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Liver Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
1721001
Concept ID:
C5419810
Neoplastic Process
Synonym: Liver MANEC

Definition

A carcinoma that arises from the liver and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Recent clinical studies

Etiology

Zheng H, Zhao Y, He Q, Hao H, Tian Y, Zou B, Jiang L, Qiu X, Zhou Y, Li Z, Xu Y, Zhao G, Xue F, Li S, Fu W, Li Y, Zhou X, Li Y, Zhu Z, Chen J, Xu Z, Cai L, Li E, Li H, Xie J, Zheng C, Lu J, Li P, Huang C
Gastric Cancer 2021 Mar;24(2):503-514. Epub 2020 Sep 11 doi: 10.1007/s10120-020-01119-8. PMID: 32915373
Shiihara M, Higuchi R, Furukawa T, Yazawa T, Uemura S, Izumo W, Yamamoto M
Dig Surg 2021;38(1):30-37. Epub 2020 Jun 22 doi: 10.1159/000508443. PMID: 32570243
Tian F, Dai MH, Jia CW, Liu ZW, Li BL
BMC Surg 2019 Jul 11;19(1):89. doi: 10.1186/s12893-019-0546-0. PMID: 31296197Free PMC Article
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508

Diagnosis

Clement D, Brown S, Leerdam MV, Tesselaar M, Ramage J, Srirajaskanthan R
Curr Oncol Rep 2024 Feb;26(2):121-128. Epub 2024 Jan 25 doi: 10.1007/s11912-024-01494-w. PMID: 38270848
Costa AC, Cavalcanti CLC, Coelho HGB, Leão LHA, Soares DTC, Santa-Cruz F, Paz AR, Ferraz ÁAB
Am J Case Rep 2021 May 4;22:e929511. doi: 10.12659/AJCR.929511. PMID: 33945521Free PMC Article
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Lin YX, Jia QB, Fu YY, Cheng NS
J Gastrointest Surg 2018 Aug;22(8):1452-1454. Epub 2018 Jan 8 doi: 10.1007/s11605-017-3664-y. PMID: 29313288
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Therapy

Lin Z, Chen J, Guo Y
Medicine (Baltimore) 2019 Jun;98(23):e16000. doi: 10.1097/MD.0000000000016000. PMID: 31169743Free PMC Article
Kaneko Y, Saito S, Takahashi K, Kanamaru R, Hosoya Y, Yamaguchi H, Kitayama J, Niki T, Lefor AK, Sata N
Clin J Gastroenterol 2019 Dec;12(6):534-538. Epub 2019 May 27 doi: 10.1007/s12328-019-00995-7. PMID: 31134449
Semrau S, Agaimy A, Pavel M, Lubgan D, Schmidt D, Cavallaro A, Golcher H, Grützmann R, Fietkau R
J Med Case Rep 2019 Mar 23;13(1):82. doi: 10.1186/s13256-019-1995-x. PMID: 30902067Free PMC Article
Kaji K, Seishima J, Yamato M, Miyazawa M, Komura T, Marukawa Y, Ohta H, Kasashima S, Kawashima A, Yano M, Unoura M
Clin J Gastroenterol 2016 Feb;9(1):43-8. Epub 2016 Feb 5 doi: 10.1007/s12328-016-0625-z. PMID: 26848585
Song W, Chen W, Zhang S, Peng J, He Y
Diagn Pathol 2012 Nov 27;7:163. doi: 10.1186/1746-1596-7-163. PMID: 23186166Free PMC Article

Prognosis

Liu S, Zhong Z, Xiao M, Song Y, Zhu Y, Hu B, Sun Z, Yi W, Peng C
BMC Gastroenterol 2020 Nov 25;20(1):399. doi: 10.1186/s12876-020-01550-2. PMID: 33238879Free PMC Article
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Tian F, Dai MH, Jia CW, Liu ZW, Li BL
BMC Surg 2019 Jul 11;19(1):89. doi: 10.1186/s12893-019-0546-0. PMID: 31296197Free PMC Article
Brathwaite SA, Smith SM, Wai L, Frankel W, Hays J, Yearsley MM, Abdel-Misih S
Hum Pathol 2018 Mar;73:184-191. Epub 2017 Dec 27 doi: 10.1016/j.humpath.2017.12.009. PMID: 29288693
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Clinical prediction guides

Zheng H, Zhao Y, He Q, Hao H, Tian Y, Zou B, Jiang L, Qiu X, Zhou Y, Li Z, Xu Y, Zhao G, Xue F, Li S, Fu W, Li Y, Zhou X, Li Y, Zhu Z, Chen J, Xu Z, Cai L, Li E, Li H, Xie J, Zheng C, Lu J, Li P, Huang C
Gastric Cancer 2021 Mar;24(2):503-514. Epub 2020 Sep 11 doi: 10.1007/s10120-020-01119-8. PMID: 32915373
Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131
Lin YX, Jia QB, Fu YY, Cheng NS
J Gastrointest Surg 2018 Aug;22(8):1452-1454. Epub 2018 Jan 8 doi: 10.1007/s11605-017-3664-y. PMID: 29313288
Kaji K, Seishima J, Yamato M, Miyazawa M, Komura T, Marukawa Y, Ohta H, Kasashima S, Kawashima A, Yano M, Unoura M
Clin J Gastroenterol 2016 Feb;9(1):43-8. Epub 2016 Feb 5 doi: 10.1007/s12328-016-0625-z. PMID: 26848585
Zhang W, Xiao W, Ma H, Sun M, Chen H, Zheng S
Int J Clin Exp Pathol 2014;7(9):6333-8. Epub 2014 Aug 15 PMID: 25337287Free PMC Article

Recent systematic reviews

Sluiter NR, van der Bilt JD, Croll DMR, Vriens MR, de Hingh IHJT, Hemmer P, Aalbers AGJ, Bremers AJA, Ceelen W, D'Hoore A, Schoonmade LJ, Coupé V, Verheul H, Kazemier G, Tuynman JB; Dutch Peritoneal Oncology Group
Clin Colorectal Cancer 2020 Sep;19(3):e87-e99. Epub 2020 Jan 30 doi: 10.1016/j.clcc.2020.01.002. PMID: 32651131

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