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Abnormal cellular composition of bronchoalveolar fluid

MedGen UID:
1718141
•Concept ID:
C5397966
•
Finding
Synonym: Abnormal cell differential of broncho-alveolar fluid
 
HPO: HP:0032974

Definition

Deviation from the commonly in healthy people observe cellular distribution. Normal ranges are macrophages over 80%, lymphocytes less than 15%, neutrophils less than 3%, eosinophils less than 0.5%, mast cells less than 0.5%. [from HPO]

Recent clinical studies

Etiology

Evaluation of the airway microbiome in nontuberculous mycobacteria disease.
Sulaiman I, Wu BG, Li Y, Scott AS, Malecha P, Scaglione B, Wang J, Basavaraj A, Chung S, Bantis K, Carpenito J, Clemente JC, Shen N, Bessich J, Rafeq S, Michaud G, Donington J, Naidoo C, Theron G, Schattner G, Garofano S, Condos R, Kamelhar D, Addrizzo-Harris D, Segal LN
Eur Respir J 2018 Oct;52(4) Epub 2018 Oct 25 doi: 10.1183/13993003.00810-2018. PMID: 30093571
Surfactant proteins in pulmonary alveolar proteinosis in adults.
Brasch F, Birzele J, Ochs M, Guttentag SH, Schoch OD, Boehler A, Beers MF, Müller KM, Hawgood S, Johnen G
Eur Respir J 2004 Sep;24(3):426-35. doi: 10.1183/09031936.04.00076403. PMID: 15358702
Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infections.
Mander A, Langton-Hewer S, Bernhard W, Warner JO, Postle AD
Am J Respir Cell Mol Biol 2002 Dec;27(6):714-21. doi: 10.1165/rcmb.4746. PMID: 12444031
Abnormal lipid composition of bronchoalveolar lavage fluid obtained from individuals with AIDS-related lung disease.
Rose RM, Catalano PJ, Koziel H, Furlong ST
Am J Respir Crit Care Med 1994 Feb;149(2 Pt 1):332-8. doi: 10.1164/ajrccm.149.2.8306026. PMID: 8306026
Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis.
Ohar JA, Jackson F, Dettenmeier PA, Bedrossian CW, Tricomi SM, Evans RG
Chest 1992 Oct;102(4):999-1004. doi: 10.1378/chest.102.4.999. PMID: 1395816

Diagnosis

Evaluation of the airway microbiome in nontuberculous mycobacteria disease.
Sulaiman I, Wu BG, Li Y, Scott AS, Malecha P, Scaglione B, Wang J, Basavaraj A, Chung S, Bantis K, Carpenito J, Clemente JC, Shen N, Bessich J, Rafeq S, Michaud G, Donington J, Naidoo C, Theron G, Schattner G, Garofano S, Condos R, Kamelhar D, Addrizzo-Harris D, Segal LN
Eur Respir J 2018 Oct;52(4) Epub 2018 Oct 25 doi: 10.1183/13993003.00810-2018. PMID: 30093571
Proteomics as the tool to search for lung disease markers in bronchoalveolar lavage.
Noël-Georis I, Bernard A, Falmagne P, Wattiez R
Dis Markers 2001;17(4):271-84. doi: 10.1155/2001/607263. PMID: 11790894Free PMC Article
Amiodarone pulmonary toxicity: a multidisciplinary review of current status.
Fraire AE, Guntupalli KK, Greenberg SD, Cartwright J Jr, Chasen MH
South Med J 1993 Jan;86(1):67-77. PMID: 8420020
Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis.
Ohar JA, Jackson F, Dettenmeier PA, Bedrossian CW, Tricomi SM, Evans RG
Chest 1992 Oct;102(4):999-1004. doi: 10.1378/chest.102.4.999. PMID: 1395816
The surfactant system of the adult lung: physiology and clinical perspectives.
Hamm H, Fabel H, Bartsch W
Clin Investig 1992 Aug;70(8):637-57. doi: 10.1007/BF00180279. PMID: 1392439Free PMC Article

