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Unresectable Cervical Adenosquamous Carcinoma

MedGen UID:
1740825
•Concept ID:
C5420532
•
Neoplastic Process

Definition

Cervical adenosquamous carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Cervical Adenosquamous Carcinoma

Professional guidelines

PubMed

Clinical implications of human papillomavirus genotype in cervical adeno-adenosquamous carcinoma.
Lai CH, Chou HH, Chang CJ, Wang CC, Hsueh S, Huang YT, Chen YR, Chang HP, Chang SC, Lin CT, Chao A, Qiu JT, Huang KG, Chen TC, Jao MS, Chen MY, Liou JD, Huang CC, Chang TC, Patsner B
Eur J Cancer 2013 Feb;49(3):633-41. Epub 2012 Sep 29 doi: 10.1016/j.ejca.2012.09.008. PMID: 23031554
Methyl-CCNU, doxorubicin, and cis-diamminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix.
Carlson JA Jr, Day TG, Allegra JC, Woodcock TM, Greenberg RA, Masterson BJ
Cancer 1984 Jul 15;54(2):211-4. doi: 10.1002/1097-0142(19840715)54:2<211::aid-cncr2820540206>3.0.co;2-e. PMID: 6539161

Recent clinical studies

Etiology

Efficacy of lymph node dissection on stage IIICr of cervical cancer before CCRT: study protocol for a phase III, randomized controlled clinical trial (CQGOG0103).
He M, Guo M, Zhou Q, Tang Y, Zhong L, Liu Q, Fan X, Zhao X, Zhang X, Chen G, Shen Y, Xu Q, Chen X, Li Y, Zou D
J Gynecol Oncol 2023 May;34(3):e55. Epub 2023 Mar 23 doi: 10.3802/jgo.2023.34.e55. PMID: 36998225Free PMC Article
Dose-volume effects in pathologic lymph nodes in locally advanced cervical cancer.
Bacorro W, Dumas I, Escande A, Gouy S, Bentivegna E, Morice P, Haie-Meder C, Chargari C
Gynecol Oncol 2018 Mar;148(3):461-467. Epub 2018 Jan 8 doi: 10.1016/j.ygyno.2017.12.028. PMID: 29325690
Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase II studies.
Duenas-Gonzalez A, Lopez-Graniel C, Gonzalez-Enciso A, Mohar A, Rivera L, Mota A, Guadarrama R, Chanona G, De La Garza J
Ann Oncol 2002 Aug;13(8):1212-9. doi: 10.1093/annonc/mdf196. PMID: 12181244
Cervical cancer with paraaortic metastases: significance of residual paraaortic disease after surgical staging.
Kim PY, Monk BJ, Chabra S, Burger RA, Vasilev SA, Manetta A, DiSaia PJ, Berman ML
Gynecol Oncol 1998 Jun;69(3):243-7. doi: 10.1006/gyno.1998.5012. PMID: 9648595
A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas.
Hoffman JP, Weese JL, Solin LJ, Engstrom P, Agarwal P, Barber LW, Guttmann MC, Litwin S, Salazar H, Eisenberg BL
Am J Surg 1995 Jan;169(1):71-7; discussion 77-8. doi: 10.1016/s0002-9610(99)80112-3. PMID: 7818001

Diagnosis

Dose-volume effects in pathologic lymph nodes in locally advanced cervical cancer.
Bacorro W, Dumas I, Escande A, Gouy S, Bentivegna E, Morice P, Haie-Meder C, Chargari C
Gynecol Oncol 2018 Mar;148(3):461-467. Epub 2018 Jan 8 doi: 10.1016/j.ygyno.2017.12.028. PMID: 29325690
HPV in situ hybridization with catalyzed signal amplification and polymerase chain reaction in establishing cerebellar metastasis of a cervical carcinoma.
Huang CC, Kashima ML, Chen H, Shih IM, Kurman RJ, Wu TC
Hum Pathol 1999 May;30(5):587-91. doi: 10.1016/s0046-8177(99)90206-x. PMID: 10333232
A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas.
Hoffman JP, Weese JL, Solin LJ, Engstrom P, Agarwal P, Barber LW, Guttmann MC, Litwin S, Salazar H, Eisenberg BL
Am J Surg 1995 Jan;169(1):71-7; discussion 77-8. doi: 10.1016/s0002-9610(99)80112-3. PMID: 7818001

