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Trichoblastic Carcinoma

MedGen UID:
1717805
Concept ID:
C4552208
Neoplastic Process

Definition

A rare biphasic malignant neoplasm with dual differentiation towards the specialized follicular stroma and germinative follicular cells, which can be strikingly atypical. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrichoblastic Carcinoma

Professional guidelines

PubMed

SFORL work group, Durbec M, Couloigner V, Tronche S, Albert S, Kanitakis J, Ltaief Boudrigua A, Malard O, Maubec E, Mourrain Langlois E, Navailles B, Peuvrel L, Phulpin B, Thimonier JC, Disant F, Dolivet G
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):375-383. doi: 10.1016/j.anorl.2014.06.002. PMID: 25456243
Fazaa B, Cribier B, Zaraa I, Zermani R, Zeglaoui F, Zouari B, Ben Jilani S, Maalej M, Kamoun MR
Dermatology 2007;215(4):301-7. doi: 10.1159/000107623. PMID: 17911987

Recent clinical studies

Etiology

Toulemonde E, Chevret S, Battistella M, Neidhardt EM, Nardin C, Le Du F, Meyer N, Véron M, Gambotti L, Lamrani-Ghaouti A, Jamme P, Chaffaut C, De Pontville M, Saada-Bouzid E, Beylot-Barry M, Simon C, Jouary T, Marabelle A, Mortier L
Cancer Immunol Immunother 2023 Aug;72(8):2649-2657. Epub 2023 Apr 17 doi: 10.1007/s00262-023-03449-9. PMID: 37067554Free PMC Article
Fernández-Figueras MT, Malvehi J, Tschandl P, Rutten A, Rongioletti F, Requena L, Kittler H, Kerl K, Kazakov D, Cribier B, Calonje E, André J, Kempf W; Study Group Collaborators (Validation Group)
J Eur Acad Dermatol Venereol 2022 Mar;36(3):351-359. Epub 2021 Dec 21 doi: 10.1111/jdv.17849. PMID: 34931722
Mehta A, Davey J, Wiedemeyer K, Brenn T
Histopathology 2021 Jun;78(7):970-975. Epub 2021 Apr 6 doi: 10.1111/his.14325. PMID: 33393120
Müller CS, Schiekofer C, Körner R, Pföhler C, Vogt T
J Dtsch Dermatol Ges 2013 Jun;11(6):537-48. Epub 2013 Mar 6 doi: 10.1111/ddg.12038. PMID: 23464728
Fazaa B, Cribier B, Zaraa I, Zermani R, Zeglaoui F, Zouari B, Ben Jilani S, Maalej M, Kamoun MR
Dermatology 2007;215(4):301-7. doi: 10.1159/000107623. PMID: 17911987

Diagnosis

Weiland T, Sadoghi B, Pondorfer P, Kiss P, Brcic I, Thurnher D
J Dermatol 2023 May;50(5):700-704. Epub 2023 Jan 18 doi: 10.1111/1346-8138.16716. PMID: 36651105
Boettler MA, Shahwan KT, Abidi NY, Carr DR
Arch Dermatol Res 2022 Jul;314(5):399-403. Epub 2021 May 15 doi: 10.1007/s00403-021-02241-y. PMID: 33993349
Mehta A, Davey J, Wiedemeyer K, Brenn T
Histopathology 2021 Jun;78(7):970-975. Epub 2021 Apr 6 doi: 10.1111/his.14325. PMID: 33393120
Karimzadeh I, Namazi MR, Karimzadeh A
Acta Dermatovenerol Croat 2018 Jun;26(2):162-165. PMID: 29989874
Laffay L, Depaepe L, d'Hombres A, Balme B, Thomas L, De Bari B
Tumori 2012 Mar-Apr;98(2):46e-49e. doi: 10.1700/1088.11948. PMID: 22678003

