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Inappropriate absence of fever

MedGen UID:
1745742
•Concept ID:
C5421614
•
Finding
HPO: HP:0033104

Definition

Failure to develop fever in the presence of an infection that normally would be expected to elicit a febrile response. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInappropriate absence of fever

Conditions with this feature

Hyper-IgE recurrent infection syndrome 5, autosomal recessive
MedGen UID:
1716052
•Concept ID:
C5394550
•
Disease or Syndrome
Hyper-IgE syndrome-5 with recurrent infections (HEIS5) is an autosomal recessive immunologic disorder characterized by onset of recurrent sinopulmonary and deep skin infections in early childhood. The infections are mostly caused by bacteria, including H. influenza and Staphylococcus aureus. Additional features include atopic dermatitis, impaired inflammatory responses during infection, increased serum IgE, and increased IL6 (147620) (summary by Spencer et al., 2019). For a discussion of genetic heterogeneity of hyper-IgE syndrome, see HIES1 (147060).
See: Condition Record
Hyper-IgE recurrent infection syndrome 5, autosomal recessive

Professional guidelines

PubMed

Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917. PMID: 30921525
Clinical Practice Guideline: Tonsillectomy in Children (Update).
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(1_suppl):S1-S42. doi: 10.1177/0194599818801757. PMID: 30798778
Management of Pediatric Febrile Seizures.
Laino D, Mencaroni E, Esposito S
Int J Environ Res Public Health 2018 Oct 12;15(10) doi: 10.3390/ijerph15102232. PMID: 30321985Free PMC Article

Recent clinical studies

Etiology

A predictive model of inappropriate use of medical tests and medications in Bronchiolitis.
Buendía JA, Rodríguez CA
Pan Afr Med J 2020;37:94. Epub 2020 Sep 25 doi: 10.11604/pamj.2020.37.94.22712. PMID: 33425127Free PMC Article
Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917. PMID: 30921525
Clinical Practice Guideline: Tonsillectomy in Children (Update).
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(1_suppl):S1-S42. doi: 10.1177/0194599818801757. PMID: 30798778
Challenges in Treatment of Inappropriate Sinus Tachycardia.
Ruzieh M, Moustafa A, Sabbagh E, Karim MM, Karim S
Curr Cardiol Rev 2018 Mar 14;14(1):42-44. doi: 10.2174/1573403X13666171129183826. PMID: 29189171Free PMC Article
Childhood fever.
Chong CY, Allen DM
Singapore Med J 1996 Feb;37(1):96-100. PMID: 8783923

Diagnosis

A predictive model of inappropriate use of medical tests and medications in Bronchiolitis.
Buendía JA, Rodríguez CA
Pan Afr Med J 2020;37:94. Epub 2020 Sep 25 doi: 10.11604/pamj.2020.37.94.22712. PMID: 33425127Free PMC Article
Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917. PMID: 30921525
Management of Pediatric Febrile Seizures.
Laino D, Mencaroni E, Esposito S
Int J Environ Res Public Health 2018 Oct 12;15(10) doi: 10.3390/ijerph15102232. PMID: 30321985Free PMC Article
Challenges in Treatment of Inappropriate Sinus Tachycardia.
Ruzieh M, Moustafa A, Sabbagh E, Karim MM, Karim S
Curr Cardiol Rev 2018 Mar 14;14(1):42-44. doi: 10.2174/1573403X13666171129183826. PMID: 29189171Free PMC Article
Diagnosis and treatment of acute pyelonephritis in women.
Colgan R, Williams M, Johnson JR
Am Fam Physician 2011 Sep 1;84(5):519-26. PMID: 21888302

Therapy

A prospective study of epidemiology characteristics and outcomes of bloodstream infections in older patients.
Moschou A, Ioannou P, Maraki S, Koutroumpakis F, Mamaloukaki M, Bikis C, Samonis G, Papadakis JA, Kofteridis DP
Australas J Ageing 2021 Sep;40(3):e182-e189. Epub 2020 Nov 10 doi: 10.1111/ajag.12881. PMID: 33174381
Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917. PMID: 30921525
Clinical Practice Guideline: Tonsillectomy in Children (Update).
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(1_suppl):S1-S42. doi: 10.1177/0194599818801757. PMID: 30798778
Diagnosis and treatment of acute pyelonephritis in women.
Colgan R, Williams M, Johnson JR
Am Fam Physician 2011 Sep 1;84(5):519-26. PMID: 21888302
Childhood fever.
Chong CY, Allen DM
Singapore Med J 1996 Feb;37(1):96-100. PMID: 8783923

