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Adverse Drug Reaction to Systemic Antibiotic

MedGen UID:
1731467
•Concept ID:
C5419044
•
Pathologic Function
Synonym: Adverse Drug Reaction to Systemic Antibiotics

Definition

A detrimental or unintended response associated with the use of a systemic antibiotic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdverse Drug Reaction to Systemic Antibiotic

Professional guidelines

PubMed

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome.
Cabañas R, Ramírez E, Sendagorta E, Alamar R, Barranco R, Blanca-López N, Doña I, Fernández J, Garcia-Nunez I, García-Samaniego J, Lopez-Rico R, Marín-Serrano E, Mérida C, Moya M, Ortega-Rodríguez NR, Rivas Becerra B, Rojas-Perez-Ezquerra P, Sánchez-González MJ, Vega-Cabrera C, Vila-Albelda C, Bellón T
J Investig Allergol Clin Immunol 2020;30(4):229-253. Epub 2020 Jan 14 doi: 10.18176/jiaci.0480. PMID: 31932268
Skin test concentrations for systemically administered drugs -- an ENDA/EAACI Drug Allergy Interest Group position paper.
Brockow K, Garvey LH, Aberer W, Atanaskovic-Markovic M, Barbaud A, Bilo MB, Bircher A, Blanca M, Bonadonna B, Campi P, Castro E, Cernadas JR, Chiriac AM, Demoly P, Grosber M, Gooi J, Lombardo C, Mertes PM, Mosbech H, Nasser S, Pagani M, Ring J, Romano A, Scherer K, Schnyder B, Testi S, Torres M, Trautmann A, Terreehorst I; ENDA/EAACI Drug Allergy Interest Group
Allergy 2013 Jun;68(6):702-12. Epub 2013 Apr 25 doi: 10.1111/all.12142. PMID: 23617635

Recent clinical studies

Etiology

Sulfonamide Hypersensitivity.
Chow TG, Khan DA
Clin Rev Allergy Immunol 2022 Jun;62(3):400-412. Epub 2021 Jul 1 doi: 10.1007/s12016-021-08872-3. PMID: 34212341
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review.
Sharifzadeh S, Mohammadpour AH, Tavanaee A, Elyasi S
Eur J Clin Pharmacol 2021 Mar;77(3):275-289. Epub 2020 Oct 6 doi: 10.1007/s00228-020-03005-9. PMID: 33025080Free PMC Article
Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome.
Cabañas R, Ramírez E, Sendagorta E, Alamar R, Barranco R, Blanca-López N, Doña I, Fernández J, Garcia-Nunez I, García-Samaniego J, Lopez-Rico R, Marín-Serrano E, Mérida C, Moya M, Ortega-Rodríguez NR, Rivas Becerra B, Rojas-Perez-Ezquerra P, Sánchez-González MJ, Vega-Cabrera C, Vila-Albelda C, Bellón T
J Investig Allergol Clin Immunol 2020;30(4):229-253. Epub 2020 Jan 14 doi: 10.18176/jiaci.0480. PMID: 31932268
Safety of dermatologic medications in pregnancy and lactation: Part I. Pregnancy.
Murase JE, Heller MM, Butler DC
J Am Acad Dermatol 2014 Mar;70(3):401.e1-14; quiz 415. doi: 10.1016/j.jaad.2013.09.010. PMID: 24528911
Drug-induced sialorrhea.
Freudenreich O
Drugs Today (Barc) 2005 Jun;41(6):411-8. doi: 10.1358/dot.2005.41.6.893628. PMID: 16110348

