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Refractory Acute Leukemia of Ambiguous Lineage

MedGen UID:
1751423
•Concept ID:
C5419751
•
Neoplastic Process

Definition

Acute leukemia of ambiguous lineage that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Acute Leukemia of Ambiguous Lineage

Professional guidelines

PubMed

Treatment of blastic plasmacytoid dendritic cell neoplasm.
Sullivan JM, Rizzieri DA
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):16-23. doi: 10.1182/asheducation-2016.1.16. PMID: 27913457Free PMC Article

Recent clinical studies

Etiology

Acute leukemia with cytogenetically cryptic FGFR1 rearrangement and lineage switch during therapy: A case report and literature review.
McKeague SJ, O'Rourke K, Fanning S, Joy C, Throp D, Adams R, Harvey Y, Keng TB
Am J Clin Pathol 2024 Feb 1;161(2):197-205. doi: 10.1093/ajcp/aqad135. PMID: 37855739
Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article

Diagnosis

Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Diagnostic approach to the evaluation of myeloid malignancies following CAR T-cell therapy in B-cell acute lymphoblastic leukemia.
Mo G, Wang HW, Talleur AC, Shahani SA, Yates B, Shalabi H, Douvas MG, Calvo KR, Shern JF, Chaganti S, Patrick K, Song Y, Fry TJ, Wu X, Triplett BM, Khan J, Gardner RA, Shah NN
J Immunother Cancer 2020 Nov;8(2) doi: 10.1136/jitc-2020-001563. PMID: 33246985Free PMC Article
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome.
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681

Therapy

Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome.
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681
Treatment of blastic plasmacytoid dendritic cell neoplasm.
Sullivan JM, Rizzieri DA
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):16-23. doi: 10.1182/asheducation-2016.1.16. PMID: 27913457Free PMC Article

Prognosis

Acute leukemia with cytogenetically cryptic FGFR1 rearrangement and lineage switch during therapy: A case report and literature review.
McKeague SJ, O'Rourke K, Fanning S, Joy C, Throp D, Adams R, Harvey Y, Keng TB
Am J Clin Pathol 2024 Feb 1;161(2):197-205. doi: 10.1093/ajcp/aqad135. PMID: 37855739
Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726

Clinical prediction guides

Predictive Factors and Outcomes after Allogeneic Stem Cell Transplantation for Adults with Acute Lymphoblastic Leukemia in Brazil.
Silva WF, Cysne DN, Kerbauy MN, Colturato I, Maia ACA, Tucunduva L, Barros GMN, Colturato VAR, Hamerschlak N, Rocha V
Transplant Cell Ther 2022 Nov;28(11):763.e1-763.e7. Epub 2022 Jul 30 doi: 10.1016/j.jtct.2022.07.025. PMID: 35914726
Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study.
Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE
Lancet Oncol 2020 Apr;21(4):551-560. Epub 2020 Mar 11 doi: 10.1016/S1470-2045(20)30060-7. PMID: 32171069Free PMC Article
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome.
Kurt H, Zheng L, Kantarjian HM, Tang G, Ravandi-Kashani F, Garcia-Manero G, Gong Z, Amin HM, Konoplev SN, Routbort MJ, Han X, Wang W, Medeiros LJ, Hu S
Mod Pathol 2018 Jul;31(7):1141-1154. Epub 2018 Feb 14 doi: 10.1038/s41379-018-0014-x. PMID: 29449681

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