Therapy

Efficacy of lymph node dissection on stage IIICr of cervical cancer before CCRT: study protocol for a phase III, randomized controlled clinical trial (CQGOG0103).
He M, Guo M, Zhou Q, Tang Y, Zhong L, Liu Q, Fan X, Zhao X, Zhang X, Chen G, Shen Y, Xu Q, Chen X, Li Y, Zou D
J Gynecol Oncol 2023 May;34(3):e55. Epub 2023 Mar 23 doi: 10.3802/jgo.2023.34.e55. PMID: 36998225Free PMC Article
Dose-volume effects in pathologic lymph nodes in locally advanced cervical cancer.
Bacorro W, Dumas I, Escande A, Gouy S, Bentivegna E, Morice P, Haie-Meder C, Chargari C
Gynecol Oncol 2018 Mar;148(3):461-467. Epub 2018 Jan 8 doi: 10.1016/j.ygyno.2017.12.028. PMID: 29325690
Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase II studies.
Duenas-Gonzalez A, Lopez-Graniel C, Gonzalez-Enciso A, Mohar A, Rivera L, Mota A, Guadarrama R, Chanona G, De La Garza J
Ann Oncol 2002 Aug;13(8):1212-9. doi: 10.1093/annonc/mdf196. PMID: 12181244
A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas.
Hoffman JP, Weese JL, Solin LJ, Engstrom P, Agarwal P, Barber LW, Guttmann MC, Litwin S, Salazar H, Eisenberg BL
Am J Surg 1995 Jan;169(1):71-7; discussion 77-8. doi: 10.1016/s0002-9610(99)80112-3. PMID: 7818001
Methyl-CCNU, doxorubicin, and cis-diamminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix.
Carlson JA Jr, Day TG, Allegra JC, Woodcock TM, Greenberg RA, Masterson BJ
Cancer 1984 Jul 15;54(2):211-4. doi: 10.1002/1097-0142(19840715)54:2<211::aid-cncr2820540206>3.0.co;2-e. PMID: 6539161

Prognosis

Clinical implications of human papillomavirus genotype in cervical adeno-adenosquamous carcinoma.
Lai CH, Chou HH, Chang CJ, Wang CC, Hsueh S, Huang YT, Chen YR, Chang HP, Chang SC, Lin CT, Chao A, Qiu JT, Huang KG, Chen TC, Jao MS, Chen MY, Liou JD, Huang CC, Chang TC, Patsner B
Eur J Cancer 2013 Feb;49(3):633-41. Epub 2012 Sep 29 doi: 10.1016/j.ejca.2012.09.008. PMID: 23031554
Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase II studies.
Duenas-Gonzalez A, Lopez-Graniel C, Gonzalez-Enciso A, Mohar A, Rivera L, Mota A, Guadarrama R, Chanona G, De La Garza J
Ann Oncol 2002 Aug;13(8):1212-9. doi: 10.1093/annonc/mdf196. PMID: 12181244
Cervical cancer with paraaortic metastases: significance of residual paraaortic disease after surgical staging.
Kim PY, Monk BJ, Chabra S, Burger RA, Vasilev SA, Manetta A, DiSaia PJ, Berman ML
Gynecol Oncol 1998 Jun;69(3):243-7. doi: 10.1006/gyno.1998.5012. PMID: 9648595
5-year results of postoperative extended-field irradiation on 76 patients with nodal metastases from cervical carcinoma stages IB to IIIB.
Inoue T, Morita K
Cancer 1988 May 15;61(10):2009-14. doi: 10.1002/1097-0142(19880515)61:10<2009::aid-cncr2820611013>3.0.co;2-r. PMID: 3129178
Methyl-CCNU, doxorubicin, and cis-diamminedichloroplatinum II in the management of recurrent and metastatic squamous carcinoma of the cervix.
Carlson JA Jr, Day TG, Allegra JC, Woodcock TM, Greenberg RA, Masterson BJ
Cancer 1984 Jul 15;54(2):211-4. doi: 10.1002/1097-0142(19840715)54:2<211::aid-cncr2820540206>3.0.co;2-e. PMID: 6539161

Clinical prediction guides

Clinical implications of human papillomavirus genotype in cervical adeno-adenosquamous carcinoma.
Lai CH, Chou HH, Chang CJ, Wang CC, Hsueh S, Huang YT, Chen YR, Chang HP, Chang SC, Lin CT, Chao A, Qiu JT, Huang KG, Chen TC, Jao MS, Chen MY, Liou JD, Huang CC, Chang TC, Patsner B
Eur J Cancer 2013 Feb;49(3):633-41. Epub 2012 Sep 29 doi: 10.1016/j.ejca.2012.09.008. PMID: 23031554
Cervical cancer with paraaortic metastases: significance of residual paraaortic disease after surgical staging.
Kim PY, Monk BJ, Chabra S, Burger RA, Vasilev SA, Manetta A, DiSaia PJ, Berman ML
Gynecol Oncol 1998 Jun;69(3):243-7. doi: 10.1006/gyno.1998.5012. PMID: 9648595

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