Diagnosis

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole.
Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Sulfonamide Hypersensitivity.
Chow TG, Khan DA
Clin Rev Allergy Immunol 2022 Jun;62(3):400-412. Epub 2021 Jul 1 doi: 10.1007/s12016-021-08872-3. PMID: 34212341
Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome.
Cabañas R, Ramírez E, Sendagorta E, Alamar R, Barranco R, Blanca-López N, Doña I, Fernández J, Garcia-Nunez I, García-Samaniego J, Lopez-Rico R, Marín-Serrano E, Mérida C, Moya M, Ortega-Rodríguez NR, Rivas Becerra B, Rojas-Perez-Ezquerra P, Sánchez-González MJ, Vega-Cabrera C, Vila-Albelda C, Bellón T
J Investig Allergol Clin Immunol 2020;30(4):229-253. Epub 2020 Jan 14 doi: 10.18176/jiaci.0480. PMID: 31932268
Sulfonamide Hypersensitivity: Fact and Fiction.
Khan DA, Knowles SR, Shear NH
J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2116-2123. doi: 10.1016/j.jaip.2019.05.034. PMID: 31495421
Safety of dermatologic medications in pregnancy and lactation: Part I. Pregnancy.
Murase JE, Heller MM, Butler DC
J Am Acad Dermatol 2014 Mar;70(3):401.e1-14; quiz 415. doi: 10.1016/j.jaad.2013.09.010. PMID: 24528911

Therapy

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole.
Dilley M, Geng B
Clin Rev Allergy Immunol 2022 Jun;62(3):463-475. Epub 2021 Dec 15 doi: 10.1007/s12016-021-08878-x. PMID: 34910281Free PMC Article
Sulfonamide Hypersensitivity.
Chow TG, Khan DA
Clin Rev Allergy Immunol 2022 Jun;62(3):400-412. Epub 2021 Jul 1 doi: 10.1007/s12016-021-08872-3. PMID: 34212341
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review.
Sharifzadeh S, Mohammadpour AH, Tavanaee A, Elyasi S
Eur J Clin Pharmacol 2021 Mar;77(3):275-289. Epub 2020 Oct 6 doi: 10.1007/s00228-020-03005-9. PMID: 33025080Free PMC Article
Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome.
Cabañas R, Ramírez E, Sendagorta E, Alamar R, Barranco R, Blanca-López N, Doña I, Fernández J, Garcia-Nunez I, García-Samaniego J, Lopez-Rico R, Marín-Serrano E, Mérida C, Moya M, Ortega-Rodríguez NR, Rivas Becerra B, Rojas-Perez-Ezquerra P, Sánchez-González MJ, Vega-Cabrera C, Vila-Albelda C, Bellón T
J Investig Allergol Clin Immunol 2020;30(4):229-253. Epub 2020 Jan 14 doi: 10.18176/jiaci.0480. PMID: 31932268
Safety of dermatologic medications in pregnancy and lactation: Part I. Pregnancy.
Murase JE, Heller MM, Butler DC
J Am Acad Dermatol 2014 Mar;70(3):401.e1-14; quiz 415. doi: 10.1016/j.jaad.2013.09.010. PMID: 24528911

Prognosis

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. Part I. Epidemiology, pathogenesis, clinicopathological features, and prognosis.
Wei BM, Fox LP, Kaffenberger BH, Korman AM, Micheletti RG, Mostaghimi A, Noe MH, Rosenbach M, Shinkai K, Kwah JH, Phillips EJ, Bolognia JL, Damsky W, Nelson CA
J Am Acad Dermatol 2024 May;90(5):885-908. Epub 2023 Jul 27 doi: 10.1016/j.jaad.2023.02.072. PMID: 37516359
Practical management of suspected hypersensitivity reactions to anti-tuberculosis drugs.
Bermingham WH, Bhogal R, Arudi Nagarajan S, Mutlu L, El-Shabrawy RM, Madhan R, Krishnaswamy UM, Murali MR, Kudagammana ST, Shrestha R, Sumantri S, Christopher DJ, Mahesh PA, Dedicoat M, Krishna MT
Clin Exp Allergy 2022 Mar;52(3):375-386. Epub 2022 Jan 20 doi: 10.1111/cea.14084. PMID: 34939251
Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline.
Freyer DR, Brock PR, Chang KW, Dupuis LL, Epelman S, Knight K, Mills D, Phillips R, Potter E, Risby D, Simpkin P, Sullivan M, Cabral S, Robinson PD, Sung L
Lancet Child Adolesc Health 2020 Feb;4(2):141-150. Epub 2019 Dec 19 doi: 10.1016/S2352-4642(19)30336-0. PMID: 31866182Free PMC Article
Association of Adverse Events With Antibiotic Use in Hospitalized Patients.
Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE
JAMA Intern Med 2017 Sep 1;177(9):1308-1315. doi: 10.1001/jamainternmed.2017.1938. PMID: 28604925Free PMC Article
Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review.
Canavan TN, Mathes EF, Frieden I, Shinkai K
J Am Acad Dermatol 2015 Feb;72(2):239-45. doi: 10.1016/j.jaad.2014.06.026. PMID: 25592340

