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Aggressive Prostate Adenocarcinoma

MedGen UID:
1717379
•Concept ID:
C5236043
•
Neoplastic Process

Definition

Prostate adenocarcinoma that metastasizes quickly to other anatomic sites. It usually has a Gleason score between 8 and 10, a PSA level higher than 20 ng/ml, and is classified as T3b or T4. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggressive Prostate Adenocarcinoma

Professional guidelines

PubMed

Whole pelvic radiotherapy versus prostate only radiotherapy in the management of locally advanced or aggressive prostate adenocarcinoma.
Aizer AA, Yu JB, McKeon AM, Decker RH, Colberg JW, Peschel RE
Int J Radiat Oncol Biol Phys 2009 Dec 1;75(5):1344-9. Epub 2009 May 21 doi: 10.1016/j.ijrobp.2008.12.082. PMID: 19464821

Recent clinical studies

Etiology

A multicentric, single arm, open-label, phase I/II study evaluating PSMA targeted radionuclide therapy in adult patients with metastatic clear cell renal cancer (PRadR).
Kryza D, Vinceneux A, Bidaux AS, Garin G, Tatu D, Cropet C, Badel JN, Perol D, Giraudet AL
BMC Cancer 2024 Feb 1;24(1):163. doi: 10.1186/s12885-023-11702-8. PMID: 38302933Free PMC Article
PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma.
Balraj AS, Muthamilselvan S, Raja R, Palaniappan A
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338231222389. doi: 10.1177/15330338231222389. PMID: 38226611Free PMC Article
Is there any prognostic impact of intraductal carcinoma of prostate in initial diagnosed aggressively metastatic prostate cancer?
Zhao T, Liao B, Yao J, Liu J, Huang R, Shen P, Peng Z, Gui H, Chen X, Zhang P, Zhu Y, Li X, Wei Q, Zhou Q, Zeng H, Chen N
Prostate 2015 Feb 15;75(3):225-32. Epub 2014 Oct 13 doi: 10.1002/pros.22906. PMID: 25307858
Whole pelvic radiotherapy versus prostate only radiotherapy in the management of locally advanced or aggressive prostate adenocarcinoma.
Aizer AA, Yu JB, McKeon AM, Decker RH, Colberg JW, Peschel RE
Int J Radiat Oncol Biol Phys 2009 Dec 1;75(5):1344-9. Epub 2009 May 21 doi: 10.1016/j.ijrobp.2008.12.082. PMID: 19464821

Diagnosis

PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma.
Balraj AS, Muthamilselvan S, Raja R, Palaniappan A
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338231222389. doi: 10.1177/15330338231222389. PMID: 38226611Free PMC Article
Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence.
Bainor AJ, Deng FM, Wang Y, Lee P, Cantor DJ, Logan SK, David G
Cancer Res 2017 Oct 1;77(19):5339-5348. Epub 2017 Aug 14 doi: 10.1158/0008-5472.CAN-16-3410. PMID: 28807943Free PMC Article
Is there any prognostic impact of intraductal carcinoma of prostate in initial diagnosed aggressively metastatic prostate cancer?
Zhao T, Liao B, Yao J, Liu J, Huang R, Shen P, Peng Z, Gui H, Chen X, Zhang P, Zhu Y, Li X, Wei Q, Zhou Q, Zeng H, Chen N
Prostate 2015 Feb 15;75(3):225-32. Epub 2014 Oct 13 doi: 10.1002/pros.22906. PMID: 25307858
Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer.
Wu C, Wyatt AW, Lapuk AV, McPherson A, McConeghy BJ, Bell RH, Anderson S, Haegert A, Brahmbhatt S, Shukin R, Mo F, Li E, Fazli L, Hurtado-Coll A, Jones EC, Butterfield YS, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Jones SJ, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Sahinalp SC, Gleave ME, Volik SV, Collins CC
J Pathol 2012 May;227(1):53-61. Epub 2012 Mar 21 doi: 10.1002/path.3987. PMID: 22294438Free PMC Article
Unilateral exophthalmos revealing metastatic prostate cancer.
Adli Oel Y, Elammari JE, Elfassi MJ, Farih MH
Urology 2012 Mar;79(3):e40-1. Epub 2012 Jan 13 doi: 10.1016/j.urology.2011.11.015. PMID: 22245296

