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Steroid Resistant Acute Graft Versus Host Disease

MedGen UID:
1716579
•Concept ID:
C5238965
•
Disease or Syndrome

Definition

Acute graft versus host disease that is resistant to treatment with steroids. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteroid Resistant Acute Graft Versus Host Disease

Professional guidelines

PubMed

Treatment of steroid resistant acute graft versus host disease with an anti-CD26 monoclonal antibody-Begelomab.
Bacigalupo A, Angelucci E, Raiola AM, Varaldo R, Di Grazia C, Gualandi F, Benedetti E, Risitano A, Musso M, Zallio F, Ciceri F, Chiusolo P, Sica S, Rambaldi A, Bonifazi F, Parma M, Martino M, Onida F, Iori AP, Selleri C, Borghero C, Bertaina A, Prezioso L, Algeri M, Locatelli F
Bone Marrow Transplant 2020 Aug;55(8):1580-1587. Epub 2020 Mar 13 doi: 10.1038/s41409-020-0855-z. PMID: 32203257
Successful treatment of severe acute intestinal graft-versus-host resistant to systemic and topical steroids with alemtuzumab.
Schnitzler M, Hasskarl J, Egger M, Bertz H, Finke J
Biol Blood Marrow Transplant 2009 Aug;15(8):910-8. doi: 10.1016/j.bbmt.2009.04.002. PMID: 19589480
Monoclonal antibodies in the treatment of steroid-resistant acute graft-versus-host disease.
Tse JC, Moore TB
Pharmacotherapy 1998 Sep-Oct;18(5):988-1000. PMID: 9758310

Recent clinical studies

Etiology

Steroid-Sensitive, but Not Steroid-Dependent or Steroid-Resistant Acute Graft-versus-Host Disease, Results in Similar Infection Risk as No Graft-versus-Host Disease following Allogeneic Hematopoietic Cell Transplantation.
Young JH, El Jurdi N, Rayes A, MacMillan ML, Holtan SG, Cao Q, Witte J, Arora M, Weisdorf DJ
Transplant Cell Ther 2022 Aug;28(8):509.e1-509.e11. Epub 2022 May 14 doi: 10.1016/j.jtct.2022.05.008. PMID: 35577324
Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized, phase 3, open-label trial.
Zhao K, Lin R, Fan Z, Chen X, Wang Y, Huang F, Xu N, Zhang X, Zhang X, Xuan L, Wang S, Lin D, Deng L, Nie D, Weng J, Li Y, Zhang X, Li Y, Xiang AP, Liu Q
J Hematol Oncol 2022 Mar 7;15(1):22. doi: 10.1186/s13045-022-01240-4. PMID: 35255929Free PMC Article
Treatment of steroid resistant acute graft versus host disease with an anti-CD26 monoclonal antibody-Begelomab.
Bacigalupo A, Angelucci E, Raiola AM, Varaldo R, Di Grazia C, Gualandi F, Benedetti E, Risitano A, Musso M, Zallio F, Ciceri F, Chiusolo P, Sica S, Rambaldi A, Bonifazi F, Parma M, Martino M, Onida F, Iori AP, Selleri C, Borghero C, Bertaina A, Prezioso L, Algeri M, Locatelli F
Bone Marrow Transplant 2020 Aug;55(8):1580-1587. Epub 2020 Mar 13 doi: 10.1038/s41409-020-0855-z. PMID: 32203257
Ileostomy for steroid-resistant acute graft-versus-host disease of the gastrointestinal tract.
Turki AT, Bayraktar E, Basu O, Benkö T, Yi JH, Kehrmann J, Tzalavras A, Liebregts T, Beelen DW, Steckel NK
Ann Hematol 2019 Oct;98(10):2407-2419. Epub 2019 Jul 23 doi: 10.1007/s00277-019-03754-3. PMID: 31338570Free PMC Article
Efficacy and safety of intra-arterial steroid infusions in patients with steroid-resistant gastrointestinal acute graft-versus-host disease.
Nishimoto M, Koh H, Hirose A, Nakamae M, Nakane T, Hayashi Y, Okamura H, Yoshimura T, Koh S, Nanno S, Nakashima Y, Takeshita T, Yamamoto A, Sakai Y, Nishida N, Matsuoka T, Miki Y, Hino M, Nakamae H
Exp Hematol 2015 Dec;43(12):995-1000. Epub 2015 Aug 22 doi: 10.1016/j.exphem.2015.08.002. PMID: 26303639

