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Neonatal bilateral symmetric tonic seizure

MedGen UID:
1714641
•Concept ID:
C5397834
•
Disease or Syndrome
HPO: HP:0032828

Definition

Neonatal bilateral symmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body symmetrically. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal bilateral symmetric tonic seizure

Recent clinical studies

Etiology

Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
El Atrache R, Tamilia E, Amengual-Gual M, Mohammadpour Touserkani F, Yang Y, Wang X, Ufongene C, Sheehan T, Cantley S, Jackson M, Zhang B, Papadelis C, Sarkis RA, Loddenkemper T
Epilepsy Behav 2021 Sep;122:108228. Epub 2021 Aug 10 doi: 10.1016/j.yebeh.2021.108228. PMID: 34388667
Early-onset bilateral cerebral arteriopathies: Cohort study of phenotype and disease course.
Al-Yassin A, Saunders DE, Mackay MT, Ganesan V
Neurology 2015 Sep 29;85(13):1146-53. Epub 2015 Aug 28 doi: 10.1212/WNL.0000000000001969. PMID: 26320201
Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.
Mercimek-Mahmutoglu S, Horvath GA, Coulter-Mackie M, Nelson T, Waters PJ, Sargent M, Struys E, Jakobs C, Stockler-Ipsiroglu S, Connolly MB
Pediatrics 2012 May;129(5):e1368-72. Epub 2012 Apr 23 doi: 10.1542/peds.2011-0123. PMID: 22529283
Absence seizures in the first 3 years of life: an electroclinical study of 46 cases.
Caraballo RH, Darra F, Fontana E, Garcia R, Monese E, Dalla Bernardina B
Epilepsia 2011 Feb;52(2):393-400. Epub 2011 Jan 26 doi: 10.1111/j.1528-1167.2010.02926.x. PMID: 21269284
Benign neonatal sleep myoclonus: experience from the study of 38 infants.
Paro-Panjan D, Neubauer D
Eur J Paediatr Neurol 2008 Jan;12(1):14-8. Epub 2007 Jun 18 doi: 10.1016/j.ejpn.2007.05.002. PMID: 17574462

Diagnosis

Novel compound heterozygous variants in the PCCB gene causing adult-onset propionic acidemia presenting with neuropsychiatric symptoms: a case report and literature review.
Li Y, Wang M, Huang Z, Ye J, Wang Y
BMC Med Genomics 2022 Mar 16;15(1):59. doi: 10.1186/s12920-022-01202-2. PMID: 35296328Free PMC Article
Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.
El Atrache R, Tamilia E, Amengual-Gual M, Mohammadpour Touserkani F, Yang Y, Wang X, Ufongene C, Sheehan T, Cantley S, Jackson M, Zhang B, Papadelis C, Sarkis RA, Loddenkemper T
Epilepsy Behav 2021 Sep;122:108228. Epub 2021 Aug 10 doi: 10.1016/j.yebeh.2021.108228. PMID: 34388667
Early-onset bilateral cerebral arteriopathies: Cohort study of phenotype and disease course.
Al-Yassin A, Saunders DE, Mackay MT, Ganesan V
Neurology 2015 Sep 29;85(13):1146-53. Epub 2015 Aug 28 doi: 10.1212/WNL.0000000000001969. PMID: 26320201
Bilateral perisylvian ulegyria: an under-recognized, surgically remediable epileptic syndrome.
Schilling LP, Kieling RR, Pascoal TA, Kim HI, Lee MC, Kim YH, Paglioli E, Neto PR, Costa JC, Palmini A
Epilepsia 2013 Aug;54(8):1360-7. Epub 2013 Apr 15 doi: 10.1111/epi.12160. PMID: 23586600
Lennox-Gastaut syndrome (childhood epileptic encephalopathy).
Markand ON
J Clin Neurophysiol 2003 Nov-Dec;20(6):426-41. doi: 10.1097/00004691-200311000-00005. PMID: 14734932

