina G, Bria E, Vergine M, Zamboni G, Pedron S, Daniele I, Furlanetto J, Carbognin L, Marconi M, Manfrin E, Ibrahim M, Miller K, Tortora G, Molino A, Jasani B, Beccari S, Bonetti F, Chilosi M, Martignoni G, Brunelli M
J Cancer Res Clin Oncol 2013 Sep;139(9):1563-8. Epub 2013 Jul 28 doi: 10.1007/s00432-013-1479-0. PMID: 23892410
Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization.
Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B, Schnall M, Alavi A
Cancer 2008 Mar 1;112(5):995-1000. doi: 10.1002/cncr.23226. PMID: 18098228

Diagnosis

Breast carcinoma with an Oncotype Dx recurrence score <18: Rate of distant metastases in a large series with clinical follow-up.
Wen HY, Krystel-Whittemore M, Patil S, Pareja F, Bowser ZL, Dickler MN, Norton L, Morrow M, Hudis CA, Brogi E
Cancer 2017 Jan 1;123(1):131-137. Epub 2016 Aug 15 doi: 10.1002/cncr.30271. PMID: 27526056Free PMC Article
Progesterone receptor status in determining the prognosis of estrogen receptor positive/ HER2 negative breast carcinoma patients.
Bal O, Yalcintas Arslan U, Durnali A, Uyetrk U, Demirci A, Tastekin D, Ekinci A, Esbah O, Turker I, Uysal Sonmez O, Oksuzoglu B
J BUON 2015 Jan-Feb;20(1):28-34. PMID: 25778292
Histological grade concordance between diagnostic core biopsy and corresponding surgical specimen in HR-positive/HER2-negative breast carcinoma.
Daveau C, Baulies S, Lalloum M, Bollet M, Sigal-Zafrani B, Sastre X, Vincent-Salomon A, Tardivon A, Thibault F, Pierga JY, Cottu P, Sablin MP, Rouzier R, Malhaire C, Mallon P, Reyal F
Br J Cancer 2014 Apr 29;110(9):2195-200. Epub 2014 Apr 8 doi: 10.1038/bjc.2014.143. PMID: 24714751Free PMC Article
The identification of a small but significant subset of patients still targetable with anti-HER2 inhibitors when affected by triple negative breast carcinoma.
Brunello E, Bogina G, Bria E, Vergine M, Zamboni G, Pedron S, Daniele I, Furlanetto J, Carbognin L, Marconi M, Manfrin E, Ibrahim M, Miller K, Tortora G, Molino A, Jasani B, Beccari S, Bonetti F, Chilosi M, Martignoni G, Brunelli M
J Cancer Res Clin Oncol 2013 Sep;139(9):1563-8. Epub 2013 Jul 28 doi: 10.1007/s00432-013-1479-0. PMID: 23892410
Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization.
Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B, Schnall M, Alavi A
Cancer 2008 Mar 1;112(5):995-1000. doi: 10.1002/cncr.23226. PMID: 18098228

Therapy

Phase 1 trial of ADI-PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors.
Yao S, Janku F, Koenig K, Tsimberidou AM, Piha-Paul SA, Shi N, Stewart J, Johnston A, Bomalaski J, Meric-Bernstam F, Fu S
Cancer Med 2022 Jan;11(2):340-347. Epub 2021 Nov 28 doi: 10.1002/cam4.4446. PMID: 34841717Free PMC Article
Utility of Human Epidermal Growth Factor Receptor 2 (HER2) Retesting of Histologic Grade 3 Invasive Breast Carcinomas.
Gologorsky R, Cureton E, Shim V
Perm J 2019;23:18-088. doi: 10.7812/TPP/18-088. PMID: 30624197Free PMC Article
Breast carcinoma with an Oncotype Dx recurrence score <18: Rate of distant metastases in a large series with clinical follow-up.
Wen HY, Krystel-Whittemore M, Patil S, Pareja F, Bowser ZL, Dickler MN, Norton L, Morrow M, Hudis CA, Brogi E
Cancer 2017 Jan 1;123(1):131-137. Epub 2016 Aug 15 doi: 10.1002/cncr.30271. PMID: 27526056Free PMC Article
The identification of a small but significant subset of patients still targetable with anti-HER2 inhibitors when affected by triple negative breast carcinoma.
Brunello E, Bogina G, Bria E, Vergine M, Zamboni G, Pedron S, Daniele I, Furlanetto J, Carbognin L, Marconi M, Manfrin E, Ibrahim M, Miller K, Tortora G, Molino A, Jasani B, Beccari S, Bonetti F, Chilosi M, Martignoni G, Brunelli M
J Cancer Res Clin Oncol 2013 Sep;139(9):1563-8. Epub 2013 Jul 28 doi: 10.1007/s00432-013-1479-0. PMID: 23892410
Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization.
Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B, Schnall M, Alavi A
Cancer 2008 Mar 1;112(5):995-1000. doi: 10.1002/cncr.23226. PMID: 18098228

