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Abnormal chondrocyte morphology

MedGen UID:: 1714402
•Concept ID:: C5397934
•: Cell or Molecular Dysfunction

HPO:	HP:0032929

Definition

Any abnormal structure of a chondrocyte, which is a polymorphic cell that forms cartilage. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal chondrocyte morphology

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the skeletal system
    - Abnormal skeletal morphology
      - Abnormal cartilage morphology
        Abnormal chondrocyte morphology
        Lacunar halos around chondrocytes
        Multinucleated giant chondrocytes in epiphyseal cartilage

Professional guidelines

PubMed

Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis.

Hodgkinson T, Kelly DC, Curtin CM, O'Brien FJ
Nat Rev Rheumatol 2022 Feb;18(2):67-84. Epub 2021 Dec 21 doi: 10.1038/s41584-021-00724-w. PMID: 34934171

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis.

Hu W, Chen Y, Dou C, Dong S
Ann Rheum Dis 2021 Apr;80(4):413-422. Epub 2020 Nov 6 doi: 10.1136/annrheumdis-2020-218089. PMID: 33158879 Free PMC Article

Management of Articular Cartilage Defects in the Glenohumeral Joint.

Seidl AJ, Kraeutler MJ
J Am Acad Orthop Surg 2018 Jun 1;26(11):e230-e237. doi: 10.5435/JAAOS-D-17-00057. PMID: 29697499

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