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Metastatic Pancreatobiliary Carcinoma

MedGen UID:
1747220
•Concept ID:
C5418564
•
Neoplastic Process

Definition

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555
Differential diagnosis of small solid pancreatic lesions.
Dietrich CF, Sahai AV, D'Onofrio M, Will U, Arcidiacono PG, Petrone MC, Hocke M, Braden B, Burmester E, Möller K, Săftoiu A, Ignee A, Cui XW, Iordache S, Potthoff A, Iglesias-Garcia J, Fusaroli P, Dong Y, Jenssen C
Gastrointest Endosc 2016 Dec;84(6):933-940. Epub 2016 May 4 doi: 10.1016/j.gie.2016.04.034. PMID: 27155592

Recent clinical studies

Etiology

Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience.
Douangprachanh S, Joo HJ, Park HM, Han N, Jang HY, Koh YH, Kim TH, Han SS, Park SJ, Lee WJ, Woo SM, Chun JW
Korean J Intern Med 2022 Nov;37(6):1216-1222. Epub 2022 Nov 1 doi: 10.3904/kjim.2022.100. PMID: 36375489Free PMC Article
Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial.
Mansour A, Mohajeri-Tehrani MR, Samadi M, Qorbani M, Merat S, Adibi H, Poustchi H, Hekmatdoost A
Nutr J 2021 Apr 10;20(1):35. doi: 10.1186/s12937-021-00694-5. PMID: 33838673Free PMC Article
Claudin-18 as a Marker for Identifying the Stomach and Pancreatobiliary Tract as the Primary Sites of Metastatic Adenocarcinoma.
Li WT, Jeng YM, Yang CY
Am J Surg Pathol 2020 Dec;44(12):1643-1648. doi: 10.1097/PAS.0000000000001583. PMID: 32925194
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Biliary carcinogenesis in pancreaticobiliary maljunction.
Kamisawa T, Kuruma S, Chiba K, Tabata T, Koizumi S, Kikuyama M
J Gastroenterol 2017 Feb;52(2):158-163. Epub 2016 Oct 4 doi: 10.1007/s00535-016-1268-z. PMID: 27704265

Diagnosis

Exosomes in hepatocellular carcinoma microenvironment and their potential clinical application value.
He R, Wang Z, Shi W, Yu L, Xia H, Huang Z, Liu S, Zhao X, Xu Y, Yam JWP, Cui Y
Biomed Pharmacother 2021 Jun;138:111529. Epub 2021 Mar 26 doi: 10.1016/j.biopha.2021.111529. PMID: 34311529
Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial.
Mansour A, Mohajeri-Tehrani MR, Samadi M, Qorbani M, Merat S, Adibi H, Poustchi H, Hekmatdoost A
Nutr J 2021 Apr 10;20(1):35. doi: 10.1186/s12937-021-00694-5. PMID: 33838673Free PMC Article
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555
Difficult Diagnostic Problems in Pancreatobiliary Neoplasia.
Bledsoe JR, Shinagare SA, Deshpande V
Arch Pathol Lab Med 2015 Jul;139(7):848-57. doi: 10.5858/arpa.2014-0205-RA. PMID: 26125425
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Therapy

Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis.
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience.
Douangprachanh S, Joo HJ, Park HM, Han N, Jang HY, Koh YH, Kim TH, Han SS, Park SJ, Lee WJ, Woo SM, Chun JW
Korean J Intern Med 2022 Nov;37(6):1216-1222. Epub 2022 Nov 1 doi: 10.3904/kjim.2022.100. PMID: 36375489Free PMC Article
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial.
Mansour A, Mohajeri-Tehrani MR, Samadi M, Qorbani M, Merat S, Adibi H, Poustchi H, Hekmatdoost A
Nutr J 2021 Apr 10;20(1):35. doi: 10.1186/s12937-021-00694-5. PMID: 33838673Free PMC Article
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555

Prognosis

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Exosomes in hepatocellular carcinoma microenvironment and their potential clinical application value.
He R, Wang Z, Shi W, Yu L, Xia H, Huang Z, Liu S, Zhao X, Xu Y, Yam JWP, Cui Y
Biomed Pharmacother 2021 Jun;138:111529. Epub 2021 Mar 26 doi: 10.1016/j.biopha.2021.111529. PMID: 34311529
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555
Mixed adenoneuroendocrine carcinoma of the colon and rectum.
Qiu S, Pellino G, Warren OJ, Mills S, Goldin R, Kontovounisios C, Tekkis PP
Acta Chir Belg 2018 Oct;118(5):273-277. Epub 2018 Jun 17 doi: 10.1080/00015458.2018.1482697. PMID: 29911510
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Clinical prediction guides

Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis.
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Exosomes in hepatocellular carcinoma microenvironment and their potential clinical application value.
He R, Wang Z, Shi W, Yu L, Xia H, Huang Z, Liu S, Zhao X, Xu Y, Yam JWP, Cui Y
Biomed Pharmacother 2021 Jun;138:111529. Epub 2021 Mar 26 doi: 10.1016/j.biopha.2021.111529. PMID: 34311529
The impact of different metastatic patterns on survival in patients with pancreatic cancer.
He C, Huang X, Zhang Y, Lin X, Li S
Pancreatology 2021 Apr;21(3):556-563. Epub 2021 Jan 27 doi: 10.1016/j.pan.2021.01.014. PMID: 33518454
Claudin-18 as a Marker for Identifying the Stomach and Pancreatobiliary Tract as the Primary Sites of Metastatic Adenocarcinoma.
Li WT, Jeng YM, Yang CY
Am J Surg Pathol 2020 Dec;44(12):1643-1648. doi: 10.1097/PAS.0000000000001583. PMID: 32925194
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555

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