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Metastatic Primary Central Chondrosarcoma

MedGen UID:
1727227
•Concept ID:
C5418994
•
Neoplastic Process

Definition

Primary central chondrosarcoma that has spread from its original site of growth to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Primary Central Chondrosarcoma

Professional guidelines

PubMed

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678
Incidence, treatment and survival of paediatric patients with bone sarcomas in Finland from 1991 to 2005.
Serlo J, Tarkkanen M, Sampo M, Vettenranta K, Riikonen P, Helenius I
Acta Paediatr 2015 Jul;104(7):738-45. Epub 2015 Apr 6 doi: 10.1111/apa.12986. PMID: 25721807

Recent clinical studies

Etiology

Efficacy and safety of regorafenib in patients with metastatic or locally advanced chondrosarcoma: Results of a non-comparative, randomised, double-blind, placebo controlled, multicentre phase II study.
Duffaud F, Italiano A, Bompas E, Rios M, Penel N, Mir O, Piperno-Neumann S, Chevreau C, Delcambre C, Bertucci F, Boudou-Rouquette P, Cancel M, Perrin C, Saada-Bouzid E, Monard L, Schiffler C, Chaigneau L, Hervieu A, Collard O, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Eur J Cancer 2021 Jun;150:108-118. Epub 2021 Apr 22 doi: 10.1016/j.ejca.2021.03.039. PMID: 33895682
Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Survival and prognostic factors in conventional central chondrosarcoma.
Fromm J, Klein A, Baur-Melnyk A, Knösel T, Lindner L, Birkenmaier C, Roeder F, Jansson V, Dürr HR
BMC Cancer 2018 Aug 24;18(1):849. doi: 10.1186/s12885-018-4741-7. PMID: 30143018Free PMC Article
Primary thoracic sarcomas.
Gladish GW, Sabloff BM, Munden RF, Truong MT, Erasmus JJ, Chasen MH
Radiographics 2002 May-Jun;22(3):621-37. doi: 10.1148/radiographics.22.3.g02ma17621. PMID: 12006691
From the archives of the AFIP. Primary tumors of the spine: radiologic pathologic correlation.
Murphey MD, Andrews CL, Flemming DJ, Temple HT, Smith WS, Smirniotopoulos JG
Radiographics 1996 Sep;16(5):1131-58. doi: 10.1148/radiographics.16.5.8888395. PMID: 8888395

Diagnosis

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Thyroid metastasis from chondrosarcoma.
Wu ZH, Dai JY, Shi JN, Fang MY, Cao J
Medicine (Baltimore) 2019 Nov;98(47):e18043. doi: 10.1097/MD.0000000000018043. PMID: 31764826Free PMC Article
The imaging of cartilaginous bone tumours. II. Chondrosarcoma.
Douis H, Saifuddin A
Skeletal Radiol 2013 May;42(5):611-26. Epub 2012 Oct 4 doi: 10.1007/s00256-012-1521-3. PMID: 23053201
The clinical approach towards chondrosarcoma.
Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovée JV
Oncologist 2008 Mar;13(3):320-9. doi: 10.1634/theoncologist.2007-0237. PMID: 18378543
Primary thoracic sarcomas.
Gladish GW, Sabloff BM, Munden RF, Truong MT, Erasmus JJ, Chasen MH
Radiographics 2002 May-Jun;22(3):621-37. doi: 10.1148/radiographics.22.3.g02ma17621. PMID: 12006691

Therapy

A machine learning-based model for clinical prediction of distal metastasis in chondrosarcoma: a multicenter, retrospective study.
Wei J, Lu S, Liu W, Liu H, Feng L, Tao Y, Pu Z, Liu Q, Hu Z, Wang H, Li W, Kang W, Yin C, Feng Z
PeerJ 2023;11:e16485. Epub 2023 Dec 18 doi: 10.7717/peerj.16485. PMID: 38130920Free PMC Article
Efficacy and safety of regorafenib in patients with metastatic or locally advanced chondrosarcoma: Results of a non-comparative, randomised, double-blind, placebo controlled, multicentre phase II study.
Duffaud F, Italiano A, Bompas E, Rios M, Penel N, Mir O, Piperno-Neumann S, Chevreau C, Delcambre C, Bertucci F, Boudou-Rouquette P, Cancel M, Perrin C, Saada-Bouzid E, Monard L, Schiffler C, Chaigneau L, Hervieu A, Collard O, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Eur J Cancer 2021 Jun;150:108-118. Epub 2021 Apr 22 doi: 10.1016/j.ejca.2021.03.039. PMID: 33895682
Pazopanib for treatment of advanced extraskeletal myxoid chondrosarcoma: a multicentre, single-arm, phase 2 trial.
Stacchiotti S, Ferrari S, Redondo A, Hindi N, Palmerini E, Vaz Salgado MA, Frezza AM, Casali PG, Gutierrez A, Lopez-Pousa A, Grignani G, Italiano A, LeCesne A, Dumont S, Blay JY, Penel N, Bernabeu D, de Alava E, Karanian M, Morosi C, Brich S, Dagrada GP, Vallacchi V, Castelli C, Brenca M, Racanelli D, Maestro R, Collini P, Cruz J, Martin-Broto J
Lancet Oncol 2019 Sep;20(9):1252-1262. Epub 2019 Jul 19 doi: 10.1016/S1470-2045(19)30319-5. PMID: 31331701
Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Local Treatment with Adjuvant Therapy for Central Atypical Cartilaginous Tumors in the Long Bones: Analysis of Outcome and Complications in One Hundred and Eight Patients with a Minimum Follow-up of Two Years.
Dierselhuis EF, Gerbers JG, Ploegmakers JJ, Stevens M, Suurmeijer AJ, Jutte PC
J Bone Joint Surg Am 2016 Feb 17;98(4):303-13. doi: 10.2106/JBJS.O.00472. PMID: 26888678

