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Advanced Diffuse Large B-Cell Lymphoma

MedGen UID:
1727043
•Concept ID:
C5419059
•
Neoplastic Process

Definition

Diffuse large B-cell lymphoma that has spread extensively to distant anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Consolidation radiotherapy to bulky or semibulky lesions in the management of stage III-IV diffuse large B cell lymphomas.
Ferreri AJ, Dell'Oro S, Reni M, Ceresoli GL, Cozzarini C, Ponzoni M, Villa E
Oncology 2000 Apr;58(3):219-26. doi: 10.1159/000012104. PMID: 10765124

Recent clinical studies

Etiology

Development and validation of a novel prognostic nomogram for advanced diffuse large B cell lymphoma.
Wan M, Zhang W, Huang H, Fang X, Chen Y, Tian Y, Yao Y, Weng H, Chen Z, Yu L, Tian Y, Huang H, Li X, Hong H, Lin T
Clin Exp Med 2024 Mar 30;24(1):64. doi: 10.1007/s10238-024-01326-y. PMID: 38554186Free PMC Article
Statins enhance the chemosensitivity of R-CHOP in diffuse large B-cell lymphoma.
Gouni S, Strati P, Toruner G, Aradhya A, Landgraf R, Bilbao D, Vega F, Agarwal NK
Leuk Lymphoma 2022 Jun;63(6):1302-1313. Epub 2021 Dec 31 doi: 10.1080/10428194.2021.2020782. PMID: 34969327
Consolidation anti-CD22 fractionated radioimmunotherapy with (90)Y-epratuzumab tetraxetan following R-CHOP in elderly patients with diffuse large B-cell lymphoma: a prospective, single group, phase 2 trial.
Kraeber-Bodere F, Pallardy A, Maisonneuve H, Campion L, Moreau A, Soubeyran I, Le Gouill S, Tournilhac O, Daguindau E, Jardel H, Morineau N, Bouabdallah K, Gyan E, Moles MP, Gressin R, Berthou C, Sadot S, Moreau P, Deau B, Bodet-Milin C, Cazeau AL, Garin E, Salaun PY, Vuillez JP, Gouilleux-Gruart V, Barbet J, Wegener WA, Goldenberg DM, Lamy T, Soubeyran P
Lancet Haematol 2017 Jan;4(1):e35-e45. Epub 2016 Dec 8 doi: 10.1016/S2352-3026(16)30168-5. PMID: 27964867
Negative impact of concurrent overexpression of MYC and BCL2 in patients with advanced diffuse large B-cell lymphoma treated with dose-intensified immunochemotherapy.
Takahashi H, Miura K, Nakagawa M, Sugitani M, Amano Y, Kurita D, Sakagami M, Ohtake S, Uchino Y, Kodaira H, Iriyama N, Kobayashi S, Hojo A, Kobayashi Y, Hirabayashi Y, Kusuda M, Hatta Y, Nakayama T, Takei M
Leuk Lymphoma 2016 Dec;57(12):2784-2790. Epub 2016 Apr 13 doi: 10.3109/10428194.2016.1167205. PMID: 27071312
Survival in advanced diffuse large B-cell lymphoma in pre- and post-rituximab Eras in the United States.
Shah BK, Bista A, Shafii B
Anticancer Res 2014 Sep;34(9):5117-20. PMID: 25202101