Diagnosis

Steroid-Sensitive, but Not Steroid-Dependent or Steroid-Resistant Acute Graft-versus-Host Disease, Results in Similar Infection Risk as No Graft-versus-Host Disease following Allogeneic Hematopoietic Cell Transplantation.
Young JH, El Jurdi N, Rayes A, MacMillan ML, Holtan SG, Cao Q, Witte J, Arora M, Weisdorf DJ
Transplant Cell Ther 2022 Aug;28(8):509.e1-509.e11. Epub 2022 May 14 doi: 10.1016/j.jtct.2022.05.008. PMID: 35577324
Ruxolitinib Inhibits IFNγ Licensing of Human Bone Marrow Derived Mesenchymal Stromal Cells.
Ryan MM, Patel M, Hogan K, Lipat AJ, Scandolara R, Das R, Bruker C, Galipeau J, Chinnadurai R
Transplant Cell Ther 2021 May;27(5):389.e1-389.e10. Epub 2021 Feb 4 doi: 10.1016/j.jtct.2021.02.002. PMID: 33965175Free PMC Article
Mesenchymal stromal cells from pooled mononuclear cells of multiple bone marrow donors as rescue therapy in pediatric severe steroid-refractory graft-versus-host disease: a multicenter survey.
Kuçi Z, Bönig H, Kreyenberg H, Bunos M, Jauch A, Janssen JW, Škifić M, Michel K, Eising B, Lucchini G, Bakhtiar S, Greil J, Lang P, Basu O, von Luettichau I, Schulz A, Sykora KW, Jarisch A, Soerensen J, Salzmann-Manrique E, Seifried E, Klingebiel T, Bader P, Kuçi S
Haematologica 2016 Aug;101(8):985-94. Epub 2016 May 12 doi: 10.3324/haematol.2015.140368. PMID: 27175026Free PMC Article
T-cell chimerism is valuable in predicting early mortality in steroid-resistant acute graft-versus-host disease after myeloablative allogeneic cell transplantation.
Minculescu L, Madsen HO, Sengeløv H
Acta Haematol 2014;132(2):187-92. doi: 10.1159/000357728. PMID: 24603448

Therapy

Steroid-Sensitive, but Not Steroid-Dependent or Steroid-Resistant Acute Graft-versus-Host Disease, Results in Similar Infection Risk as No Graft-versus-Host Disease following Allogeneic Hematopoietic Cell Transplantation.
Young JH, El Jurdi N, Rayes A, MacMillan ML, Holtan SG, Cao Q, Witte J, Arora M, Weisdorf DJ
Transplant Cell Ther 2022 Aug;28(8):509.e1-509.e11. Epub 2022 May 14 doi: 10.1016/j.jtct.2022.05.008. PMID: 35577324
Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized, phase 3, open-label trial.
Zhao K, Lin R, Fan Z, Chen X, Wang Y, Huang F, Xu N, Zhang X, Zhang X, Xuan L, Wang S, Lin D, Deng L, Nie D, Weng J, Li Y, Zhang X, Li Y, Xiang AP, Liu Q
J Hematol Oncol 2022 Mar 7;15(1):22. doi: 10.1186/s13045-022-01240-4. PMID: 35255929Free PMC Article
Treatment of steroid resistant acute graft versus host disease with an anti-CD26 monoclonal antibody-Begelomab.
Bacigalupo A, Angelucci E, Raiola AM, Varaldo R, Di Grazia C, Gualandi F, Benedetti E, Risitano A, Musso M, Zallio F, Ciceri F, Chiusolo P, Sica S, Rambaldi A, Bonifazi F, Parma M, Martino M, Onida F, Iori AP, Selleri C, Borghero C, Bertaina A, Prezioso L, Algeri M, Locatelli F
Bone Marrow Transplant 2020 Aug;55(8):1580-1587. Epub 2020 Mar 13 doi: 10.1038/s41409-020-0855-z. PMID: 32203257
Ileostomy for steroid-resistant acute graft-versus-host disease of the gastrointestinal tract.
Turki AT, Bayraktar E, Basu O, Benkö T, Yi JH, Kehrmann J, Tzalavras A, Liebregts T, Beelen DW, Steckel NK
Ann Hematol 2019 Oct;98(10):2407-2419. Epub 2019 Jul 23 doi: 10.1007/s00277-019-03754-3. PMID: 31338570Free PMC Article
Mesenchymal stromal cells and hematopoietic stem cell transplantation.
Bernardo ME, Fibbe WE
Immunol Lett 2015 Dec;168(2):215-21. Epub 2015 Jun 25 doi: 10.1016/j.imlet.2015.06.013. PMID: 26116911

