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Refractory Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:
1728246
•Concept ID:
C5419187
•
Neoplastic Process

Definition

Cutaneous squamous cell carcinoma of the head and neck that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Cutaneous Squamous Cell Carcinoma of the Head and Neck

Professional guidelines

PubMed

New and emerging drugs for the treatment of advanced cutaneous squamous cell carcinoma.
Bonini F, de Sousa LG, Ferrarotto R
Expert Opin Emerg Drugs 2023 Dec;28(2):97-106. Epub 2023 Jun 23 doi: 10.1080/14728214.2023.2208345. PMID: 37144289

Recent clinical studies

Etiology

Effectiveness and tolerance of electrochemotherapy as palliative therapy for patients with head and neck cancer and malignant melanoma and its relation to early skin reaction.
Caballero-Borrego M, Coll S, Navarrete P
Braz J Otorhinolaryngol 2024 Jan-Feb;90(1):101365. Epub 2023 Nov 22 doi: 10.1016/j.bjorl.2023.101365. PMID: 38006727Free PMC Article
Phase I/II clinical study on safety and antivascular effects of paclitaxel encapsulated in cationic liposomes for targeted therapy in advanced head and neck cancer.
Strieth S, Dunau C, Michaelis U, Jäger L, Gellrich D, Wollenberg B, Dellian M
Head Neck 2014 Jul;36(7):976-84. Epub 2013 Dec 11 doi: 10.1002/hed.23397. PMID: 23733258

Therapy

Effectiveness and tolerance of electrochemotherapy as palliative therapy for patients with head and neck cancer and malignant melanoma and its relation to early skin reaction.
Caballero-Borrego M, Coll S, Navarrete P
Braz J Otorhinolaryngol 2024 Jan-Feb;90(1):101365. Epub 2023 Nov 22 doi: 10.1016/j.bjorl.2023.101365. PMID: 38006727Free PMC Article
Combining Panitumumab With Anti-PD-1 Antibody in Cutaneous Squamous Cell Carcinoma of the Head and Neck After Inadequate Response to Anti-PD-1 Antibody Alone.
Hsu E, Eton O, Patel AV, Cartun R, Earle JS, Mnayer LO, Kotowitz J, Yu PP
J Drugs Dermatol 2021 Aug 1;20(8):901-904. doi: 10.36849/JDD.6175. PMID: 34397194
Pembrolizumab in Patients with Refractory Cutaneous Squamous Cell Carcinoma: A Phase II Trial.
Ferrarotto R, Sousa LG, Qing Y, Kaya D, Stephen B, Jain D, Bell D, Pant S, Tsimberidou AM, Janku F, Blumenschein G, Glisson BS, Ahnert JR, Piha-Paul SA, Lee JJ, Wong MK, Lu C, Meric-Bernstam F, Naing A
Adv Ther 2021 Aug;38(8):4581-4591. Epub 2021 Jul 9 doi: 10.1007/s12325-021-01807-6. PMID: 34241781
Cetuximab: a review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer.
Blick SK, Scott LJ
Drugs 2007;67(17):2585-607. doi: 10.2165/00003495-200767170-00008. PMID: 18034592
Use of becaplermin in the closure of pharyngocutaneous fistulas.
Jakubowicz DM, Smith RV
Head Neck 2005 May;27(5):433-8. doi: 10.1002/hed.20182. PMID: 15776464

Prognosis

Pembrolizumab in Patients with Refractory Cutaneous Squamous Cell Carcinoma: A Phase II Trial.
Ferrarotto R, Sousa LG, Qing Y, Kaya D, Stephen B, Jain D, Bell D, Pant S, Tsimberidou AM, Janku F, Blumenschein G, Glisson BS, Ahnert JR, Piha-Paul SA, Lee JJ, Wong MK, Lu C, Meric-Bernstam F, Naing A
Adv Ther 2021 Aug;38(8):4581-4591. Epub 2021 Jul 9 doi: 10.1007/s12325-021-01807-6. PMID: 34241781
Adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU-NSC 409462), and cyclophosphamide in refractory adenocarcinoma of the breast and other tumors.
Presant CA, Kolhouse JF, Klahr C
Cancer 1976 Feb;37(2):620-8. doi: 10.1002/1097-0142(197602)37:2<620::aid-cncr2820370203>3.0.co;2-d. PMID: 1253101

Clinical prediction guides

Effectiveness and tolerance of electrochemotherapy as palliative therapy for patients with head and neck cancer and malignant melanoma and its relation to early skin reaction.
Caballero-Borrego M, Coll S, Navarrete P
Braz J Otorhinolaryngol 2024 Jan-Feb;90(1):101365. Epub 2023 Nov 22 doi: 10.1016/j.bjorl.2023.101365. PMID: 38006727Free PMC Article
Comprehensive Mutational and Phenotypic Characterization of New Metastatic Cutaneous Squamous Cell Carcinoma Cell Lines Reveal Novel Drug Susceptibilities.
Perry J, Ashford B, Thind AS, Gauthier ME, Minaei E, Major G, Iyer NG, Gupta R, Clark J, Ranson M
Int J Mol Sci 2020 Dec 15;21(24) doi: 10.3390/ijms21249536. PMID: 33333825Free PMC Article
Adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU-NSC 409462), and cyclophosphamide in refractory adenocarcinoma of the breast and other tumors.
Presant CA, Kolhouse JF, Klahr C
Cancer 1976 Feb;37(2):620-8. doi: 10.1002/1097-0142(197602)37:2<620::aid-cncr2820370203>3.0.co;2-d. PMID: 1253101

Supplemental Content

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    Practice guidelines

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