Clinical prediction guides

Drug Reaction With Eosinophilia and Systemic Symptoms: A Systematic Review.
Awad A, Goh MS, Trubiano JA
J Allergy Clin Immunol Pract 2023 Jun;11(6):1856-1868. Epub 2023 Mar 7 doi: 10.1016/j.jaip.2023.02.035. PMID: 36893848
Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis.
Lee EY, Knox C, Phillips EJ
JAMA Dermatol 2023 Apr 1;159(4):384-392. doi: 10.1001/jamadermatol.2022.6378. PMID: 36790777Free PMC Article
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Practical management of suspected hypersensitivity reactions to anti-tuberculosis drugs.
Bermingham WH, Bhogal R, Arudi Nagarajan S, Mutlu L, El-Shabrawy RM, Madhan R, Krishnaswamy UM, Murali MR, Kudagammana ST, Shrestha R, Sumantri S, Christopher DJ, Mahesh PA, Dedicoat M, Krishna MT
Clin Exp Allergy 2022 Mar;52(3):375-386. Epub 2022 Jan 20 doi: 10.1111/cea.14084. PMID: 34939251
Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study.
Kardaun SH, Sekula P, Valeyrie-Allanore L, Liss Y, Chu CY, Creamer D, Sidoroff A, Naldi L, Mockenhaupt M, Roujeau JC; RegiSCAR study group
Br J Dermatol 2013 Nov;169(5):1071-80. doi: 10.1111/bjd.12501. PMID: 23855313

Recent systematic reviews

A Systematic Review and Meta-Analysis of Tuberculous Preventative Therapy Adverse Events.
Melnychuk L, Perlman-Arrow S, Lisboa Bastos M, Menzies D
Clin Infect Dis 2023 Jul 26;77(2):287-294. doi: 10.1093/cid/ciad246. PMID: 37125482
Drug Reaction With Eosinophilia and Systemic Symptoms: A Systematic Review.
Awad A, Goh MS, Trubiano JA
J Allergy Clin Immunol Pract 2023 Jun;11(6):1856-1868. Epub 2023 Mar 7 doi: 10.1016/j.jaip.2023.02.035. PMID: 36893848
Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis.
Lee EY, Knox C, Phillips EJ
JAMA Dermatol 2023 Apr 1;159(4):384-392. doi: 10.1001/jamadermatol.2022.6378. PMID: 36790777Free PMC Article
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.
Jacobsen A, Olabi B, Langley A, Beecker J, Mutter E, Shelley A, Worley B, Ramsay T, Saavedra A, Parker R, Stewart F, Pardo Pardo J
Cochrane Database Syst Rev 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2. PMID: 35274741Free PMC Article
Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review.
Canavan TN, Mathes EF, Frieden I, Shinkai K
J Am Acad Dermatol 2015 Feb;72(2):239-45. doi: 10.1016/j.jaad.2014.06.026. PMID: 25592340

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