Diagnosis

Development and validation of a novel prognostic nomogram for advanced diffuse large B cell lymphoma.
Wan M, Zhang W, Huang H, Fang X, Chen Y, Tian Y, Yao Y, Weng H, Chen Z, Yu L, Tian Y, Huang H, Li X, Hong H, Lin T
Clin Exp Med 2024 Mar 30;24(1):64. doi: 10.1007/s10238-024-01326-y. PMID: 38554186Free PMC Article
Statins enhance the chemosensitivity of R-CHOP in diffuse large B-cell lymphoma.
Gouni S, Strati P, Toruner G, Aradhya A, Landgraf R, Bilbao D, Vega F, Agarwal NK
Leuk Lymphoma 2022 Jun;63(6):1302-1313. Epub 2021 Dec 31 doi: 10.1080/10428194.2021.2020782. PMID: 34969327
Obinutuzumab plus CHOP is effective and has a tolerable safety profile in previously untreated, advanced diffuse large B-cell lymphoma: the phase II GATHER study.
Sharman JP, Forero-Torres A, Costa LJ, Flinn IW, Inhorn L, Kelly K, Bessudo A, Fayad LE, Kaminski MS, Evens AM, Flowers CR, Sahin D, Mundt KE, Sandmann T, Fingerle-Rowson G, Vignal C, Mobasher M, Zelenetz AD
Leuk Lymphoma 2019 Apr;60(4):894-903. Epub 2018 Oct 2 doi: 10.1080/10428194.2018.1515940. PMID: 30277102Free PMC Article
Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells.
Wang Y, Zhang WY, Han QW, Liu Y, Dai HR, Guo YL, Bo J, Fan H, Zhang Y, Zhang YJ, Chen MX, Feng KC, Wang QS, Fu XB, Han WD
Clin Immunol 2014 Dec;155(2):160-75. Epub 2014 Oct 16 doi: 10.1016/j.clim.2014.10.002. PMID: 25444722
Survival in advanced diffuse large B-cell lymphoma in pre- and post-rituximab Eras in the United States.
Shah BK, Bista A, Shafii B
Anticancer Res 2014 Sep;34(9):5117-20. PMID: 25202101

Therapy

Statins enhance the chemosensitivity of R-CHOP in diffuse large B-cell lymphoma.
Gouni S, Strati P, Toruner G, Aradhya A, Landgraf R, Bilbao D, Vega F, Agarwal NK
Leuk Lymphoma 2022 Jun;63(6):1302-1313. Epub 2021 Dec 31 doi: 10.1080/10428194.2021.2020782. PMID: 34969327
Obinutuzumab plus CHOP is effective and has a tolerable safety profile in previously untreated, advanced diffuse large B-cell lymphoma: the phase II GATHER study.
Sharman JP, Forero-Torres A, Costa LJ, Flinn IW, Inhorn L, Kelly K, Bessudo A, Fayad LE, Kaminski MS, Evens AM, Flowers CR, Sahin D, Mundt KE, Sandmann T, Fingerle-Rowson G, Vignal C, Mobasher M, Zelenetz AD
Leuk Lymphoma 2019 Apr;60(4):894-903. Epub 2018 Oct 2 doi: 10.1080/10428194.2018.1515940. PMID: 30277102Free PMC Article
Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells.
Wang Y, Zhang WY, Han QW, Liu Y, Dai HR, Guo YL, Bo J, Fan H, Zhang Y, Zhang YJ, Chen MX, Feng KC, Wang QS, Fu XB, Han WD
Clin Immunol 2014 Dec;155(2):160-75. Epub 2014 Oct 16 doi: 10.1016/j.clim.2014.10.002. PMID: 25444722
Survival in advanced diffuse large B-cell lymphoma in pre- and post-rituximab Eras in the United States.
Shah BK, Bista A, Shafii B
Anticancer Res 2014 Sep;34(9):5117-20. PMID: 25202101
First-line therapy of CD20+ diffuse large B-cell lymphoma: facts and open questions.
Brusamolino E
Haematologica 2009 Sep;94(9):1194-8. doi: 10.3324/haematol.2009.011320. PMID: 19734413Free PMC Article

