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Uveal Nevus

MedGen UID:
1727578
•Concept ID:
C5420815
•
Neoplastic Process

Definition

A benign nevus derived from melanocytes of the uveal tract. Only a small percentage of cases progress to uveal melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUveal Nevus

Professional guidelines

PubMed

PRAME is a useful marker for the differential diagnosis of melanocytic tumours and histological mimics.
Chen YP, Zhang WW, Qiu YT, Ke LF, Chen H, Chen G
Histopathology 2023 Jan;82(2):285-295. Epub 2022 Oct 13 doi: 10.1111/his.14814. PMID: 36200756
Presumed incipient choroidal melanoma: proposed diagnostic criteria and management.
Jouhi S, Al-Jamal RT, Täll M, Eskelin S, Kivelä TT
Br J Ophthalmol 2023 Mar;107(3):412-417. Epub 2021 Oct 19 doi: 10.1136/bjophthalmol-2020-318658. PMID: 34666992
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

Recent clinical studies

Etiology

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
Nell RJ, Menger NV, Versluis M, Luyten GPM, Verdijk RM, Madigan MC, Jager MJ, van der Velden PA
BMC Cancer 2021 Feb 15;21(1):164. doi: 10.1186/s12885-021-07865-x. PMID: 33588787Free PMC Article
Referral patterns of intraocular tumour patients to a dedicated Canadian ocular oncology department.
Law C, Krema H, Simpson ER
Can J Ophthalmol 2012 Jun;47(3):254-61. doi: 10.1016/j.jcjo.2012.03.047. PMID: 22687302

Diagnosis

Referral patterns of intraocular tumour patients to a dedicated Canadian ocular oncology department.
Law C, Krema H, Simpson ER
Can J Ophthalmol 2012 Jun;47(3):254-61. doi: 10.1016/j.jcjo.2012.03.047. PMID: 22687302

Prognosis

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
Nell RJ, Menger NV, Versluis M, Luyten GPM, Verdijk RM, Madigan MC, Jager MJ, van der Velden PA
BMC Cancer 2021 Feb 15;21(1):164. doi: 10.1186/s12885-021-07865-x. PMID: 33588787Free PMC Article

Clinical prediction guides

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
Nell RJ, Menger NV, Versluis M, Luyten GPM, Verdijk RM, Madigan MC, Jager MJ, van der Velden PA
BMC Cancer 2021 Feb 15;21(1):164. doi: 10.1186/s12885-021-07865-x. PMID: 33588787Free PMC Article

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