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Advanced Undifferentiated Pleomorphic Sarcoma

MedGen UID:
1715501
Concept ID:
C5237456
Neoplastic Process

Definition

An undifferentiated pleomorphic sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Undifferentiated Pleomorphic Sarcoma

Professional guidelines

PubMed

Albarrán V, Villamayor ML, Chamorro J, Rosero DI, Pozas J, San Román M, Calvo JC, Pérez de Aguado P, Moreno J, Guerrero P, González C, García de Quevedo C, Álvarez-Ballesteros P, Vaz MÁ
Int J Mol Sci 2022 Nov 9;23(22) doi: 10.3390/ijms232213784. PMID: 36430263Free PMC Article
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Thway K, Fisher C
Semin Diagn Pathol 2021 Nov;38(6):170-186. Epub 2021 Sep 29 doi: 10.1053/j.semdp.2021.09.005. PMID: 34602314

Recent clinical studies

Etiology

Somaiah N, Conley AP, Parra ER, Lin H, Amini B, Solis Soto L, Salazar R, Barreto C, Chen H, Gite S, Haymaker C, Nassif EF, Bernatchez C, Mitra A, Livingston JA, Ravi V, Araujo DM, Benjamin R, Patel S, Zarzour MA, Sabir S, Lazar AJ, Wang WL, Daw NC, Zhou X, Roland CL, Cooper ZA, Rodriguez-Canales J, Futreal A, Soria JC, Wistuba II, Hwu P
Lancet Oncol 2022 Sep;23(9):1156-1166. Epub 2022 Aug 4 doi: 10.1016/S1470-2045(22)00392-8. PMID: 35934010
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Tang F, Tie Y, Wei YQ, Tu CQ, Wei XW
Biochim Biophys Acta Rev Cancer 2021 Dec;1876(2):188606. Epub 2021 Aug 8 doi: 10.1016/j.bbcan.2021.188606. PMID: 34371128
Kokkali S, Stravodimou A, Duran-Moreno J, Koufopoulos N, Voutsadakis IA, Digklia A
Expert Rev Anticancer Ther 2021 Jun;21(6):591-604. Epub 2021 Mar 12 doi: 10.1080/14737140.2021.1880327. PMID: 33554686
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article

Diagnosis

Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Hames-Fathi S, Nottley SWG, Pillay N
Histopathology 2022 Jan;80(1):109-121. doi: 10.1111/his.14446. PMID: 34958500
Thway K, Fisher C
Semin Diagn Pathol 2021 Nov;38(6):170-186. Epub 2021 Sep 29 doi: 10.1053/j.semdp.2021.09.005. PMID: 34602314
Karakas C, Christensen P, Baek D, Jung M, Ro JY
Ann Diagn Pathol 2019 Apr;39:118-124. Epub 2018 Dec 18 doi: 10.1016/j.anndiagpath.2018.12.005. PMID: 30661742
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052

Therapy

Somaiah N, Conley AP, Parra ER, Lin H, Amini B, Solis Soto L, Salazar R, Barreto C, Chen H, Gite S, Haymaker C, Nassif EF, Bernatchez C, Mitra A, Livingston JA, Ravi V, Araujo DM, Benjamin R, Patel S, Zarzour MA, Sabir S, Lazar AJ, Wang WL, Daw NC, Zhou X, Roland CL, Cooper ZA, Rodriguez-Canales J, Futreal A, Soria JC, Wistuba II, Hwu P
Lancet Oncol 2022 Sep;23(9):1156-1166. Epub 2022 Aug 4 doi: 10.1016/S1470-2045(22)00392-8. PMID: 35934010
Tang F, Tie Y, Wei YQ, Tu CQ, Wei XW
Biochim Biophys Acta Rev Cancer 2021 Dec;1876(2):188606. Epub 2021 Aug 8 doi: 10.1016/j.bbcan.2021.188606. PMID: 34371128
Demetri GD, Luke JJ, Hollebecque A, Powderly JD 2nd, Spira AI, Subbiah V, Naumovski L, Chen C, Fang H, Lai DW, Yue H, Polepally AR, Purcell JW, Robinson R, Sharma P, Allison JP, Tolcher A, Villalobos VM
Clin Cancer Res 2021 Jul 1;27(13):3556-3566. Epub 2021 Apr 5 doi: 10.1158/1078-0432.CCR-20-4513. PMID: 33820780
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article

Prognosis

Pan M, Zhou MY, Jiang C, Zhang Z, Bui NQ, Bien J, Siy A, Achacoso N, Solorzano AV, Tse P, Chung E, Thomas S, Habel LA, Ganjoo KN
Clin Cancer Res 2024 Jan 17;30(2):413-419. doi: 10.1158/1078-0432.CCR-23-1990. PMID: 37831066Free PMC Article
Negayama T, Ishibashi Y, Nakamura O, Nomura Y, Kaji Y, Yamamoto T
Anticancer Res 2021 Oct;41(10):4885-4894. doi: 10.21873/anticanres.15302. PMID: 34593436
You Y, Shi R, Dai M, Du Z, Tian Z, Xu G, Wang L, Wang Y, Xiao M
Histol Histopathol 2021 Aug;36(8):889-898. Epub 2021 Jul 20 doi: 10.14670/HH-18-359. PMID: 34282850
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article

Clinical prediction guides

Kelly CM, Qin LX, Whiting KA, Richards AL, Avutu V, Chan JE, Chi P, Dickson MA, Gounder MM, Keohan ML, Movva S, Nacev BA, Rosenbaum E, Adamson T, Singer S, Bartlett EK, Crago AM, Yoon SS, Hwang S, Erinjeri JP, Antonescu CR, Tap WD, D'Angelo SP
Clin Cancer Res 2023 Jun 1;29(11):2043-2051. doi: 10.1158/1078-0432.CCR-22-3911. PMID: 36971773Free PMC Article
Graves L, Jeck WR, Grilley-Olson JE
Curr Treat Options Oncol 2023 Mar;24(3):212-228. Epub 2023 Feb 2 doi: 10.1007/s11864-023-01054-7. PMID: 36729198
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Demetri GD, Luke JJ, Hollebecque A, Powderly JD 2nd, Spira AI, Subbiah V, Naumovski L, Chen C, Fang H, Lai DW, Yue H, Polepally AR, Purcell JW, Robinson R, Sharma P, Allison JP, Tolcher A, Villalobos VM
Clin Cancer Res 2021 Jul 1;27(13):3556-3566. Epub 2021 Apr 5 doi: 10.1158/1078-0432.CCR-20-4513. PMID: 33820780
Becerikli M, Wieczorek S, Stricker I, Nambiar S, Rittig A, Epplen JT, Tannapfel A, Lehnhardt M, Steinstraesser L, Jacobsen F
Anticancer Res 2014 Dec;34(12):7119-27. PMID: 25503139

Recent systematic reviews

Mannelli G, Bassani S, Cosi G, Fermi M, Gazzini L, Liberale C, Mazzetti L, Parrinello G, Saibene AM, Molteni G, Comini LV
Eur Arch Otorhinolaryngol 2024 May;281(5):2553-2567. Epub 2024 Feb 21 doi: 10.1007/s00405-024-08477-4. PMID: 38381151
Saerens M, Brusselaers N, Rottey S, Decruyenaere A, Creytens D, Lapeire L
Eur J Cancer 2021 Jul;152:165-182. Epub 2021 Jun 6 doi: 10.1016/j.ejca.2021.04.034. PMID: 34107450
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281

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