Prognosis

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Thyroid metastasis from chondrosarcoma.
Wu ZH, Dai JY, Shi JN, Fang MY, Cao J
Medicine (Baltimore) 2019 Nov;98(47):e18043. doi: 10.1097/MD.0000000000018043. PMID: 31764826Free PMC Article
Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.
Duffaud F, Mir O, Boudou-Rouquette P, Piperno-Neumann S, Penel N, Bompas E, Delcambre C, Kalbacher E, Italiano A, Collard O, Chevreau C, Saada E, Isambert N, Delaye J, Schiffler C, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Lancet Oncol 2019 Jan;20(1):120-133. Epub 2018 Nov 23 doi: 10.1016/S1470-2045(18)30742-3. PMID: 30477937
Survival and prognostic factors in conventional central chondrosarcoma.
Fromm J, Klein A, Baur-Melnyk A, Knösel T, Lindner L, Birkenmaier C, Roeder F, Jansson V, Dürr HR
BMC Cancer 2018 Aug 24;18(1):849. doi: 10.1186/s12885-018-4741-7. PMID: 30143018Free PMC Article
The clinical approach towards chondrosarcoma.
Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovée JV
Oncologist 2008 Mar;13(3):320-9. doi: 10.1634/theoncologist.2007-0237. PMID: 18378543

Clinical prediction guides

A machine learning-based model for clinical prediction of distal metastasis in chondrosarcoma: a multicenter, retrospective study.
Wei J, Lu S, Liu W, Liu H, Feng L, Tao Y, Pu Z, Liu Q, Hu Z, Wang H, Li W, Kang W, Yin C, Feng Z
PeerJ 2023;11:e16485. Epub 2023 Dec 18 doi: 10.7717/peerj.16485. PMID: 38130920Free PMC Article
Repeated robotic pancreatectomy for recurrent pancreatic metastasis of mesenchymal chondrosarcoma: A case report.
Hayashida S, Ikenaga N, Nakata K, Nakamura S, Abe T, Ideno N, Endo M, Noguchi S, Oda Y, Nakamura M
Asian J Endosc Surg 2023 Oct;16(4):795-799. Epub 2023 Aug 13 doi: 10.1111/ases.13240. PMID: 37574440
TERT promoter mutation is an objective clinical marker for disease progression in chondrosarcoma.
Zhang Y, Chen Y, Yang C, Seger N, Hesla AC, Tsagkozis P, Larsson O, Lin Y, Haglund F
Mod Pathol 2021 Nov;34(11):2020-2027. Epub 2021 Jun 9 doi: 10.1038/s41379-021-00848-0. PMID: 34108637Free PMC Article
The diagnostic significance of pulmonary nodules on CT thorax in chondrosarcoma of bone.
McLoughlin E, Davies AM, Iqbal A, James SL, Botchu R
Clin Radiol 2020 May;75(5):395.e7-395.e16. Epub 2019 Dec 31 doi: 10.1016/j.crad.2019.11.017. PMID: 31898960
Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.
Zhu GG, Nafa K, Agaram N, Zehir A, Benayed R, Sadowska J, Borsu L, Kelly C, Tap WD, Fabbri N, Athanasian E, Boland PJ, Healey JH, Berger MF, Ladanyi M, Hameed M
Clin Cancer Res 2020 Jan 15;26(2):419-427. Epub 2019 Oct 15 doi: 10.1158/1078-0432.CCR-18-4212. PMID: 31615936Free PMC Article

Recent systematic reviews

Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones.
Dierselhuis EF, Goulding KA, Stevens M, Jutte PC
Cochrane Database Syst Rev 2019 Mar 7;3(3):CD010778. doi: 10.1002/14651858.CD010778.pub2. PMID: 30845364Free PMC Article

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