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Recurrent Acute Leukemia of Ambiguous Lineage

MedGen UID:
1747716
•Concept ID:
C5419749
•
Neoplastic Process

Definition

The reemergence of acute leukemia of ambiguous lineage after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Leukemia of Ambiguous Lineage

Recent clinical studies

Etiology

Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage.
Montefiori LE, Mullighan CG
Best Pract Res Clin Haematol 2021 Dec;34(4):101329. Epub 2021 Oct 23 doi: 10.1016/j.beha.2021.101329. PMID: 34865701Free PMC Article
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article
Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol.
Wakui M, Kuriyama K, Miyazaki Y, Hata T, Taniwaki M, Ohtake S, Sakamaki H, Miyawaki S, Naoe T, Ohno R, Tomonaga M
Int J Hematol 2008 Mar;87(2):144-151. Epub 2008 Feb 7 doi: 10.1007/s12185-008-0025-3. PMID: 18256787Free PMC Article
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Diagnosis

Genomic Landscape of Mixed-Phenotype Acute Leukemia.
Hennawi M, Pakasticali N, Tashkandi H, Hussaini M
Int J Mol Sci 2022 Sep 24;23(19) doi: 10.3390/ijms231911259. PMID: 36232559Free PMC Article
How I Diagnose Acute Leukemia of Ambiguous Lineage.
Weinberg OK, Arber DA
Am J Clin Pathol 2022 Jul 1;158(1):27-34. doi: 10.1093/ajcp/aqac070. PMID: 35775438
Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage.
Montefiori LE, Mullighan CG
Best Pract Res Clin Haematol 2021 Dec;34(4):101329. Epub 2021 Oct 23 doi: 10.1016/j.beha.2021.101329. PMID: 34865701Free PMC Article
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Therapy

Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome.
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Reduced-toxicity myeloablative conditioning consisting of 8-Gy total body irradiation, cyclophosphamide and fludarabine for pediatric hematological malignancies.
Hirabayashi K, Nakazawa Y, Sakashita K, Kurata T, Saito S, Yoshikawa K, Tanaka M, Yanagisawa R, Koike K
Sci Rep 2014 Nov 6;4:6942. doi: 10.1038/srep06942. PMID: 25373730Free PMC Article

Prognosis

Single-cell analysis of acute lymphoblastic and lineage-ambiguous leukemia: approaches and molecular insights.
Iacobucci I, Witkowski MT, Mullighan CG
Blood 2023 Jan 26;141(4):356-368. doi: 10.1182/blood.2022016954. PMID: 35926109Free PMC Article
Genomic Landscape of Mixed-Phenotype Acute Leukemia.
Hennawi M, Pakasticali N, Tashkandi H, Hussaini M
Int J Mol Sci 2022 Sep 24;23(19) doi: 10.3390/ijms231911259. PMID: 36232559Free PMC Article
Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Clinicopathologic analysis of acute myeloid leukemia in a single institution: biphenotypic acute myeloid leukemia may not be an aggressive subtype.
Lee MY, Tan TD, Feng AC
J Chin Med Assoc 2007 Jul;70(7):269-73. doi: 10.1016/S1726-4901(07)70003-5. PMID: 17631462
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Clinical prediction guides

Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome.
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations.
Bao L, Wang X, Ryder J, Ji M, Chen Y, Chen H, Sun H, Yang Y, Du X, Kerzic P, Gross SA, Yao L, Lv L, Fu H, Lin G, Irons RD
Eur J Haematol 2006 Jul;77(1):35-45. Epub 2006 Mar 27 doi: 10.1111/j.1600-0609.2006.00660.x. PMID: 16573742

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