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Myocardial Hypertrophy

MedGen UID:
1730032
•Concept ID:
C3495916
•
Pathologic Function
Synonym: Myocardial hypertrophy

Definition

Thickening of the myocardium often due to chronic pressure overload. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial Hypertrophy

Professional guidelines

PubMed

Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Updates for the diagnosis and management of cardiac amyloidosis.
Gościniak P, Baron T, Milczarek S, Kostkiewicz M, Machaliński B
Adv Clin Exp Med 2022 Feb;31(2):175-185. doi: 10.17219/acem/142252. PMID: 35195962
Fabry disease: genetics, pathology, and treatment.
Bernardes TP, Foresto RD, Kirsztajn GM
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s10-s16. doi: 10.1590/1806-9282.66.S1.10. PMID: 31939530

Recent clinical studies

Etiology

Aldosterone as a Mediator of Cardiovascular Damage.
Buffolo F, Tetti M, Mulatero P, Monticone S
Hypertension 2022 Sep;79(9):1899-1911. Epub 2022 Jun 29 doi: 10.1161/HYPERTENSIONAHA.122.17964. PMID: 35766038
Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Cardiovascular complications of acromegaly.
Kamenický P, Maione L, Chanson P
Ann Endocrinol (Paris) 2021 Jun;82(3-4):206-209. Epub 2020 Mar 18 doi: 10.1016/j.ando.2020.03.010. PMID: 33168155
ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'.
Padro T, Manfrini O, Bugiardini R, Canty J, Cenko E, De Luca G, Duncker DJ, Eringa EC, Koller A, Tousoulis D, Trifunovic D, Vavlukis M, de Wit C, Badimon L
Cardiovasc Res 2020 Mar 1;116(4):741-755. doi: 10.1093/cvr/cvaa003. PMID: 32034397Free PMC Article
Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death.
Basso C, Iliceto S, Thiene G, Perazzolo Marra M
Circulation 2019 Sep 10;140(11):952-964. Epub 2019 Sep 9 doi: 10.1161/CIRCULATIONAHA.118.034075. PMID: 31498700

Diagnosis

Cardiovascular complications of acromegaly.
Kamenický P, Maione L, Chanson P
Ann Endocrinol (Paris) 2021 Jun;82(3-4):206-209. Epub 2020 Mar 18 doi: 10.1016/j.ando.2020.03.010. PMID: 33168155
ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'.
Padro T, Manfrini O, Bugiardini R, Canty J, Cenko E, De Luca G, Duncker DJ, Eringa EC, Koller A, Tousoulis D, Trifunovic D, Vavlukis M, de Wit C, Badimon L
Cardiovasc Res 2020 Mar 1;116(4):741-755. doi: 10.1093/cvr/cvaa003. PMID: 32034397Free PMC Article
Molecular biomarkers in cardiac hypertrophy.
Zhu L, Li C, Liu Q, Xu W, Zhou X
J Cell Mol Med 2019 Mar;23(3):1671-1677. Epub 2019 Jan 16 doi: 10.1111/jcmm.14129. PMID: 30648807Free PMC Article
Regulation of coronary blood flow during exercise.
Duncker DJ, Bache RJ
Physiol Rev 2008 Jul;88(3):1009-86. doi: 10.1152/physrev.00045.2006. PMID: 18626066
Hypertrophic cardiomyopathy.
Elliott P, McKenna WJ
Lancet 2004 Jun 5;363(9424):1881-91. doi: 10.1016/S0140-6736(04)16358-7. PMID: 15183628

Therapy

Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway.
Yan J, Li Z, Liang Y, Yang C, Ou W, Mo H, Tang M, Chen D, Zhong C, Que D, Feng L, Xiao H, Song X, Yang P
Food Funct 2023 Nov 13;14(22):10052-10068. doi: 10.1039/d3fo02633g. PMID: 37861458
Aldosterone as a Mediator of Cardiovascular Damage.
Buffolo F, Tetti M, Mulatero P, Monticone S
Hypertension 2022 Sep;79(9):1899-1911. Epub 2022 Jun 29 doi: 10.1161/HYPERTENSIONAHA.122.17964. PMID: 35766038
Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway.
Ren B, Feng J, Yang N, Guo Y, Chen C, Qin Q
Int Immunopharmacol 2021 Sep;98:107841. Epub 2021 Jun 18 doi: 10.1016/j.intimp.2021.107841. PMID: 34153662
Adverse effects of doping with anabolic androgenic steroids in competitive athletics, recreational sports and bodybuilding.
Vorona E, Nieschlag E
Minerva Endocrinol 2018 Dec;43(4):476-488. Epub 2018 Feb 19 doi: 10.23736/S0391-1977.18.02810-9. PMID: 29463075
Myocardial reverse remodeling.
Hellawell JL, Margulies KB
Cardiovasc Ther 2012 Jun;30(3):172-81. Epub 2010 Nov 25 doi: 10.1111/j.1755-5922.2010.00247.x. PMID: 21108773