Prognosis

Development and validation of a novel prognostic nomogram for advanced diffuse large B cell lymphoma.
Wan M, Zhang W, Huang H, Fang X, Chen Y, Tian Y, Yao Y, Weng H, Chen Z, Yu L, Tian Y, Huang H, Li X, Hong H, Lin T
Clin Exp Med 2024 Mar 30;24(1):64. doi: 10.1007/s10238-024-01326-y. PMID: 38554186Free PMC Article
Obinutuzumab plus CHOP is effective and has a tolerable safety profile in previously untreated, advanced diffuse large B-cell lymphoma: the phase II GATHER study.
Sharman JP, Forero-Torres A, Costa LJ, Flinn IW, Inhorn L, Kelly K, Bessudo A, Fayad LE, Kaminski MS, Evens AM, Flowers CR, Sahin D, Mundt KE, Sandmann T, Fingerle-Rowson G, Vignal C, Mobasher M, Zelenetz AD
Leuk Lymphoma 2019 Apr;60(4):894-903. Epub 2018 Oct 2 doi: 10.1080/10428194.2018.1515940. PMID: 30277102Free PMC Article
Negative impact of concurrent overexpression of MYC and BCL2 in patients with advanced diffuse large B-cell lymphoma treated with dose-intensified immunochemotherapy.
Takahashi H, Miura K, Nakagawa M, Sugitani M, Amano Y, Kurita D, Sakagami M, Ohtake S, Uchino Y, Kodaira H, Iriyama N, Kobayashi S, Hojo A, Kobayashi Y, Hirabayashi Y, Kusuda M, Hatta Y, Nakayama T, Takei M
Leuk Lymphoma 2016 Dec;57(12):2784-2790. Epub 2016 Apr 13 doi: 10.3109/10428194.2016.1167205. PMID: 27071312
Survival in advanced diffuse large B-cell lymphoma in pre- and post-rituximab Eras in the United States.
Shah BK, Bista A, Shafii B
Anticancer Res 2014 Sep;34(9):5117-20. PMID: 25202101
Significance of tumor burden, vascular endothelial growth factor, lactate dehydrogenase and beta-2 microglobulin serum levels in advanced diffuse large B cell lymphoma.
Milanovic N, Matkovic S, Ristic D, Jelic S, Petrovic M
J BUON 2012 Jul-Sep;17(3):497-501. PMID: 23033288

Clinical prediction guides

Development and validation of a novel prognostic nomogram for advanced diffuse large B cell lymphoma.
Wan M, Zhang W, Huang H, Fang X, Chen Y, Tian Y, Yao Y, Weng H, Chen Z, Yu L, Tian Y, Huang H, Li X, Hong H, Lin T
Clin Exp Med 2024 Mar 30;24(1):64. doi: 10.1007/s10238-024-01326-y. PMID: 38554186Free PMC Article
Statins enhance the chemosensitivity of R-CHOP in diffuse large B-cell lymphoma.
Gouni S, Strati P, Toruner G, Aradhya A, Landgraf R, Bilbao D, Vega F, Agarwal NK
Leuk Lymphoma 2022 Jun;63(6):1302-1313. Epub 2021 Dec 31 doi: 10.1080/10428194.2021.2020782. PMID: 34969327
Survival in advanced diffuse large B-cell lymphoma in pre- and post-rituximab Eras in the United States.
Shah BK, Bista A, Shafii B
Anticancer Res 2014 Sep;34(9):5117-20. PMID: 25202101
Significance of tumor burden, vascular endothelial growth factor, lactate dehydrogenase and beta-2 microglobulin serum levels in advanced diffuse large B cell lymphoma.
Milanovic N, Matkovic S, Ristic D, Jelic S, Petrovic M
J BUON 2012 Jul-Sep;17(3):497-501. PMID: 23033288
A phase 2 trial of standard-dose cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) and rituximab plus bevacizumab for patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: SWOG 0515.
Stopeck AT, Unger JM, Rimsza LM, LeBlanc M, Farnsworth B, Iannone M, Glenn MJ, Fisher RI, Miller TP
Blood 2012 Aug 9;120(6):1210-7. Epub 2012 Jun 25 doi: 10.1182/blood-2012-04-423079. PMID: 22734071Free PMC Article

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