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Steatohepatitic Hepatocellular Carcinoma

MedGen UID:
1728788
•Concept ID:
C5417718
•
Neoplastic Process

Definition

Hepatocellular carcinoma characterized by the presence of steatohepatitis features, including macrovesicular steatosis, fibrosis, ballooning of malignant hepatocytes, Mallory bodies, and inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteatohepatitic Hepatocellular Carcinoma

Recent clinical studies

Etiology

Pathological overview of steatohepatitic hepatocellular carcinoma in a surgical series.
Trapani L, Beaufrère A, Hobeika C, Codjia T, Albuquerque M, Bouattour M, Lesurtel M, Cauchy F, Paradis V
Histopathology 2023 Oct;83(4):526-537. Epub 2023 May 24 doi: 10.1111/his.14941. PMID: 37222200
Clinicopathological assessment of steatohepatitic hepatocellular carcinoma.
Yamaoka K, Saitoh S, Kinowaki K, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Suzuki F, Suzuki Y, Arase Y, Ikeda K, Fukusato T, Kumada H
Clin Res Hepatol Gastroenterol 2022 Oct;46(8):101799. Epub 2021 Sep 7 doi: 10.1016/j.clinre.2021.101799. PMID: 34500120
Steatotic and Steatohepatitic Hepatocellular Carcinomas: Features in a Series With Predominantly Viral Etiology.
Aykutlu U, Argon A, Orman M, Ulukaya S, Zeytunlu M, Karasu Z, Günşar F, Nart D, Akarca U, Yilmaz F
Am J Surg Pathol 2021 Sep 1;45(9):1252-1263. doi: 10.1097/PAS.0000000000001714. PMID: 33826548
Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis: A Study of 2 Cohorts With Molecular Insights.
Qin J, Higashi T, Nakagawa S, Fujiwara N, Yamashita YI, Beppu T, Baba H, Kobayashi M, Kumada H, Gunasekaran G, Schiano TD, Thung SN, Fiel MI, Hoshida Y, Ward SC
Am J Surg Pathol 2020 Oct;44(10):1406-1412. doi: 10.1097/PAS.0000000000001533. PMID: 32618599Free PMC Article
The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis.
Salomao M, Remotti H, Vaughan R, Siegel AB, Lefkowitch JH, Moreira RK
Hum Pathol 2012 May;43(5):737-46. Epub 2011 Oct 20 doi: 10.1016/j.humpath.2011.07.005. PMID: 22018903

Diagnosis

Clinicopathological assessment of steatohepatitic hepatocellular carcinoma.
Yamaoka K, Saitoh S, Kinowaki K, Fujiyama S, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Suzuki F, Suzuki Y, Arase Y, Ikeda K, Fukusato T, Kumada H
Clin Res Hepatol Gastroenterol 2022 Oct;46(8):101799. Epub 2021 Sep 7 doi: 10.1016/j.clinre.2021.101799. PMID: 34500120
Steatohepatitic hepatocellular carcinoma: imaging findings with clinicopathological correlation.
Inui S, Kondo H, Tanahashi Y, Fukukura Y, Sano K, Morisaka H, Saito K, Kondo F, Fukusato T, Furui S, Oba H
Clin Radiol 2021 Feb;76(2):160.e15-160.e25. Epub 2020 Oct 10 doi: 10.1016/j.crad.2020.09.011. PMID: 33046228
Steatohepatitic Variant of Hepatocellular Carcinoma Is Associated With Both Alcoholic Steatohepatitis and Nonalcoholic Steatohepatitis: A Study of 2 Cohorts With Molecular Insights.
Qin J, Higashi T, Nakagawa S, Fujiwara N, Yamashita YI, Beppu T, Baba H, Kobayashi M, Kumada H, Gunasekaran G, Schiano TD, Thung SN, Fiel MI, Hoshida Y, Ward SC
Am J Surg Pathol 2020 Oct;44(10):1406-1412. doi: 10.1097/PAS.0000000000001533. PMID: 32618599Free PMC Article
Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease.
Degasperi E, Colombo M
Lancet Gastroenterol Hepatol 2016 Oct;1(2):156-164. Epub 2016 Sep 8 doi: 10.1016/S2468-1253(16)30018-8. PMID: 28404072
The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis.
Salomao M, Remotti H, Vaughan R, Siegel AB, Lefkowitch JH, Moreira RK
Hum Pathol 2012 May;43(5):737-46. Epub 2011 Oct 20 doi: 10.1016/j.humpath.2011.07.005. PMID: 22018903

