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Resectable Pancreatic Adenosquamous Carcinoma

MedGen UID:
1722610
•Concept ID:
C5420857
•
Neoplastic Process

Definition

Pancreatic adenosquamous carcinoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Pancreatic Adenosquamous Carcinoma

Professional guidelines

PubMed

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
The importance of multimodal therapy in the management of nonmetastatic adenosquamous carcinoma of the pancreas: Analysis of treatment sequence and strategy.
Hue JJ, Katayama E, Sugumar K, Winter JM, Ammori JB, Rothermel LD, Hardacre JM, Ocuin LM
Surgery 2021 May;169(5):1102-1109. Epub 2020 Dec 26 doi: 10.1016/j.surg.2020.11.026. PMID: 33376004

Recent clinical studies

Etiology

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
PD-L1 expression and surgical outcomes of adenosquamous carcinoma of the pancreas in a single-centre study of 56 lesions.
Lee SM, Sung CO
Pancreatology 2021 Aug;21(5):920-927. Epub 2021 Mar 17 doi: 10.1016/j.pan.2021.03.004. PMID: 33773917
(18)F-FDG PET/CT feature of pancreatic adenosquamous carcinoma with pathological correlation.
Su W, Zhao S, Chen Y, Zuo C, Cui B, Wang M, Ren F
Abdom Radiol (NY) 2020 Mar;45(3):743-749. doi: 10.1007/s00261-019-02393-6. PMID: 31907569
Clinicopathological features of adenosquamous pancreatic cancer.
Regi P, Butturini G, Malleo G, Pedica F, D'Onofrio M, Bassi C
Langenbecks Arch Surg 2011 Feb;396(2):217-22. Epub 2010 Jul 9 doi: 10.1007/s00423-010-0677-3. PMID: 20617336
Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity.
Trikudanathan G, Dasanu CA
South Med J 2010 Sep;103(9):903-10. doi: 10.1097/SMJ.0b013e3181ebadbd. PMID: 20697320

Diagnosis

Adenosquamous carcinoma of the pancreas: two case reports and review of the literature.
Paramythiotis D, Kyriakidis F, Karlafti E, Didangelos T, Oikonomou IM, Karakatsanis A, Poulios C, Chamalidou E, Vagionas A, Michalopoulos A
J Med Case Rep 2022 Oct 30;16(1):395. doi: 10.1186/s13256-022-03610-5. PMID: 36309754Free PMC Article
Clinical and Histological Basis of Adenosquamous Carcinoma of the Pancreas: A 30-year Experience.
Moslim MA, Lefton MD, Ross EA, Mackrides N, Reddy SS
J Surg Res 2021 Mar;259:350-356. Epub 2020 Nov 13 doi: 10.1016/j.jss.2020.09.024. PMID: 33190924Free PMC Article
Pancreatic Ductal Adenocarcinoma.
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Metastatic pancreatic adenosquamous carcinoma to the scalp: A case report and review of the literature.
Salari B, Sheinbein DM, Rosman IS, Dehner LP
J Cutan Pathol 2020 Mar;47(3):263-268. Epub 2019 Nov 12 doi: 10.1111/cup.13582. PMID: 31587324
Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity.
Trikudanathan G, Dasanu CA
South Med J 2010 Sep;103(9):903-10. doi: 10.1097/SMJ.0b013e3181ebadbd. PMID: 20697320

Therapy

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
NEXUS trial: a multicenter phase II clinical study evaluating the efficacy and safety of the perioperative use of encorafenib, binimetinib, and cetuximab in patients with previously untreated surgically resectable BRAF V600E mutant colorectal oligometastases.
Kobayashi S, Bando H, Taketomi A, Takamoto T, Shinozaki E, Shiozawa M, Hara H, Yamazaki K, Komori K, Matsuhashi N, Kato T, Kagawa Y, Yokota M, Oki E, Komine K, Takahashi S, Wakabayashi M, Yoshino T
BMC Cancer 2023 Aug 21;23(1):779. doi: 10.1186/s12885-023-11311-5. PMID: 37605122Free PMC Article
Partial response in non-resectable adenosquamous carcinoma of the pancreas with high tumour mutation burden treated with gemcitabine, nab-paclitaxel and pembrolizumab.
Paredes de la Fuente R, Doolin JW, Peters ML
BMJ Case Rep 2023 Feb 6;16(2) doi: 10.1136/bcr-2022-251936. PMID: 36746516Free PMC Article
Clinical and Histological Basis of Adenosquamous Carcinoma of the Pancreas: A 30-year Experience.
Moslim MA, Lefton MD, Ross EA, Mackrides N, Reddy SS
J Surg Res 2021 Mar;259:350-356. Epub 2020 Nov 13 doi: 10.1016/j.jss.2020.09.024. PMID: 33190924Free PMC Article
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report.
Connell CM, Brais R, Whitaker H, Upponi S, Beh I, Risdall J, Corrie P, Janowitz T, Jodrell DI
BMC Cancer 2020 Jan 15;20(1):38. doi: 10.1186/s12885-020-6516-1. PMID: 31941506Free PMC Article

