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Neonatal focal clonic seizure

MedGen UID:: 1719809
•Concept ID:: C5397824
•: Disease or Syndrome

HPO:	HP:0032818

Definition

Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is unilateral regularly repeating jerking involving the same muscle groups. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeonatal focal clonic seizure

Seizure
- Neonatal seizure
  - Neonatal seizure with electrographic correlate
    - Neonatal electro-clinical seizure
      - Neonatal electro-clinical motor seizure
        Neonatal electro-clinical clonic seizure
        Neonatal focal clonic seizure

Professional guidelines

PubMed

Genotype-phenotype correlation of CACNA1A variants in children with epilepsy.

Niu X, Yang Y, Chen Y, Cheng M, Liu M, Ding C, Tian X, Yang Z, Jiang Y, Zhang Y
Dev Med Child Neurol 2022 Jan;64(1):105-111. Epub 2021 Jul 15 doi: 10.1111/dmcn.14985. PMID: 34263451

Seizure in HIV-infected patients: clinical presentation, cause and treatment outcome in Ethiopia-a retrospective study.

Amare A
BMC Infect Dis 2021 Aug 10;21(1):790. doi: 10.1186/s12879-021-06497-7. PMID: 34376185 Free PMC Article

Convulsions in children.

Vince JD
P N G Med J 1992 Jun;35(2):144-51. PMID: 1509814

See all (7)

Recent clinical studies

Etiology

Relationship Between Epileptic Activity and Developmental Outcome in KCNQ2-Related Epilepsy.

Casas-Alba D, Aguilar A, Alonso I, García MT, Cilio MR, Fons C; BIO-KCNQ2-Spanish Study Group
Pediatr Neurol 2023 Jul;144:11-15. Epub 2023 Mar 9 doi: 10.1016/j.pediatrneurol.2023.03.004. PMID: 37099824

EEG and clinical characteristics of neonatal parechovirus encephalitis.

Sirsi D, Lowden A, Dolce A, Machie M, Thomas J, Joshi C
Epilepsy Res 2023 May;192:107143. Epub 2023 Apr 17 doi: 10.1016/j.eplepsyres.2023.107143. PMID: 37084674

Genotype-phenotype correlation of CACNA1A variants in children with epilepsy.

Niu X, Yang Y, Chen Y, Cheng M, Liu M, Ding C, Tian X, Yang Z, Jiang Y, Zhang Y
Dev Med Child Neurol 2022 Jan;64(1):105-111. Epub 2021 Jul 15 doi: 10.1111/dmcn.14985. PMID: 34263451

The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.

Pressler RM, Cilio MR, Mizrahi EM, Moshé SL, Nunes ML, Plouin P, Vanhatalo S, Yozawitz E, de Vries LS, Puthenveettil Vinayan K, Triki CC, Wilmshurst JM, Yamamoto H, Zuberi SM
Epilepsia 2021 Mar;62(3):615-628. Epub 2021 Feb 1 doi: 10.1111/epi.16815. PMID: 33522601

Evaluation of the Neonate with Seizures.

Martin M, Querubin J, Hagen E, Lim J
Pediatr Ann 2020 Jul 1;49(7):e292-e298. doi: 10.3928/19382359-20200623-01. PMID: 32674166

See all (71)

Diagnosis

Neonatal Seizures-Perspective in Low-and Middle-Income Countries.

Vegda H, Krishnan V, Variane G, Bagayi V, Ivain P, Pressler RM
Indian J Pediatr 2022 Mar;89(3):245-253. Epub 2022 Jan 20 doi: 10.1007/s12098-021-04039-2. PMID: 35050459 Free PMC Article

The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.

Evaluation of the Neonate with Seizures.

Martin M, Querubin J, Hagen E, Lim J
Pediatr Ann 2020 Jul 1;49(7):e292-e298. doi: 10.3928/19382359-20200623-01. PMID: 32674166

Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis.

D'Antonio F, Pagani G, Familiari A, Khalil A, Sagies TL, Malinger G, Leibovitz Z, Garel C, Moutard ML, Pilu G, Bhide A, Acharya G, Leombroni M, Manzoli L, Papageorghiou A, Prefumo F
Pediatrics 2016 Sep;138(3) doi: 10.1542/peds.2016-0445. PMID: 27581855

Monitoring neonatal seizures.

Boylan GB, Stevenson NJ, Vanhatalo S
Semin Fetal Neonatal Med 2013 Aug;18(4):202-8. Epub 2013 May 24 doi: 10.1016/j.siny.2013.04.004. PMID: 23707519

See all (81)

Therapy

Adult phenotype of KCNQ2 encephalopathy.