Therapy

A multicentric, single arm, open-label, phase I/II study evaluating PSMA targeted radionuclide therapy in adult patients with metastatic clear cell renal cancer (PRadR).
Kryza D, Vinceneux A, Bidaux AS, Garin G, Tatu D, Cropet C, Badel JN, Perol D, Giraudet AL
BMC Cancer 2024 Feb 1;24(1):163. doi: 10.1186/s12885-023-11702-8. PMID: 38302933Free PMC Article
PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma.
Balraj AS, Muthamilselvan S, Raja R, Palaniappan A
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338231222389. doi: 10.1177/15330338231222389. PMID: 38226611Free PMC Article
Whole pelvic radiotherapy versus prostate only radiotherapy in the management of locally advanced or aggressive prostate adenocarcinoma.
Aizer AA, Yu JB, McKeon AM, Decker RH, Colberg JW, Peschel RE
Int J Radiat Oncol Biol Phys 2009 Dec 1;75(5):1344-9. Epub 2009 May 21 doi: 10.1016/j.ijrobp.2008.12.082. PMID: 19464821

Prognosis

PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma.
Balraj AS, Muthamilselvan S, Raja R, Palaniappan A
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338231222389. doi: 10.1177/15330338231222389. PMID: 38226611Free PMC Article
Is there any prognostic impact of intraductal carcinoma of prostate in initial diagnosed aggressively metastatic prostate cancer?
Zhao T, Liao B, Yao J, Liu J, Huang R, Shen P, Peng Z, Gui H, Chen X, Zhang P, Zhu Y, Li X, Wei Q, Zhou Q, Zeng H, Chen N
Prostate 2015 Feb 15;75(3):225-32. Epub 2014 Oct 13 doi: 10.1002/pros.22906. PMID: 25307858
Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer.
Wu C, Wyatt AW, Lapuk AV, McPherson A, McConeghy BJ, Bell RH, Anderson S, Haegert A, Brahmbhatt S, Shukin R, Mo F, Li E, Fazli L, Hurtado-Coll A, Jones EC, Butterfield YS, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Jones SJ, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Sahinalp SC, Gleave ME, Volik SV, Collins CC
J Pathol 2012 May;227(1):53-61. Epub 2012 Mar 21 doi: 10.1002/path.3987. PMID: 22294438Free PMC Article
Whole pelvic radiotherapy versus prostate only radiotherapy in the management of locally advanced or aggressive prostate adenocarcinoma.
Aizer AA, Yu JB, McKeon AM, Decker RH, Colberg JW, Peschel RE
Int J Radiat Oncol Biol Phys 2009 Dec 1;75(5):1344-9. Epub 2009 May 21 doi: 10.1016/j.ijrobp.2008.12.082. PMID: 19464821
Increased hyaluronidase expression in more aggressive prostate adenocarcinoma.
Madan AK, Pang Y, Wilkiemeyer MB, Yu D, Beech DJ
Oncol Rep 1999 Nov-Dec;6(6):1431-3. doi: 10.3892/or.6.6.1431. PMID: 10523725

Clinical prediction guides

PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma.
Balraj AS, Muthamilselvan S, Raja R, Palaniappan A
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338231222389. doi: 10.1177/15330338231222389. PMID: 38226611Free PMC Article
Is there any prognostic impact of intraductal carcinoma of prostate in initial diagnosed aggressively metastatic prostate cancer?
Zhao T, Liao B, Yao J, Liu J, Huang R, Shen P, Peng Z, Gui H, Chen X, Zhang P, Zhu Y, Li X, Wei Q, Zhou Q, Zeng H, Chen N
Prostate 2015 Feb 15;75(3):225-32. Epub 2014 Oct 13 doi: 10.1002/pros.22906. PMID: 25307858
Whole pelvic radiotherapy versus prostate only radiotherapy in the management of locally advanced or aggressive prostate adenocarcinoma.
Aizer AA, Yu JB, McKeon AM, Decker RH, Colberg JW, Peschel RE
Int J Radiat Oncol Biol Phys 2009 Dec 1;75(5):1344-9. Epub 2009 May 21 doi: 10.1016/j.ijrobp.2008.12.082. PMID: 19464821
Increased hyaluronidase expression in more aggressive prostate adenocarcinoma.
Madan AK, Pang Y, Wilkiemeyer MB, Yu D, Beech DJ
Oncol Rep 1999 Nov-Dec;6(6):1431-3. doi: 10.3892/or.6.6.1431. PMID: 10523725

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