Therapy

Amiodarone pulmonary toxicity: a multidisciplinary review of current status.
Fraire AE, Guntupalli KK, Greenberg SD, Cartwright J Jr, Chasen MH
South Med J 1993 Jan;86(1):67-77. PMID: 8420020
Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis.
Ohar JA, Jackson F, Dettenmeier PA, Bedrossian CW, Tricomi SM, Evans RG
Chest 1992 Oct;102(4):999-1004. doi: 10.1378/chest.102.4.999. PMID: 1395816
The surfactant system of the adult lung: physiology and clinical perspectives.
Hamm H, Fabel H, Bartsch W
Clin Investig 1992 Aug;70(8):637-57. doi: 10.1007/BF00180279. PMID: 1392439Free PMC Article
Idiopathic pulmonary fibrosis. Abnormalities in bronchoalveolar lavage fluid phospholipids.
Robinson PC, Watters LC, King TE, Mason RJ
Am Rev Respir Dis 1988 Mar;137(3):585-91. doi: 10.1164/ajrccm/137.3.585. PMID: 3345040
Idiopathic pulmonary fibrosis. Pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy.
Watters LC, Schwarz MI, Cherniack RM, Waldron JA, Dunn TL, Stanford RE, King TE
Am Rev Respir Dis 1987 Mar;135(3):696-704. doi: 10.1164/arrd.1987.135.3.696. PMID: 3826895

Prognosis

Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infections.
Mander A, Langton-Hewer S, Bernhard W, Warner JO, Postle AD
Am J Respir Cell Mol Biol 2002 Dec;27(6):714-21. doi: 10.1165/rcmb.4746. PMID: 12444031
Amiodarone pulmonary toxicity: a multidisciplinary review of current status.
Fraire AE, Guntupalli KK, Greenberg SD, Cartwright J Jr, Chasen MH
South Med J 1993 Jan;86(1):67-77. PMID: 8420020
Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis.
Ohar JA, Jackson F, Dettenmeier PA, Bedrossian CW, Tricomi SM, Evans RG
Chest 1992 Oct;102(4):999-1004. doi: 10.1378/chest.102.4.999. PMID: 1395816
Bronchoalveolar lavage cell and lymphocyte phenotype profiles in healthy asbestos-exposed shipyard workers.
Wallace JM, Oishi JS, Barbers RG, Batra P, Aberle DR
Am Rev Respir Dis 1989 Jan;139(1):33-8. doi: 10.1164/ajrccm/139.1.33. PMID: 2912354
Fetal lung development in the diabetic pregnancy.
Bourbon JR, Farrell PM
Pediatr Res 1985 Mar;19(3):253-67. doi: 10.1203/00006450-198503000-00001. PMID: 3885150

Clinical prediction guides

Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infections.
Mander A, Langton-Hewer S, Bernhard W, Warner JO, Postle AD
Am J Respir Cell Mol Biol 2002 Dec;27(6):714-21. doi: 10.1165/rcmb.4746. PMID: 12444031
Abnormal lipid composition of bronchoalveolar lavage fluid obtained from individuals with AIDS-related lung disease.
Rose RM, Catalano PJ, Koziel H, Furlong ST
Am J Respir Crit Care Med 1994 Feb;149(2 Pt 1):332-8. doi: 10.1164/ajrccm.149.2.8306026. PMID: 8306026
Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis.
Ohar JA, Jackson F, Dettenmeier PA, Bedrossian CW, Tricomi SM, Evans RG
Chest 1992 Oct;102(4):999-1004. doi: 10.1378/chest.102.4.999. PMID: 1395816
Idiopathic pulmonary fibrosis. Pretreatment bronchoalveolar lavage cellular constituents and their relationships with lung histopathology and clinical response to therapy.
Watters LC, Schwarz MI, Cherniack RM, Waldron JA, Dunn TL, Stanford RE, King TE
Am Rev Respir Dis 1987 Mar;135(3):696-704. doi: 10.1164/arrd.1987.135.3.696. PMID: 3826895
Fetal lung development in the diabetic pregnancy.
Bourbon JR, Farrell PM
Pediatr Res 1985 Mar;19(3):253-67. doi: 10.1203/00006450-198503000-00001. PMID: 3885150

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