Prognosis

Prevalence, Predictors and Point of View Toward Self-Medication Among Residents of Riyadh, Saudi Arabia: A Cross-Sectional Study.
Mannasaheb BA, Alajlan SA, Alshahrani JA, Othman N, Alolayan SO, Alamrah MS, Asdaq SMB, Al-Qahtani AM, Shaikh IA, Alasmary MY
Front Public Health 2022;10:862301. Epub 2022 Mar 25 doi: 10.3389/fpubh.2022.862301. PMID: 35400077Free PMC Article
A prospective study of epidemiology characteristics and outcomes of bloodstream infections in older patients.
Moschou A, Ioannou P, Maraki S, Koutroumpakis F, Mamaloukaki M, Bikis C, Samonis G, Papadakis JA, Kofteridis DP
Australas J Ageing 2021 Sep;40(3):e182-e189. Epub 2020 Nov 10 doi: 10.1111/ajag.12881. PMID: 33174381
A predictive model of inappropriate use of medical tests and medications in Bronchiolitis.
Buendía JA, Rodríguez CA
Pan Afr Med J 2020;37:94. Epub 2020 Sep 25 doi: 10.11604/pamj.2020.37.94.22712. PMID: 33425127Free PMC Article
Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917. PMID: 30921525
Management of Pediatric Febrile Seizures.
Laino D, Mencaroni E, Esposito S
Int J Environ Res Public Health 2018 Oct 12;15(10) doi: 10.3390/ijerph15102232. PMID: 30321985Free PMC Article

Clinical prediction guides

Prevalence, Predictors and Point of View Toward Self-Medication Among Residents of Riyadh, Saudi Arabia: A Cross-Sectional Study.
Mannasaheb BA, Alajlan SA, Alshahrani JA, Othman N, Alolayan SO, Alamrah MS, Asdaq SMB, Al-Qahtani AM, Shaikh IA, Alasmary MY
Front Public Health 2022;10:862301. Epub 2022 Mar 25 doi: 10.3389/fpubh.2022.862301. PMID: 35400077Free PMC Article
A prospective study of epidemiology characteristics and outcomes of bloodstream infections in older patients.
Moschou A, Ioannou P, Maraki S, Koutroumpakis F, Mamaloukaki M, Bikis C, Samonis G, Papadakis JA, Kofteridis DP
Australas J Ageing 2021 Sep;40(3):e182-e189. Epub 2020 Nov 10 doi: 10.1111/ajag.12881. PMID: 33174381
A predictive model of inappropriate use of medical tests and medications in Bronchiolitis.
Buendía JA, Rodríguez CA
Pan Afr Med J 2020;37:94. Epub 2020 Sep 25 doi: 10.11604/pamj.2020.37.94.22712. PMID: 33425127Free PMC Article
Clinical symptoms and signs for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community-acquired pneumonia.
Wang K, Gill P, Perera R, Thomson A, Mant D, Harnden A
Cochrane Database Syst Rev 2012 Oct 17;10(10):CD009175. doi: 10.1002/14651858.CD009175.pub2. PMID: 23076954Free PMC Article
Childhood fever.
Chong CY, Allen DM
Singapore Med J 1996 Feb;37(1):96-100. PMID: 8783923

Recent systematic reviews

Clinical symptoms and signs for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community-acquired pneumonia.
Wang K, Gill P, Perera R, Thomson A, Mant D, Harnden A
Cochrane Database Syst Rev 2012 Oct 17;10(10):CD009175. doi: 10.1002/14651858.CD009175.pub2. PMID: 23076954Free PMC Article
Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.
Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, Moll H, Buntinx F, Berger M, Aertgeerts B, Oostenbrink R, Mant D
Health Technol Assess 2012;16(15):1-100. doi: 10.3310/hta16150. PMID: 22452986Free PMC Article

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