Prognosis

Phase 1 trial of ADI-PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors.
Yao S, Janku F, Koenig K, Tsimberidou AM, Piha-Paul SA, Shi N, Stewart J, Johnston A, Bomalaski J, Meric-Bernstam F, Fu S
Cancer Med 2022 Jan;11(2):340-347. Epub 2021 Nov 28 doi: 10.1002/cam4.4446. PMID: 34841717Free PMC Article
Prognostic impact of discrepant Ki67 and mitotic index on hormone receptor-positive, HER2-negative breast carcinoma.
Rossi L, Laas E, Mallon P, Vincent-Salomon A, Guinebretiere JM, Lerebours F, Rouzier R, Pierga JY, Reyal F
Br J Cancer 2015 Sep 29;113(7):996-1002. Epub 2015 Sep 17 doi: 10.1038/bjc.2015.239. PMID: 26379080Free PMC Article
Progesterone receptor status in determining the prognosis of estrogen receptor positive/ HER2 negative breast carcinoma patients.
Bal O, Yalcintas Arslan U, Durnali A, Uyetrk U, Demirci A, Tastekin D, Ekinci A, Esbah O, Turker I, Uysal Sonmez O, Oksuzoglu B
J BUON 2015 Jan-Feb;20(1):28-34. PMID: 25778292
Histological grade concordance between diagnostic core biopsy and corresponding surgical specimen in HR-positive/HER2-negative breast carcinoma.
Daveau C, Baulies S, Lalloum M, Bollet M, Sigal-Zafrani B, Sastre X, Vincent-Salomon A, Tardivon A, Thibault F, Pierga JY, Cottu P, Sablin MP, Rouzier R, Malhaire C, Mallon P, Reyal F
Br J Cancer 2014 Apr 29;110(9):2195-200. Epub 2014 Apr 8 doi: 10.1038/bjc.2014.143. PMID: 24714751Free PMC Article
The identification of a small but significant subset of patients still targetable with anti-HER2 inhibitors when affected by triple negative breast carcinoma.
Brunello E, Bogina G, Bria E, Vergine M, Zamboni G, Pedron S, Daniele I, Furlanetto J, Carbognin L, Marconi M, Manfrin E, Ibrahim M, Miller K, Tortora G, Molino A, Jasani B, Beccari S, Bonetti F, Chilosi M, Martignoni G, Brunelli M
J Cancer Res Clin Oncol 2013 Sep;139(9):1563-8. Epub 2013 Jul 28 doi: 10.1007/s00432-013-1479-0. PMID: 23892410

Clinical prediction guides

Phase 1 trial of ADI-PEG 20 and liposomal doxorubicin in patients with metastatic solid tumors.
Yao S, Janku F, Koenig K, Tsimberidou AM, Piha-Paul SA, Shi N, Stewart J, Johnston A, Bomalaski J, Meric-Bernstam F, Fu S
Cancer Med 2022 Jan;11(2):340-347. Epub 2021 Nov 28 doi: 10.1002/cam4.4446. PMID: 34841717Free PMC Article
Breast carcinoma with an Oncotype Dx recurrence score <18: Rate of distant metastases in a large series with clinical follow-up.
Wen HY, Krystel-Whittemore M, Patil S, Pareja F, Bowser ZL, Dickler MN, Norton L, Morrow M, Hudis CA, Brogi E
Cancer 2017 Jan 1;123(1):131-137. Epub 2016 Aug 15 doi: 10.1002/cncr.30271. PMID: 27526056Free PMC Article
Progesterone receptor status in determining the prognosis of estrogen receptor positive/ HER2 negative breast carcinoma patients.
Bal O, Yalcintas Arslan U, Durnali A, Uyetrk U, Demirci A, Tastekin D, Ekinci A, Esbah O, Turker I, Uysal Sonmez O, Oksuzoglu B
J BUON 2015 Jan-Feb;20(1):28-34. PMID: 25778292
Histological grade concordance between diagnostic core biopsy and corresponding surgical specimen in HR-positive/HER2-negative breast carcinoma.
Daveau C, Baulies S, Lalloum M, Bollet M, Sigal-Zafrani B, Sastre X, Vincent-Salomon A, Tardivon A, Thibault F, Pierga JY, Cottu P, Sablin MP, Rouzier R, Malhaire C, Mallon P, Reyal F
Br J Cancer 2014 Apr 29;110(9):2195-200. Epub 2014 Apr 8 doi: 10.1038/bjc.2014.143. PMID: 24714751Free PMC Article
Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization.
Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B, Schnall M, Alavi A
Cancer 2008 Mar 1;112(5):995-1000. doi: 10.1002/cncr.23226. PMID: 18098228

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