Prognosis

Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study.
Bloor AJC, Patel A, Griffin JE, Gilleece MH, Radia R, Yeung DT, Drier D, Larson LS, Uenishi GI, Hei D, Kelly K, Slukvin I, Rasko JEJ
Nat Med 2020 Nov;26(11):1720-1725. Epub 2020 Sep 14 doi: 10.1038/s41591-020-1050-x. PMID: 32929265
α(1)-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease.
Magenau JM, Goldstein SC, Peltier D, Soiffer RJ, Braun T, Pawarode A, Riwes MM, Kennel M, Antin JH, Cutler CS, Ho VT, Alyea EP 3rd, Parkin BL, Yanik GA, Choi SW, Lewis EC, Dinarello CA, Koreth J, Reddy P
Blood 2018 Mar 22;131(12):1372-1379. Epub 2018 Feb 2 doi: 10.1182/blood-2017-11-815746. PMID: 29437593Free PMC Article
Efficacy and safety of intra-arterial steroid infusions in patients with steroid-resistant gastrointestinal acute graft-versus-host disease.
Nishimoto M, Koh H, Hirose A, Nakamae M, Nakane T, Hayashi Y, Okamura H, Yoshimura T, Koh S, Nanno S, Nakashima Y, Takeshita T, Yamamoto A, Sakai Y, Nishida N, Matsuoka T, Miki Y, Hino M, Nakamae H
Exp Hematol 2015 Dec;43(12):995-1000. Epub 2015 Aug 22 doi: 10.1016/j.exphem.2015.08.002. PMID: 26303639
Treatment of steroid-resistant acute graft-versus-host disease with anti-thymocyte globulin.
Khoury H, Kashyap A, Adkins DR, Brown RA, Miller G, Vij R, Westervelt P, Trinkaus K, Goodnough LT, Hayashi RJ, Parker P, Forman SJ, DiPersio JF
Bone Marrow Transplant 2001 May;27(10):1059-64. doi: 10.1038/sj.bmt.1703032. PMID: 11438821
Treatment of steroid-resistant acute graft-versus-host disease with rabbit antithymocyte globulin.
McCaul KG, Nevill TJ, Barnett MJ, Toze CL, Currie CJ, Sutherland HJ, Conneally EA, Shepherd JD, Nantel SH, Hogge DE, Klingemann HG
J Hematother Stem Cell Res 2000 Jun;9(3):367-74. doi: 10.1089/15258160050079470. PMID: 10894358

Clinical prediction guides

Steroid-Sensitive, but Not Steroid-Dependent or Steroid-Resistant Acute Graft-versus-Host Disease, Results in Similar Infection Risk as No Graft-versus-Host Disease following Allogeneic Hematopoietic Cell Transplantation.
Young JH, El Jurdi N, Rayes A, MacMillan ML, Holtan SG, Cao Q, Witte J, Arora M, Weisdorf DJ
Transplant Cell Ther 2022 Aug;28(8):509.e1-509.e11. Epub 2022 May 14 doi: 10.1016/j.jtct.2022.05.008. PMID: 35577324
Ileostomy for steroid-resistant acute graft-versus-host disease of the gastrointestinal tract.
Turki AT, Bayraktar E, Basu O, Benkö T, Yi JH, Kehrmann J, Tzalavras A, Liebregts T, Beelen DW, Steckel NK
Ann Hematol 2019 Oct;98(10):2407-2419. Epub 2019 Jul 23 doi: 10.1007/s00277-019-03754-3. PMID: 31338570Free PMC Article
α(1)-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease.
Magenau JM, Goldstein SC, Peltier D, Soiffer RJ, Braun T, Pawarode A, Riwes MM, Kennel M, Antin JH, Cutler CS, Ho VT, Alyea EP 3rd, Parkin BL, Yanik GA, Choi SW, Lewis EC, Dinarello CA, Koreth J, Reddy P
Blood 2018 Mar 22;131(12):1372-1379. Epub 2018 Feb 2 doi: 10.1182/blood-2017-11-815746. PMID: 29437593Free PMC Article
Successful treatment of severe acute intestinal graft-versus-host resistant to systemic and topical steroids with alemtuzumab.
Schnitzler M, Hasskarl J, Egger M, Bertz H, Finke J
Biol Blood Marrow Transplant 2009 Aug;15(8):910-8. doi: 10.1016/j.bbmt.2009.04.002. PMID: 19589480
Treatment of steroid-resistant acute graft-versus-host disease with anti-thymocyte globulin.
Khoury H, Kashyap A, Adkins DR, Brown RA, Miller G, Vij R, Westervelt P, Trinkaus K, Goodnough LT, Hayashi RJ, Parker P, Forman SJ, DiPersio JF
Bone Marrow Transplant 2001 May;27(10):1059-64. doi: 10.1038/sj.bmt.1703032. PMID: 11438821

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