Boets S, Johannesen KM, Destree A, Manti F, Ramantani G, Lesca G, Vercueil L, Koenig MK, Striano P, Møller RS, Cooper E, Weckhuysen S
J Med Genet 2022 Jun;59(6):528-535. Epub 2021 Apr 2 doi: 10.1136/jmedgenet-2020-107449. PMID: 33811133

Lacosamide in status epilepticus: Systematic review of current evidence.

Strzelczyk A, Zöllner JP, Willems LM, Jost J, Paule E, Schubert-Bast S, Rosenow F, Bauer S
Epilepsia 2017 Jun;58(6):933-950. Epub 2017 Mar 11 doi: 10.1111/epi.13716. PMID: 28295226

Monitoring neonatal seizures.

Boylan GB, Stevenson NJ, Vanhatalo S
Semin Fetal Neonatal Med 2013 Aug;18(4):202-8. Epub 2013 May 24 doi: 10.1016/j.siny.2013.04.004. PMID: 23707519

Midline spikes.

Yong T, Chayasirisobhon S, Yoshina JS, Tin SN, Tehrani K, Skinner SE, Markus E, Spurgeon BD, Gurbani S
Clin EEG Neurosci 2008 Jan;39(1):28-32. doi: 10.1177/155005940803900110. PMID: 18318416

Convulsions in children.

Vince JD
P N G Med J 1992 Jun;35(2):144-51. PMID: 1509814

See all (43)

Prognosis

Epilepsy syndromes in cerebral palsy: varied, evolving and mostly self-limited.

Cooper MS, Mackay MT, Dagia C, Fahey MC, Howell KB, Reddihough D, Reid S, Harvey AS
Brain 2023 Feb 13;146(2):587-599. doi: 10.1093/brain/awac274. PMID: 35871494

Adult phenotype of KCNQ2 encephalopathy.

Seizure in HIV-infected patients: clinical presentation, cause and treatment outcome in Ethiopia-a retrospective study.

Amare A
BMC Infect Dis 2021 Aug 10;21(1):790. doi: 10.1186/s12879-021-06497-7. PMID: 34376185 Free PMC Article

Neonatal seizures.

Plouin P, Kaminska A
Handb Clin Neurol 2013;111:467-76. doi: 10.1016/B978-0-444-52891-9.00051-8. PMID: 23622196

Benign childhood focal epilepsies: assessment of established and newly recognized syndromes.

Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M
Brain 2008 Sep;131(Pt 9):2264-86. Epub 2008 Aug 21 doi: 10.1093/brain/awn162. PMID: 18718967

See all (45)

Clinical prediction guides

Relationship Between Epileptic Activity and Developmental Outcome in KCNQ2-Related Epilepsy.

Genotype-phenotype correlation of CACNA1A variants in children with epilepsy.

Niu X, Yang Y, Chen Y, Cheng M, Liu M, Ding C, Tian X, Yang Z, Jiang Y, Zhang Y
Dev Med Child Neurol 2022 Jan;64(1):105-111. Epub 2021 Jul 15 doi: 10.1111/dmcn.14985. PMID: 34263451

Seizure in HIV-infected patients: clinical presentation, cause and treatment outcome in Ethiopia-a retrospective study.

Amare A
BMC Infect Dis 2021 Aug 10;21(1):790. doi: 10.1186/s12879-021-06497-7. PMID: 34376185 Free PMC Article

Neonatal seizures: When semiology points to etiology.

Santarone ME, Pietrafusa N, Fusco L
Seizure 2020 Aug;80:161-165. Epub 2020 Jun 18 doi: 10.1016/j.seizure.2020.06.025. PMID: 32585613

Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis.

See all (42)

Recent systematic reviews

Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.

Pack AM, Oskoui M, Williams Roberson S, Donley DK, French J, Gerard EE, Gloss D, Miller WR, Munger Clary HM, Osmundson SS, McFadden B, Parratt K, Pennell PB, Saade G, Smith DB, Sullivan K, Thomas SV, Tomson T, Dolan O'Brien M, Botchway-Doe K, Silsbee HM, Keezer MR
Neurology 2024 Jun;102(11):e209279. Epub 2024 May 15 doi: 10.1212/WNL.0000000000209279. PMID: 38748979

Lacosamide in status epilepticus: Systematic review of current evidence.

Strzelczyk A, Zöllner JP, Willems LM, Jost J, Paule E, Schubert-Bast S, Rosenow F, Bauer S
Epilepsia 2017 Jun;58(6):933-950. Epub 2017 Mar 11 doi: 10.1111/epi.13716. PMID: 28295226

See all (2)

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Neonatal focal clonic seizure

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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