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Recurrent Transformed Mycosis Fungoides

MedGen UID:
1717702
•Concept ID:
C5237458
•
Neoplastic Process
Synonym: Recurrent T-MF

Definition

The reemergence of transformed mycosis fungoides after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Transformed Mycosis Fungoides

Professional guidelines

PubMed

Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970

Recent clinical studies

Etiology

What factors guide treatment selection in mycosis fungoides and Sezary syndrome?
Kim YH
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):303-312. doi: 10.1182/hematology.2021000263. PMID: 34889422Free PMC Article
Mycosis Fungoides: A 10-year Turkish Experience.
Baykal Selcuk L, Aksu Arica D, Yayli S, Seyman Ü, Bahadir S
Acta Dermatovenerol Croat 2019 Sep;27(3):153-158. PMID: 31542058
Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi-ethnic Asian cohort: a 12-year review.
Lim HLJ, Tan EST, Tee SI, Ho ZY, Boey JJJ, Tan WP, Tang MBY, Shen L, Chan YH, Tan SH
J Eur Acad Dermatol Venereol 2019 Aug;33(8):1513-1521. Epub 2019 Mar 27 doi: 10.1111/jdv.15526. PMID: 30801779
Folliculotropic mycosis fungoides presenting with a solitary lesion: Clinicopathological features and long-term follow-up data in a series of 9 cases.
van Santen S, Jansen PM, Vermeer MH, Willemze R
J Cutan Pathol 2018 Feb;45(2):122-128. Epub 2017 Dec 11 doi: 10.1111/cup.13077. PMID: 29086994
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970

Diagnosis

Mycosis Fungoides: A 10-year Turkish Experience.
Baykal Selcuk L, Aksu Arica D, Yayli S, Seyman Ü, Bahadir S
Acta Dermatovenerol Croat 2019 Sep;27(3):153-158. PMID: 31542058
Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi-ethnic Asian cohort: a 12-year review.
Lim HLJ, Tan EST, Tee SI, Ho ZY, Boey JJJ, Tan WP, Tang MBY, Shen L, Chan YH, Tan SH
J Eur Acad Dermatol Venereol 2019 Aug;33(8):1513-1521. Epub 2019 Mar 27 doi: 10.1111/jdv.15526. PMID: 30801779
Folliculotropic mycosis fungoides presenting with a solitary lesion: Clinicopathological features and long-term follow-up data in a series of 9 cases.
van Santen S, Jansen PM, Vermeer MH, Willemze R
J Cutan Pathol 2018 Feb;45(2):122-128. Epub 2017 Dec 11 doi: 10.1111/cup.13077. PMID: 29086994
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis.
Karai LJ, Kadin ME, Hsi ED, Sluzevich JC, Ketterling RP, Knudson RA, Feldman AL
Am J Surg Pathol 2013 Aug;37(8):1173-81. doi: 10.1097/PAS.0b013e318282d01e. PMID: 23648461
Genome-wide analysis of cutaneous T-cell lymphomas identifies three clinically relevant classes.
Laharanne E, Oumouhou N, Bonnet F, Carlotti M, Gentil C, Chevret E, Jouary T, Longy M, Vergier B, Beylot-Barry M, Merlio JP
J Invest Dermatol 2010 Jun;130(6):1707-18. Epub 2010 Feb 4 doi: 10.1038/jid.2010.8. PMID: 20130593

