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Metastatic Distal Esophagus Adenocarcinoma

MedGen UID:
1724679
•Concept ID:
C5421257
•
Neoplastic Process

Definition

Distal esophagus adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Distal Esophagus Adenocarcinoma

Professional guidelines

PubMed

Long-Term Postsurgical Outcomes of Neoadjuvant Chemoradiation (CROSS) Versus Chemotherapy (FLOT) for Multimodal Treatment of Adenocarcinoma of the Esophagus and the Esophagogastric Junction.
Gebauer F, Plum PS, Damanakis A, Chon SH, Popp F, Zander T, Quaas A, Fuchs H, Schmidt T, Schröder W, Bruns CJ
Ann Surg Oncol 2023 Nov;30(12):7422-7433. Epub 2023 May 21 doi: 10.1245/s10434-023-13643-9. PMID: 37210683Free PMC Article
Diagnosis and treatment of non-metastatic esophagogastric junction adenocarcinoma: what are the current options?
Gronnier C, Piessen G, Mariette C
J Visc Surg 2012 Feb;149(1):e23-33. Epub 2012 Feb 16 doi: 10.1016/j.jviscsurg.2012.01.003. PMID: 22341763
Management of Barrett's esophagus with and without dysplasia.
Triadafilopoulos G
Scand J Gastroenterol Suppl 2003;(237):40-6. doi: 10.1080/00855910310001494. PMID: 12797681

Recent clinical studies

Etiology

Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma.
Tsai C, Nguyen B, Luthra A, Chou JF, Feder L, Tang LH, Strong VE, Molena D, Jones DR, Coit DG, Ilson DH, Ku GY, Cowzer D, Cadley J, Capanu M, Schultz N, Beal K, Moss NS, Janjigian YY, Maron SB
JAMA Netw Open 2022 Aug 1;5(8):e2228083. doi: 10.1001/jamanetworkopen.2022.28083. PMID: 36001319Free PMC Article
Epidemiology and prevention of oesophageal adenocarcinoma.
Ness-Jensen E
Scand J Gastroenterol 2022 Aug;57(8):891-895. Epub 2022 Mar 2 doi: 10.1080/00365521.2022.2042594. PMID: 35234549
CROSS or FLOT in Distal Esophageal and Gastroesophageal Cancer.
Karadag I, Karakaya S, Ates O, Cakmak Oksuzoglu OB
J Coll Physicians Surg Pak 2021 Mar;31(3):326-329. doi: 10.29271/jcpsp.2021.03.326. PMID: 33775025
Risk factors for Barrett's esophagus: a scoping review.
Ireland CJ, Thompson SK, Laws TA, Esterman A
Cancer Causes Control 2016 Mar;27(3):301-23. Epub 2016 Feb 5 doi: 10.1007/s10552-015-0710-5. PMID: 26847374
Diagnosis and treatment of non-metastatic esophagogastric junction adenocarcinoma: what are the current options?
Gronnier C, Piessen G, Mariette C
J Visc Surg 2012 Feb;149(1):e23-33. Epub 2012 Feb 16 doi: 10.1016/j.jviscsurg.2012.01.003. PMID: 22341763

Diagnosis

Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma.
Tsai C, Nguyen B, Luthra A, Chou JF, Feder L, Tang LH, Strong VE, Molena D, Jones DR, Coit DG, Ilson DH, Ku GY, Cowzer D, Cadley J, Capanu M, Schultz N, Beal K, Moss NS, Janjigian YY, Maron SB
JAMA Netw Open 2022 Aug 1;5(8):e2228083. doi: 10.1001/jamanetworkopen.2022.28083. PMID: 36001319Free PMC Article
CROSS or FLOT in Distal Esophageal and Gastroesophageal Cancer.
Karadag I, Karakaya S, Ates O, Cakmak Oksuzoglu OB
J Coll Physicians Surg Pak 2021 Mar;31(3):326-329. doi: 10.29271/jcpsp.2021.03.326. PMID: 33775025
Risk factors for Barrett's esophagus: a scoping review.
Ireland CJ, Thompson SK, Laws TA, Esterman A
Cancer Causes Control 2016 Mar;27(3):301-23. Epub 2016 Feb 5 doi: 10.1007/s10552-015-0710-5. PMID: 26847374
Diagnosis and treatment of non-metastatic esophagogastric junction adenocarcinoma: what are the current options?
Gronnier C, Piessen G, Mariette C
J Visc Surg 2012 Feb;149(1):e23-33. Epub 2012 Feb 16 doi: 10.1016/j.jviscsurg.2012.01.003. PMID: 22341763
Radical chemoradiotherapy for adenocarcinoma of the distal oesophagus and oesophagogastric junction: what planning margins should we use?
Whitfield GA, Jackson A, Moore C, Price P
Br J Radiol 2008 Dec;81(972):921-34. Epub 2008 Sep 15 doi: 10.1259/bjr/23903754. PMID: 18794193