Therapy

Toulemonde E, Chevret S, Battistella M, Neidhardt EM, Nardin C, Le Du F, Meyer N, Véron M, Gambotti L, Lamrani-Ghaouti A, Jamme P, Chaffaut C, De Pontville M, Saada-Bouzid E, Beylot-Barry M, Simon C, Jouary T, Marabelle A, Mortier L
Cancer Immunol Immunother 2023 Aug;72(8):2649-2657. Epub 2023 Apr 17 doi: 10.1007/s00262-023-03449-9. PMID: 37067554Free PMC Article
Duplaine A, Beylot-Barry M, Mansard S, Arnault JP, Grob JJ, Maillard H, Saiag P, Poulalhon N, Cribier B, Mortier L, Battistella M, Jouary T
J Am Acad Dermatol 2022 Jun;86(6):1365-1366. Epub 2021 May 27 doi: 10.1016/j.jaad.2021.05.024. PMID: 34052337
Lepesant P, Crinquette M, Alkeraye S, Mirabel X, Dziwniel V, Cribier B, Mortier L
Br J Dermatol 2015 Oct;173(4):1059-62. Epub 2015 Aug 27 doi: 10.1111/bjd.13919. PMID: 25998864
Battistella M, Mateus C, Lassau N, Chami L, Boukoucha M, Duvillard P, Cribier B, Robert C
J Eur Acad Dermatol Venereol 2010 Feb;24(2):199-203. Epub 2009 Jun 8 doi: 10.1111/j.1468-3083.2009.03301.x. PMID: 19522717
Fazaa B, Cribier B, Zaraa I, Zermani R, Zeglaoui F, Zouari B, Ben Jilani S, Maalej M, Kamoun MR
Dermatology 2007;215(4):301-7. doi: 10.1159/000107623. PMID: 17911987

Prognosis

Fernández-Figueras MT, Malvehi J, Tschandl P, Rutten A, Rongioletti F, Requena L, Kittler H, Kerl K, Kazakov D, Cribier B, Calonje E, André J, Kempf W; Study Group Collaborators (Validation Group)
J Eur Acad Dermatol Venereol 2022 Mar;36(3):351-359. Epub 2021 Dec 21 doi: 10.1111/jdv.17849. PMID: 34931722
Mehta A, Davey J, Wiedemeyer K, Brenn T
Histopathology 2021 Jun;78(7):970-975. Epub 2021 Apr 6 doi: 10.1111/his.14325. PMID: 33393120
Toberer F, Rütten A, Requena L, Kazakov DV, Enk A, Hartschuh W, Haenssle HA
J Cutan Pathol 2017 Nov;44(11):986-990. Epub 2017 Sep 4 doi: 10.1111/cup.13031. PMID: 28869314
Battistella M, Mateus C, Lassau N, Chami L, Boukoucha M, Duvillard P, Cribier B, Robert C
J Eur Acad Dermatol Venereol 2010 Feb;24(2):199-203. Epub 2009 Jun 8 doi: 10.1111/j.1468-3083.2009.03301.x. PMID: 19522717
Fazaa B, Cribier B, Zaraa I, Zermani R, Zeglaoui F, Zouari B, Ben Jilani S, Maalej M, Kamoun MR
Dermatology 2007;215(4):301-7. doi: 10.1159/000107623. PMID: 17911987

Clinical prediction guides

Toulemonde E, Chevret S, Battistella M, Neidhardt EM, Nardin C, Le Du F, Meyer N, Véron M, Gambotti L, Lamrani-Ghaouti A, Jamme P, Chaffaut C, De Pontville M, Saada-Bouzid E, Beylot-Barry M, Simon C, Jouary T, Marabelle A, Mortier L
Cancer Immunol Immunother 2023 Aug;72(8):2649-2657. Epub 2023 Apr 17 doi: 10.1007/s00262-023-03449-9. PMID: 37067554Free PMC Article
Lepesant P, Crinquette M, Alkeraye S, Mirabel X, Dziwniel V, Cribier B, Mortier L
Br J Dermatol 2015 Oct;173(4):1059-62. Epub 2015 Aug 27 doi: 10.1111/bjd.13919. PMID: 25998864
Müller CS, Schiekofer C, Körner R, Pföhler C, Vogt T
J Dtsch Dermatol Ges 2013 Jun;11(6):537-48. Epub 2013 Mar 6 doi: 10.1111/ddg.12038. PMID: 23464728
Battistella M, Mateus C, Lassau N, Chami L, Boukoucha M, Duvillard P, Cribier B, Robert C
J Eur Acad Dermatol Venereol 2010 Feb;24(2):199-203. Epub 2009 Jun 8 doi: 10.1111/j.1468-3083.2009.03301.x. PMID: 19522717

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