Prognosis

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Clinical presentation and prognosis of adenosquamous carcinoma of the pancreas - Matched-pair analysis with pancreatic ductal adenocarcinoma.
Kaiser J, Hinz U, Mayer P, Hank T, Niesen W, Hackert T, Gaida MM, Büchler MW, Strobel O
Eur J Surg Oncol 2021 Jul;47(7):1734-1741. Epub 2021 Feb 16 doi: 10.1016/j.ejso.2021.02.011. PMID: 33622577
Clinical and Histological Basis of Adenosquamous Carcinoma of the Pancreas: A 30-year Experience.
Moslim MA, Lefton MD, Ross EA, Mackrides N, Reddy SS
J Surg Res 2021 Mar;259:350-356. Epub 2020 Nov 13 doi: 10.1016/j.jss.2020.09.024. PMID: 33190924Free PMC Article
Sarcomatous Component in Pancreatic Adenosquamous Carcinoma: A Clinicopathological Series of 7 Cases.
Taniwaki S, Hisaka T, Sakai H, Goto Y, Nomura Y, Kawahara R, Ishikawa H, Yasunaga M, Naito Y, Akiba J, Yano H, Tanaka H, Akagi Y, Okuda K
Anticancer Res 2019 Aug;39(8):4575-4580. doi: 10.21873/anticanres.13636. PMID: 31366562
Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients.
Voong KR, Davison J, Pawlik TM, Uy MO, Hsu CC, Winter J, Hruban RH, Laheru D, Rudra S, Swartz MJ, Nathan H, Edil BH, Schulick R, Cameron JL, Wolfgang CL, Herman JM
Hum Pathol 2010 Jan;41(1):113-22. Epub 2009 Oct 3 doi: 10.1016/j.humpath.2009.07.012. PMID: 19801164Free PMC Article

Clinical prediction guides

PD-L1 expression and surgical outcomes of adenosquamous carcinoma of the pancreas in a single-centre study of 56 lesions.
Lee SM, Sung CO
Pancreatology 2021 Aug;21(5):920-927. Epub 2021 Mar 17 doi: 10.1016/j.pan.2021.03.004. PMID: 33773917
Clinical presentation and prognosis of adenosquamous carcinoma of the pancreas - Matched-pair analysis with pancreatic ductal adenocarcinoma.
Kaiser J, Hinz U, Mayer P, Hank T, Niesen W, Hackert T, Gaida MM, Büchler MW, Strobel O
Eur J Surg Oncol 2021 Jul;47(7):1734-1741. Epub 2021 Feb 16 doi: 10.1016/j.ejso.2021.02.011. PMID: 33622577
Clinical and Histological Basis of Adenosquamous Carcinoma of the Pancreas: A 30-year Experience.
Moslim MA, Lefton MD, Ross EA, Mackrides N, Reddy SS
J Surg Res 2021 Mar;259:350-356. Epub 2020 Nov 13 doi: 10.1016/j.jss.2020.09.024. PMID: 33190924Free PMC Article
(18)F-FDG PET/CT feature of pancreatic adenosquamous carcinoma with pathological correlation.
Su W, Zhao S, Chen Y, Zuo C, Cui B, Wang M, Ren F
Abdom Radiol (NY) 2020 Mar;45(3):743-749. doi: 10.1007/s00261-019-02393-6. PMID: 31907569
PD-L1 expression in pancreatic adenosquamous carcinoma: PD-L1 expression is limited to the squamous component.
Tanigawa M, Naito Y, Akiba J, Kawahara A, Okabe Y, Ishida Y, Ishikawa H, Hisaka T, Fujita F, Yasunaga M, Shigaki T, Sudo T, Mihara Y, Nakayama M, Kondo R, Kusano H, Shimamatsu K, Okuda K, Akagi Y, Yano H
Pathol Res Pract 2018 Dec;214(12):2069-2074. Epub 2018 Oct 19 doi: 10.1016/j.prp.2018.10.006. PMID: 30477643

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