Therapy

Pooled analysis of pralatrexate single-agent studies in patients with relapsed/refractory peripheral T-cell lymphoma.
O'Connor OA, Ko BS, Wang MC, Maruyama D, Song Y, Yeoh EM, Manamley N, Tobinai K
Blood Adv 2024 Jun 11;8(11):2601-2611. doi: 10.1182/bloodadvances.2023010441. PMID: 38429077
Pembrolizumab in mycosis fungoides with PD-L1 structural variants.
Beygi S, Fernandez-Pol S, Duran G, Wang EB, Stehr H, Zehnder JL, Ramchurren N, Fling SP, Cheever MA, Weng WK, Kim YH, Khodadoust MS
Blood Adv 2021 Feb 9;5(3):771-774. doi: 10.1182/bloodadvances.2020002371. PMID: 33560388Free PMC Article
All-oral metronomic DEVEC schedule in elderly patients with peripheral T cell lymphoma.
Cox MC, Banchi M, Pelliccia S, Di Napoli A, Marcheselli L, Patti C, Anticoli Borza P, Battistini R, Di Gregorio F, Orlandi P, Bocci G
Cancer Chemother Pharmacol 2020 Dec;86(6):841-846. Epub 2020 Oct 18 doi: 10.1007/s00280-020-04172-3. PMID: 33070248Free PMC Article
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970
Total skin electron beam and non-myeloablative allogeneic hematopoietic stem-cell transplantation in advanced mycosis fungoides and Sezary syndrome.
Duvic M, Donato M, Dabaja B, Richmond H, Singh L, Wei W, Acholonu S, Khouri I, Champlin R, Hosing C
J Clin Oncol 2010 May 10;28(14):2365-72. Epub 2010 Mar 29 doi: 10.1200/JCO.2009.25.8301. PMID: 20351328

Prognosis

What factors guide treatment selection in mycosis fungoides and Sezary syndrome?
Kim YH
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):303-312. doi: 10.1182/hematology.2021000263. PMID: 34889422Free PMC Article
Mycosis Fungoides: A 10-year Turkish Experience.
Baykal Selcuk L, Aksu Arica D, Yayli S, Seyman Ü, Bahadir S
Acta Dermatovenerol Croat 2019 Sep;27(3):153-158. PMID: 31542058
Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multi-ethnic Asian cohort: a 12-year review.
Lim HLJ, Tan EST, Tee SI, Ho ZY, Boey JJJ, Tan WP, Tang MBY, Shen L, Chan YH, Tan SH
J Eur Acad Dermatol Venereol 2019 Aug;33(8):1513-1521. Epub 2019 Mar 27 doi: 10.1111/jdv.15526. PMID: 30801779
Folliculotropic mycosis fungoides presenting with a solitary lesion: Clinicopathological features and long-term follow-up data in a series of 9 cases.
van Santen S, Jansen PM, Vermeer MH, Willemze R
J Cutan Pathol 2018 Feb;45(2):122-128. Epub 2017 Dec 11 doi: 10.1111/cup.13077. PMID: 29086994
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.
Jawed SI, Myskowski PL, Horwitz S, Moskowitz A, Querfeld C
J Am Acad Dermatol 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. PMID: 24438970

Clinical prediction guides

Mycosis Fungoides: A 10-year Turkish Experience.
Baykal Selcuk L, Aksu Arica D, Yayli S, Seyman Ü, Bahadir S
Acta Dermatovenerol Croat 2019 Sep;27(3):153-158. PMID: 31542058
Folliculotropic mycosis fungoides presenting with a solitary lesion: Clinicopathological features and long-term follow-up data in a series of 9 cases.
van Santen S, Jansen PM, Vermeer MH, Willemze R
J Cutan Pathol 2018 Feb;45(2):122-128. Epub 2017 Dec 11 doi: 10.1111/cup.13077. PMID: 29086994
Central nervous system involvement in T-cell lymphoma: A single center experience.
Gurion R, Mehta N, Migliacci JC, Zelenetz A, Moskowitz A, Lunning M, Moskowitz C, Hamlin P, Horwitz S
Acta Oncol 2016 May;55(5):561-6. Epub 2016 Apr 4 doi: 10.3109/0284186X.2015.1118656. PMID: 27046135Free PMC Article
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis.
Karai LJ, Kadin ME, Hsi ED, Sluzevich JC, Ketterling RP, Knudson RA, Feldman AL
Am J Surg Pathol 2013 Aug;37(8):1173-81. doi: 10.1097/PAS.0b013e318282d01e. PMID: 23648461
Common chromosomal abnormalities in mycosis fungoides transformation.
Prochazkova M, Chevret E, Mainhaguiet G, Sobotka J, Vergier B, Belaud-Rotureau MA, Beylot-Barry M, Merlio JP
Genes Chromosomes Cancer 2007 Sep;46(9):828-38. doi: 10.1002/gcc.20469. PMID: 17584911

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