Therapy

Preferred neoadjuvant therapy for gastric and gastroesophageal junction adenocarcinoma: a systematic review and network meta-analysis.
Grizzi G, Petrelli F, Di Bartolomeo M, Viti M, Texeira Moraes M, Luciani A, Passalacqua R, Ghidini M, Tomasello G, Baiocchi GL, Celotti A
Gastric Cancer 2022 Sep;25(5):982-987. Epub 2022 Jun 15 doi: 10.1007/s10120-022-01314-9. PMID: 35704113
Epidemiology and prevention of oesophageal adenocarcinoma.
Ness-Jensen E
Scand J Gastroenterol 2022 Aug;57(8):891-895. Epub 2022 Mar 2 doi: 10.1080/00365521.2022.2042594. PMID: 35234549
Update on Gastroesophageal Adenocarcinoma Targeted Therapies.
Maron SB, Catenacci DVT
Hematol Oncol Clin North Am 2017 Jun;31(3):511-527. doi: 10.1016/j.hoc.2017.01.009. PMID: 28501091Free PMC Article
Risk factors for Barrett's esophagus: a scoping review.
Ireland CJ, Thompson SK, Laws TA, Esterman A
Cancer Causes Control 2016 Mar;27(3):301-23. Epub 2016 Feb 5 doi: 10.1007/s10552-015-0710-5. PMID: 26847374
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma.
Tsai C, Nguyen B, Luthra A, Chou JF, Feder L, Tang LH, Strong VE, Molena D, Jones DR, Coit DG, Ilson DH, Ku GY, Cowzer D, Cadley J, Capanu M, Schultz N, Beal K, Moss NS, Janjigian YY, Maron SB
JAMA Netw Open 2022 Aug 1;5(8):e2228083. doi: 10.1001/jamanetworkopen.2022.28083. PMID: 36001319Free PMC Article
Update on Gastroesophageal Adenocarcinoma Targeted Therapies.
Maron SB, Catenacci DVT
Hematol Oncol Clin North Am 2017 Jun;31(3):511-527. doi: 10.1016/j.hoc.2017.01.009. PMID: 28501091Free PMC Article
Novel Targeted Therapies for Esophagogastric Cancer.
Maron SB, Catenacci DV
Surg Oncol Clin N Am 2017 Apr;26(2):293-312. doi: 10.1016/j.soc.2016.10.002. PMID: 28279470Free PMC Article
Risk factors for Barrett's esophagus: a scoping review.
Ireland CJ, Thompson SK, Laws TA, Esterman A
Cancer Causes Control 2016 Mar;27(3):301-23. Epub 2016 Feb 5 doi: 10.1007/s10552-015-0710-5. PMID: 26847374
Diagnosis and treatment of non-metastatic esophagogastric junction adenocarcinoma: what are the current options?
Gronnier C, Piessen G, Mariette C
J Visc Surg 2012 Feb;149(1):e23-33. Epub 2012 Feb 16 doi: 10.1016/j.jviscsurg.2012.01.003. PMID: 22341763

Clinical prediction guides

A phase II study of perioperative pembrolizumab plus mFOLFOX in patients with potentially resectable esophagus, gastroesophageal junction (GEJ), and stomach adenocarcinoma.
Sun W, Veeramachaneni N, Al-Rajabi R, Madan R, Kasi A, Al-Kasspooles M, Baranda J, Saeed A, Phadnis MA, Godwin AK, Olyaee M, Streeter N, Nagji A, Dai J, Williamson S
Cancer Med 2023 Aug;12(15):16098-16107. Epub 2023 Jun 16 doi: 10.1002/cam4.6263. PMID: 37326317Free PMC Article
Facing adenocarcinoma of distal esophagus and esophagogastric junction: a CROSS versus FLOT propensity score-matched analysis of oncological outcomes in a high-volume institution.
Lombardi PM, Pansa A, Basato S, Giorgi L, Perano V, Marano S, Castoro C
Updates Surg 2023 Jun;75(4):921-930. Epub 2023 Mar 29 doi: 10.1007/s13304-023-01497-5. PMID: 36991302
Risk factors for Barrett's esophagus: a scoping review.
Ireland CJ, Thompson SK, Laws TA, Esterman A
Cancer Causes Control 2016 Mar;27(3):301-23. Epub 2016 Feb 5 doi: 10.1007/s10552-015-0710-5. PMID: 26847374
The molecular biology of esophageal adenocarcinoma.
Koppert LB, Wijnhoven BP, van Dekken H, Tilanus HW, Dinjens WN
J Surg Oncol 2005 Dec 1;92(3):169-90. doi: 10.1002/jso.20359. PMID: 16299787
Pattern of lymphatic spread of Barrett's cancer.
Feith M, Stein HJ, Siewert JR
World J Surg 2003 Sep;27(9):1052-7. Epub 2003 Aug 18 doi: 10.1007/s00268-003-7060-2. PMID: 12917758

Recent systematic reviews

Preferred neoadjuvant therapy for gastric and gastroesophageal junction adenocarcinoma: a systematic review and network meta-analysis.
Grizzi G, Petrelli F, Di Bartolomeo M, Viti M, Texeira Moraes M, Luciani A, Passalacqua R, Ghidini M, Tomasello G, Baiocchi GL, Celotti A
Gastric Cancer 2022 Sep;25(5):982-987. Epub 2022 Jun 15 doi: 10.1007/s10120-022-01314-9. PMID: 35704113
The Value of Paratracheal Lymphadenectomy in Esophagectomy for Adenocarcinoma of the Esophagus or Gastroesophageal Junction: A Systematic Review of the Literature.
Gantxegi A, Kingma BF, Ruurda JP, Nieuwenhuijzen GAP, Luyer MDP, van Hillegersberg R
Ann Surg Oncol 2022 Feb;29(2):1347-1356. Epub 2021 Nov 29 doi: 10.1245/s10434-021-10810-8. PMID: 34845567Free PMC Article
Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article

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