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Invasive Pancreatic Micropapillary Adenocarcinoma

MedGen UID:
1749373
•Concept ID:
C5419874
•
Neoplastic Process
Synonyms: Pancreatic IMPC; Pancreatic Invasive Micropapillary Adenocarcinoma; Pancreatic Invasive Micropapillary Carcinoma

Definition

An invasive pancreatic ductal adenocarcinoma characterized by the presence of clusters of malignant cells located within artifactual clear stromal spaces. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Pancreatic Micropapillary Adenocarcinoma

Recent clinical studies

Etiology

An S100P-positive biliary epithelial field is a preinvasive intraepithelial neoplasm in nodular-sclerosing cholangiocarcinoma.
Nakanuma Y, Uchida T, Sato Y, Uesaka K
Hum Pathol 2017 Feb;60:46-57. Epub 2016 Oct 28 doi: 10.1016/j.humpath.2016.10.003. PMID: 27984121
BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model.
Alexiev BA, Randhawa P, Vazquez Martul E, Zeng G, Luo C, Ramos E, Drachenberg CB, Papadimitriou JC
Hum Pathol 2013 May;44(5):908-17. Epub 2013 Jan 11 doi: 10.1016/j.humpath.2012.09.019. PMID: 23317548
Pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus.
Huang Q, Gold JS, Shi J, Fan X, Wu H, Feng A, Zhou Q
Hum Pathol 2012 Jun;43(6):911-20. Epub 2011 Nov 4 doi: 10.1016/j.humpath.2011.07.024. PMID: 22055400

Diagnosis

Cytological, histological, and molecular characteristics of pure invasive micropapillary carcinoma of pancreas: A case report.
Lee SJ, Bae HI, Yoon G, Cho CM, Kwon HJ, Park J, Cho SH, Seo AN
Medicine (Baltimore) 2020 Jun 12;99(24):e20668. doi: 10.1097/MD.0000000000020668. PMID: 32541511Free PMC Article
Intraductal neoplasms of the bile duct. A new challenge to biliary tract tumor pathology.
Nakanuma Y, Uesaka K, Miyayama S, Yamaguchi H, Ohtsuka M
Histol Histopathol 2017 Oct;32(10):1001-1015. Epub 2017 Mar 24 doi: 10.14670/HH-11-892. PMID: 28337739
An S100P-positive biliary epithelial field is a preinvasive intraepithelial neoplasm in nodular-sclerosing cholangiocarcinoma.
Nakanuma Y, Uchida T, Sato Y, Uesaka K
Hum Pathol 2017 Feb;60:46-57. Epub 2016 Oct 28 doi: 10.1016/j.humpath.2016.10.003. PMID: 27984121
Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract.
Guzińska-Ustymowicz K, Niewiarowska K, Pryczynicz A
World J Gastroenterol 2014 Apr 28;20(16):4597-606. doi: 10.3748/wjg.v20.i16.4597. PMID: 24782612Free PMC Article
BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model.
Alexiev BA, Randhawa P, Vazquez Martul E, Zeng G, Luo C, Ramos E, Drachenberg CB, Papadimitriou JC
Hum Pathol 2013 May;44(5):908-17. Epub 2013 Jan 11 doi: 10.1016/j.humpath.2012.09.019. PMID: 23317548

Therapy

BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model.
Alexiev BA, Randhawa P, Vazquez Martul E, Zeng G, Luo C, Ramos E, Drachenberg CB, Papadimitriou JC
Hum Pathol 2013 May;44(5):908-17. Epub 2013 Jan 11 doi: 10.1016/j.humpath.2012.09.019. PMID: 23317548
Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors.
Gaida MM, Steffen TG, Günther F, Tschaharganeh DF, Felix K, Bergmann F, Schirmacher P, Hänsch GM
Eur J Immunol 2012 Dec;42(12):3369-80. Epub 2012 Nov 2 doi: 10.1002/eji.201242628. PMID: 23001948

Prognosis

Cytological, histological, and molecular characteristics of pure invasive micropapillary carcinoma of pancreas: A case report.
Lee SJ, Bae HI, Yoon G, Cho CM, Kwon HJ, Park J, Cho SH, Seo AN
Medicine (Baltimore) 2020 Jun 12;99(24):e20668. doi: 10.1097/MD.0000000000020668. PMID: 32541511Free PMC Article
Pure invasive micropapillary carcinoma of the esophagogastric junction with lymph nodes and liver metastasis.
Hattori T, Sentani K, Hattori Y, Oue N, Yasui W
Pathol Int 2016 Oct;66(10):583-586. Epub 2016 Aug 24 doi: 10.1111/pin.12450. PMID: 27553658
Mucinous micropapillary pattern in lung adenocarcinomas: a unique histology with genetic correlates.
Kamata T, Yoshida A, Shiraishi K, Furuta K, Kosuge T, Watanabe S, Asamura H, Tsuta K
Histopathology 2016 Feb;68(3):356-66. Epub 2015 Aug 7 doi: 10.1111/his.12763. PMID: 26109197
Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract.
Guzińska-Ustymowicz K, Niewiarowska K, Pryczynicz A
World J Gastroenterol 2014 Apr 28;20(16):4597-606. doi: 10.3748/wjg.v20.i16.4597. PMID: 24782612Free PMC Article
Tumor-infiltrating neutrophils in pancreatic neoplasia.
Reid MD, Basturk O, Thirabanjasak D, Hruban RH, Klimstra DS, Bagci P, Altinel D, Adsay V
Mod Pathol 2011 Dec;24(12):1612-9. Epub 2011 Aug 5 doi: 10.1038/modpathol.2011.113. PMID: 21822201Free PMC Article

Clinical prediction guides

An S100P-positive biliary epithelial field is a preinvasive intraepithelial neoplasm in nodular-sclerosing cholangiocarcinoma.
Nakanuma Y, Uchida T, Sato Y, Uesaka K
Hum Pathol 2017 Feb;60:46-57. Epub 2016 Oct 28 doi: 10.1016/j.humpath.2016.10.003. PMID: 27984121
Invasive micropapillary carcinoma: a distinct type of adenocarcinomas in the gastrointestinal tract.
Guzińska-Ustymowicz K, Niewiarowska K, Pryczynicz A
World J Gastroenterol 2014 Apr 28;20(16):4597-606. doi: 10.3748/wjg.v20.i16.4597. PMID: 24782612Free PMC Article
Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms.
Sato Y, Harada K, Sasaki M, Nakanuma Y
Virchows Arch 2014 Feb;464(2):157-63. Epub 2014 Jan 24 doi: 10.1007/s00428-014-1537-2. PMID: 24458517
BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model.
Alexiev BA, Randhawa P, Vazquez Martul E, Zeng G, Luo C, Ramos E, Drachenberg CB, Papadimitriou JC
Hum Pathol 2013 May;44(5):908-17. Epub 2013 Jan 11 doi: 10.1016/j.humpath.2012.09.019. PMID: 23317548
Prognostic value of the IASLC/ATS/ERS classification of lung adenocarcinoma in stage I disease of Japanese cases.
Woo T, Okudela K, Mitsui H, Tajiri M, Yamamoto T, Rino Y, Ohashi K, Masuda M
Pathol Int 2012 Dec;62(12):785-91. doi: 10.1111/pin.12016. PMID: 23252867

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