Prognosis

Recent advances on the roles of LncRNAs in cardiovascular disease.
Fang Y, Xu Y, Wang R, Hu L, Guo D, Xue F, Guo W, Zhang D, Hu J, Li Y, Zhang W, Zhang M
J Cell Mol Med 2020 Nov;24(21):12246-12257. Epub 2020 Sep 24 doi: 10.1111/jcmm.15880. PMID: 32969576Free PMC Article
ESC Working Group on Coronary Pathophysiology and Microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'.
Padro T, Manfrini O, Bugiardini R, Canty J, Cenko E, De Luca G, Duncker DJ, Eringa EC, Koller A, Tousoulis D, Trifunovic D, Vavlukis M, de Wit C, Badimon L
Cardiovasc Res 2020 Mar 1;116(4):741-755. doi: 10.1093/cvr/cvaa003. PMID: 32034397Free PMC Article
Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death.
Basso C, Iliceto S, Thiene G, Perazzolo Marra M
Circulation 2019 Sep 10;140(11):952-964. Epub 2019 Sep 9 doi: 10.1161/CIRCULATIONAHA.118.034075. PMID: 31498700
Multimodality Imaging Markers of Adverse Myocardial Remodeling in Aortic Stenosis.
Treibel TA, Badiani S, Lloyd G, Moon JC
JACC Cardiovasc Imaging 2019 Aug;12(8 Pt 1):1532-1548. doi: 10.1016/j.jcmg.2019.02.034. PMID: 31395243
Hypertrophic cardiomyopathy.
Elliott P, McKenna WJ
Lancet 2004 Jun 5;363(9424):1881-91. doi: 10.1016/S0140-6736(04)16358-7. PMID: 15183628

Clinical prediction guides

Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms.
Silva Andrade B, Siqueira S, de Assis Soares WR, de Souza Rangel F, Santos NO, Dos Santos Freitas A, Ribeiro da Silveira P, Tiwari S, Alzahrani KJ, Góes-Neto A, Azevedo V, Ghosh P, Barh D
Viruses 2021 Apr 18;13(4) doi: 10.3390/v13040700. PMID: 33919537Free PMC Article
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Zhang N, Zhang Y, Qian H, Wu S, Cao L, Sun Y
Cell Death Differ 2020 Sep;27(9):2605-2619. Epub 2020 Mar 5 doi: 10.1038/s41418-020-0523-2. PMID: 32139900Free PMC Article
Adverse effects of doping with anabolic androgenic steroids in competitive athletics, recreational sports and bodybuilding.
Vorona E, Nieschlag E
Minerva Endocrinol 2018 Dec;43(4):476-488. Epub 2018 Feb 19 doi: 10.23736/S0391-1977.18.02810-9. PMID: 29463075
Periodontitis and myocardial hypertrophy.
Suzuki JI, Sato H, Kaneko M, Yoshida A, Aoyama N, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Izumi Y, Isobe M, Komuro I
Hypertens Res 2017 Apr;40(4):324-328. Epub 2016 Nov 10 doi: 10.1038/hr.2016.146. PMID: 27829660

Recent systematic reviews

Progress in the treatment of diabetic cardiomyopathy, a systematic review.
Shou Y, Li X, Fang Q, Xie A, Zhang Y, Fu X, Wang M, Gong W, Zhang X, Yang D
Pharmacol Res Perspect 2024 Apr;12(2):e1177. doi: 10.1002/prp2.1177. PMID: 38407563Free PMC Article
Crosstalk between microRNA and Oxidative Stress in Heart Failure: A Systematic Review.
Klimczak-Tomaniak D, Haponiuk-Skwarlińska J, Kuch M, Pączek L
Int J Mol Sci 2022 Nov 30;23(23) doi: 10.3390/ijms232315013. PMID: 36499336Free PMC Article
Amygdalin - A pharmacological and toxicological review.
He XY, Wu LJ, Wang WX, Xie PJ, Chen YH, Wang F
J Ethnopharmacol 2020 May 23;254:112717. Epub 2020 Feb 27 doi: 10.1016/j.jep.2020.112717. PMID: 32114166

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