Therapy

Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.
Mercimek-Mahmutoglu S, Horvath GA, Coulter-Mackie M, Nelson T, Waters PJ, Sargent M, Struys E, Jakobs C, Stockler-Ipsiroglu S, Connolly MB
Pediatrics 2012 May;129(5):e1368-72. Epub 2012 Apr 23 doi: 10.1542/peds.2011-0123. PMID: 22529283
Absence seizures in the first 3 years of life: an electroclinical study of 46 cases.
Caraballo RH, Darra F, Fontana E, Garcia R, Monese E, Dalla Bernardina B
Epilepsia 2011 Feb;52(2):393-400. Epub 2011 Jan 26 doi: 10.1111/j.1528-1167.2010.02926.x. PMID: 21269284
Therapy resistant neonatal seizures, linear vesicular rash, and unusually early neuroradiological changes: incontinentia pigmenti: a case report, literature review and insight into pathogenesis.
Kaczala GW, Messer MA, Poskitt KJ, Prendiville JS, Gardiner J, Senger C
Eur J Pediatr 2008 Sep;167(9):979-83. Epub 2007 Oct 16 doi: 10.1007/s00431-007-0618-5. PMID: 17938957
Epilepsy with typical absence seizures with onset during the first year of life.
Cavazzuti GB, Ferrari F, Galli V, Benatti A
Epilepsia 1989 Nov-Dec;30(6):802-6. doi: 10.1111/j.1528-1157.1989.tb05342.x. PMID: 2512115

Prognosis

Early-onset bilateral cerebral arteriopathies: Cohort study of phenotype and disease course.
Al-Yassin A, Saunders DE, Mackay MT, Ganesan V
Neurology 2015 Sep 29;85(13):1146-53. Epub 2015 Aug 28 doi: 10.1212/WNL.0000000000001969. PMID: 26320201
Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.
Mercimek-Mahmutoglu S, Horvath GA, Coulter-Mackie M, Nelson T, Waters PJ, Sargent M, Struys E, Jakobs C, Stockler-Ipsiroglu S, Connolly MB
Pediatrics 2012 May;129(5):e1368-72. Epub 2012 Apr 23 doi: 10.1542/peds.2011-0123. PMID: 22529283
Absence seizures in the first 3 years of life: an electroclinical study of 46 cases.
Caraballo RH, Darra F, Fontana E, Garcia R, Monese E, Dalla Bernardina B
Epilepsia 2011 Feb;52(2):393-400. Epub 2011 Jan 26 doi: 10.1111/j.1528-1167.2010.02926.x. PMID: 21269284
Epidemiology of absence epilepsy: EEG findings and their predictive value.
Hedström A, Olsson I
Pediatr Neurol 1991 Mar-Apr;7(2):100-4. doi: 10.1016/0887-8994(91)90004-5. PMID: 1905542
Bilateral symmetrical middle cranial fossa arachnoid cysts in a neonate.
Shirane R, Tanaka T, Andoh A, Suzuki J
Surg Neurol 1986 Oct;26(4):395-8. doi: 10.1016/0090-3019(86)90144-8. PMID: 3750199

Clinical prediction guides

Early-onset bilateral cerebral arteriopathies: Cohort study of phenotype and disease course.
Al-Yassin A, Saunders DE, Mackay MT, Ganesan V
Neurology 2015 Sep 29;85(13):1146-53. Epub 2015 Aug 28 doi: 10.1212/WNL.0000000000001969. PMID: 26320201
Benign neonatal sleep myoclonus: experience from the study of 38 infants.
Paro-Panjan D, Neubauer D
Eur J Paediatr Neurol 2008 Jan;12(1):14-8. Epub 2007 Jun 18 doi: 10.1016/j.ejpn.2007.05.002. PMID: 17574462
Electroclinical signs of benign neonatal familial convulsions.
Hirsch E, Velez A, Sellal F, Maton B, Grinspan A, Malafosse A, Marescaux C
Ann Neurol 1993 Dec;34(6):835-41. doi: 10.1002/ana.410340613. PMID: 8250533
Epidemiology of absence epilepsy: EEG findings and their predictive value.
Hedström A, Olsson I
Pediatr Neurol 1991 Mar-Apr;7(2):100-4. doi: 10.1016/0887-8994(91)90004-5. PMID: 1905542
Bilateral symmetrical middle cranial fossa arachnoid cysts in a neonate.
Shirane R, Tanaka T, Andoh A, Suzuki J
Surg Neurol 1986 Oct;26(4):395-8. doi: 10.1016/0090-3019(86)90144-8. PMID: 3750199

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