Prognosis

Imaging and prognostic characterization of fat-containing hepatocellular carcinoma subtypes.
Faure A, Dioguardi Burgio M, Cannella R, Sartoris R, Bouattour M, Hobeika C, Cauchy F, Trapani L, Beaufrère A, Vilgrain V, Ronot M
Radiol Med 2024 May;129(5):687-701. Epub 2024 Mar 21 doi: 10.1007/s11547-024-01807-w. PMID: 38512627
Pathological overview of steatohepatitic hepatocellular carcinoma in a surgical series.
Trapani L, Beaufrère A, Hobeika C, Codjia T, Albuquerque M, Bouattour M, Lesurtel M, Cauchy F, Paradis V
Histopathology 2023 Oct;83(4):526-537. Epub 2023 May 24 doi: 10.1111/his.14941. PMID: 37222200
Steatotic and Steatohepatitic Hepatocellular Carcinomas: Features in a Series With Predominantly Viral Etiology.
Aykutlu U, Argon A, Orman M, Ulukaya S, Zeytunlu M, Karasu Z, Günşar F, Nart D, Akarca U, Yilmaz F
Am J Surg Pathol 2021 Sep 1;45(9):1252-1263. doi: 10.1097/PAS.0000000000001714. PMID: 33826548
Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease.
Degasperi E, Colombo M
Lancet Gastroenterol Hepatol 2016 Oct;1(2):156-164. Epub 2016 Sep 8 doi: 10.1016/S2468-1253(16)30018-8. PMID: 28404072
Steatohepatitic hepatocellular carcinoma, a morphologic indicator of associated metabolic risk factors: a study from India.
Jain D, Nayak NC, Kumaran V, Saigal S
Arch Pathol Lab Med 2013 Jul;137(7):961-6. doi: 10.5858/arpa.2012-0048-OA. PMID: 23808468

Clinical prediction guides

Imaging and prognostic characterization of fat-containing hepatocellular carcinoma subtypes.
Faure A, Dioguardi Burgio M, Cannella R, Sartoris R, Bouattour M, Hobeika C, Cauchy F, Trapani L, Beaufrère A, Vilgrain V, Ronot M
Radiol Med 2024 May;129(5):687-701. Epub 2024 Mar 21 doi: 10.1007/s11547-024-01807-w. PMID: 38512627
Steatohepatitic hepatocellular carcinoma: imaging findings with clinicopathological correlation.
Inui S, Kondo H, Tanahashi Y, Fukukura Y, Sano K, Morisaka H, Saito K, Kondo F, Fukusato T, Furui S, Oba H
Clin Radiol 2021 Feb;76(2):160.e15-160.e25. Epub 2020 Oct 10 doi: 10.1016/j.crad.2020.09.011. PMID: 33046228
Steatohepatitic variant of hepatocellular carcinoma in the absence of metabolic syndrome or background steatosis: a clinical, pathological, and genetic study.
Yeh MM, Liu Y, Torbenson M
Hum Pathol 2015 Nov;46(11):1769-75. Epub 2015 Aug 4 doi: 10.1016/j.humpath.2015.07.018. PMID: 26410018
Steatohepatitic hepatocellular carcinoma, a morphologic indicator of associated metabolic risk factors: a study from India.
Jain D, Nayak NC, Kumaran V, Saigal S
Arch Pathol Lab Med 2013 Jul;137(7):961-6. doi: 10.5858/arpa.2012-0048-OA. PMID: 23808468

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