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Colorectal Adenoma-Like Adenocarcinoma

MedGen UID:
1724785
•Concept ID:
C5419799
•
Neoplastic Process
Synonym: Colorectal Villous Adenocarcinoma

Definition

A well differentiated colorectal adenocarcinoma with good prognosis. It resembles a villous adenoma on the surface. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Adenoma-Like Adenocarcinoma

Professional guidelines

PubMed

Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.
Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518

Recent clinical studies

Etiology

Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.
Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518
Adenoma-like adenocarcinoma: clinicopathologic characterization of a newly recognized subtype of colorectal carcinoma.
González IA, Bauer PS, Liu J, Chatterjee D
Hum Pathol 2021 Jan;107:9-19. Epub 2020 Sep 28 doi: 10.1016/j.humpath.2020.09.008. PMID: 32991929Free PMC Article
Cancer risk after resection of polypoid dysplasia in patients with longstanding ulcerative colitis: a meta-analysis.
Wanders LK, Dekker E, Pullens B, Bassett P, Travis SP, East JE
Clin Gastroenterol Hepatol 2014 May;12(5):756-64. Epub 2013 Aug 3 doi: 10.1016/j.cgh.2013.07.024. PMID: 23920032
Diagnostic standards in the pathology of inflammatory bowel disease.
Loddenkemper C
Dig Dis 2009;27(4):576-83. Epub 2009 Nov 4 doi: 10.1159/000233301. PMID: 19897978
Evaluation of polypoid lesions in inflammatory bowel disease.
Chawla A, Judge TA, Lichtenstein GR
Gastrointest Endosc Clin N Am 2002 Jul;12(3):525-34, ix. doi: 10.1016/s1052-5157(02)00018-1. PMID: 12486942

Diagnosis

Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.
Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518
Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation.
Gonzalez RS, Cates JM, Washington MK, Beauchamp RD, Coffey RJ, Shi C
Histopathology 2016 Jan;68(2):183-90. Epub 2015 Jun 4 doi: 10.1111/his.12725. PMID: 25913616Free PMC Article
Diagnostic standards in the pathology of inflammatory bowel disease.
Loddenkemper C
Dig Dis 2009;27(4):576-83. Epub 2009 Nov 4 doi: 10.1159/000233301. PMID: 19897978
Evaluation of polypoid lesions in inflammatory bowel disease.
Chawla A, Judge TA, Lichtenstein GR
Gastrointest Endosc Clin N Am 2002 Jul;12(3):525-34, ix. doi: 10.1016/s1052-5157(02)00018-1. PMID: 12486942

Prognosis

Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.
Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518
Adenoma-like adenocarcinoma: clinicopathologic characterization of a newly recognized subtype of colorectal carcinoma.
González IA, Bauer PS, Liu J, Chatterjee D
Hum Pathol 2021 Jan;107:9-19. Epub 2020 Sep 28 doi: 10.1016/j.humpath.2020.09.008. PMID: 32991929Free PMC Article
Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation.
Gonzalez RS, Cates JM, Washington MK, Beauchamp RD, Coffey RJ, Shi C
Histopathology 2016 Jan;68(2):183-90. Epub 2015 Jun 4 doi: 10.1111/his.12725. PMID: 25913616Free PMC Article

Clinical prediction guides

Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.
Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518

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