U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Primary Peritoneal Serous Adenocarcinoma

MedGen UID:
1726246
•Concept ID:
C5418957
•
Neoplastic Process

Definition

Primary peritoneal serous adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Primary Peritoneal Serous Adenocarcinoma

Professional guidelines

PubMed

BRCA testing in women with high-grade serous ovarian cancer: gynecologic oncologist-initiated testing compared with genetics referral.
Piedimonte S, Power J, Foulkes WD, Weber E, Palma L, Schiavi A, Ambrosio E, Konci R, Gilbert L, Jardon K, Baret L, Zeng X
Int J Gynecol Cancer 2020 Nov;30(11):1757-1761. Epub 2020 Aug 5 doi: 10.1136/ijgc-2020-001261. PMID: 32759180
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Diagnostic and therapeutic management of cancer of an unknown primary.
Pavlidis N, Briasoulis E, Hainsworth J, Greco FA
Eur J Cancer 2003 Sep;39(14):1990-2005. doi: 10.1016/s0959-8049(03)00547-1. PMID: 12957453

Recent clinical studies

Etiology

Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
Biomarkers expression among paired serous ovarian cancer primary lesions and their peritoneal cavity metastases in treatment-naïve patients: A single-center study.
Nikas IP, Lee C, Song MJ, Kim B, Ryu HS
Cancer Med 2022 Jun;11(11):2193-2203. Epub 2022 Feb 25 doi: 10.1002/cam4.4600. PMID: 35212471Free PMC Article
Mucinous, endometrioid, and serous ovarian cancers with peritoneal dissemination are potent candidates for P-cadherin targeted therapy: a retrospective cohort study.
Kayahashi K, Mizumoto Y, Matsuoka A, Obata T, Iwadare J, Nakamura M, Daikoku T, Fujiwara H
BMC Cancer 2021 Jan 7;21(1):32. doi: 10.1186/s12885-020-07737-w. PMID: 33413178Free PMC Article
Targeting progesterone signaling prevents metastatic ovarian cancer.
Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC Jr, Godwin AK, Miller KD, Cho CH, Kim J
Proc Natl Acad Sci U S A 2020 Dec 15;117(50):31993-32004. Epub 2020 Dec 1 doi: 10.1073/pnas.2013595117. PMID: 33262282Free PMC Article
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116

Diagnosis

Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology.
Brown Y, Hua S, Tanwar PS
Matrix Biol 2023 Apr;118:16-46. Epub 2023 Feb 11 doi: 10.1016/j.matbio.2023.02.004. PMID: 36781087
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268
Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas.
Ordóñez NG
Am J Surg Pathol 1998 Oct;22(10):1203-14. doi: 10.1097/00000478-199810000-00005. PMID: 9777982

Therapy

Targeting progesterone signaling prevents metastatic ovarian cancer.
Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Fernández FM, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC Jr, Godwin AK, Miller KD, Cho CH, Kim J
Proc Natl Acad Sci U S A 2020 Dec 15;117(50):31993-32004. Epub 2020 Dec 1 doi: 10.1073/pnas.2013595117. PMID: 33262282Free PMC Article
In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.
Kim O, Park EY, Klinkebiel DL, Pack SD, Shin YH, Abdullaev Z, Emerson RE, Coffey DM, Kwon SY, Creighton CJ, Kwon S, Chang EC, Chiang T, Yatsenko AN, Chien J, Cheon DJ, Yang-Hartwich Y, Nakshatri H, Nephew KP, Behringer RR, Fernández FM, Cho CH, Vanderhyden B, Drapkin R, Bast RC Jr, Miller KD, Karpf AR, Kim J
PLoS Genet 2020 Jun;16(6):e1008808. Epub 2020 Jun 4 doi: 10.1371/journal.pgen.1008808. PMID: 32497036Free PMC Article
Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma.
De Thaye E, Van de Vijver K, Van der Meulen J, Taminau J, Wagemans G, Denys H, Van Dorpe J, Berx G, Ceelen W, Van Bocxlaer J, De Wever O
Sci Rep 2020 Apr 21;10(1):6688. doi: 10.1038/s41598-020-63738-6. PMID: 32317693Free PMC Article
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects.
Altaras MM, Aviram R, Cohen I, Cordoba M, Weiss E, Beyth Y
Gynecol Oncol 1991 Mar;40(3):230-6. doi: 10.1016/0090-8258(90)90283-q. PMID: 2013445

Prognosis

Biomarkers expression among paired serous ovarian cancer primary lesions and their peritoneal cavity metastases in treatment-naïve patients: A single-center study.
Nikas IP, Lee C, Song MJ, Kim B, Ryu HS
Cancer Med 2022 Jun;11(11):2193-2203. Epub 2022 Feb 25 doi: 10.1002/cam4.4600. PMID: 35212471Free PMC Article
Mucinous, endometrioid, and serous ovarian cancers with peritoneal dissemination are potent candidates for P-cadherin targeted therapy: a retrospective cohort study.
Kayahashi K, Mizumoto Y, Matsuoka A, Obata T, Iwadare J, Nakamura M, Daikoku T, Fujiwara H
BMC Cancer 2021 Jan 7;21(1):32. doi: 10.1186/s12885-020-07737-w. PMID: 33413178Free PMC Article
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation.
Ricciardelli C, Lokman NA, Cheruvu S, Tan IA, Ween MP, Pyragius CE, Ruszkiewicz A, Hoffmann P, Oehler MK
Clin Exp Metastasis 2015 Jun;32(5):441-55. Epub 2015 Apr 21 doi: 10.1007/s10585-015-9718-1. PMID: 25895698
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article

Clinical prediction guides

Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
The clinical impact of serous tubal intraepithelial carcinoma on outcomes of patients with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum.
Toptas T, Pestereli E, Simsek T, Bozkurt S, Erdogan G, Karaveli S
J Cancer Res Ther 2018 Apr-Jun;14(3):587-592. doi: 10.4103/0973-1482.172130. PMID: 29893323
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Metachronous serous endometrial intraepithelial carcinoma and serous peritoneal carcinoma: analysis of probable independent lesions.
Furuya M, Sato T, Tanaka R, Yamamoto M, Yokota NR, Miyagi E
Diagn Pathol 2016 Nov 14;11(1):130. doi: 10.1186/s13000-016-0585-0. PMID: 27842566Free PMC Article
Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas.
Ordóñez NG
Am J Surg Pathol 1998 Oct;22(10):1203-14. doi: 10.1097/00000478-199810000-00005. PMID: 9777982

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...