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Overt Stroke

MedGen UID:
1754069
•Concept ID:
C5400991
•
Disease or Syndrome
Synonym: Overt Cerebral Infarction

Definition

A cerebral infarction that is evident by new neurological symptoms lasting greater than 24 hours or having an area of diffusion restriction or a T2 or fluid-attenuated inversion recovery (FLAIR) hyperintensity on an MRI of the brain that was consistent with the neurological findings. [from NCI]

Professional guidelines

PubMed

Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease.
Mack AK, Thompson AA
J Pediatr Health Care 2017 Mar-Apr;31(2):145-154. Epub 2016 Jul 14 doi: 10.1016/j.pedhc.2016.06.005. PMID: 27423528
Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
Wang WC, Dwan K
Cochrane Database Syst Rev 2013 Nov 14;(11):CD003146. doi: 10.1002/14651858.CD003146.pub2. PMID: 24226646Free PMC Article
Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management.
Black SE
J R Coll Physicians Edinb 2011 Mar;41(1):49-56. doi: 10.4997/JRCPE.2011.121. PMID: 21365068

Recent clinical studies

Etiology

The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.
Ramos K, Guilliams KP, Fields ME
Hematol Oncol Clin North Am 2022 Dec;36(6):1167-1186. doi: 10.1016/j.hoc.2022.07.011. PMID: 36400537Free PMC Article
Sickle Cell Disease and Stroke.
Hirtz D, Kirkham FJ
Pediatr Neurol 2019 Jun;95:34-41. Epub 2019 Feb 27 doi: 10.1016/j.pediatrneurol.2019.02.018. PMID: 30948147
Neuroprotective measures throughout the TAVI pathway.
Shiyovich A, Kornowski R
Minerva Cardioangiol 2019 Feb;67(1):39-56. Epub 2018 Jul 17 doi: 10.23736/S0026-4725.18.04763-1. PMID: 30014679
Dementia and Atrial Fibrillation: Pathophysiological Mechanisms and Therapeutic Implications.
Chopard R, Piazza G, Gale SA, Campia U, Albertsen IE, Kim J, Goldhaber SZ
Am J Med 2018 Dec;131(12):1408-1417. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.06.035. PMID: 30076825
Sickle cell disease.
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Diagnosis

Sickle Cell Disease and Stroke.
Hirtz D, Kirkham FJ
Pediatr Neurol 2019 Jun;95:34-41. Epub 2019 Feb 27 doi: 10.1016/j.pediatrneurol.2019.02.018. PMID: 30948147
Neuroprotective measures throughout the TAVI pathway.
Shiyovich A, Kornowski R
Minerva Cardioangiol 2019 Feb;67(1):39-56. Epub 2018 Jul 17 doi: 10.23736/S0026-4725.18.04763-1. PMID: 30014679
Sickle cell disease in childhood: from newborn screening through transition to adult medical care.
Quinn CT
Pediatr Clin North Am 2013 Dec;60(6):1363-81. doi: 10.1016/j.pcl.2013.09.006. PMID: 24237976Free PMC Article
Silent brain infarction--a review of recent observations.
Kovács KR, Czuriga D, Bereczki D, Bornstein NM, Csiba L
Int J Stroke 2013 Jul;8(5):334-47. Epub 2012 Aug 1 doi: 10.1111/j.1747-4949.2012.00851.x. PMID: 22863197
Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management.
Black SE
J R Coll Physicians Edinb 2011 Mar;41(1):49-56. doi: 10.4997/JRCPE.2011.121. PMID: 21365068

Therapy

Stroke in sickle cell disease and the promise of recent disease modifying agents.
Runge A, Brazel D, Pakbaz Z
J Neurol Sci 2022 Nov 15;442:120412. Epub 2022 Sep 9 doi: 10.1016/j.jns.2022.120412. PMID: 36150233
Sickle Cell Disease and Stroke.
Hirtz D, Kirkham FJ
Pediatr Neurol 2019 Jun;95:34-41. Epub 2019 Feb 27 doi: 10.1016/j.pediatrneurol.2019.02.018. PMID: 30948147
Neuroprotective measures throughout the TAVI pathway.
Shiyovich A, Kornowski R
Minerva Cardioangiol 2019 Feb;67(1):39-56. Epub 2018 Jul 17 doi: 10.23736/S0026-4725.18.04763-1. PMID: 30014679
Dementia and Atrial Fibrillation: Pathophysiological Mechanisms and Therapeutic Implications.
Chopard R, Piazza G, Gale SA, Campia U, Albertsen IE, Kim J, Goldhaber SZ
Am J Med 2018 Dec;131(12):1408-1417. Epub 2018 Aug 1 doi: 10.1016/j.amjmed.2018.06.035. PMID: 30076825
Mechanisms, Clinical Significance, and Prevention of Cognitive Impairment in Patients With Atrial Fibrillation.
Rivard L, Khairy P
Can J Cardiol 2017 Dec;33(12):1556-1564. Epub 2017 Oct 6 doi: 10.1016/j.cjca.2017.09.024. PMID: 29173598

Prognosis

The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.
Ramos K, Guilliams KP, Fields ME
Hematol Oncol Clin North Am 2022 Dec;36(6):1167-1186. doi: 10.1016/j.hoc.2022.07.011. PMID: 36400537Free PMC Article
Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management.
Black SE
J R Coll Physicians Edinb 2011 Mar;41(1):49-56. doi: 10.4997/JRCPE.2011.121. PMID: 21365068
Genetic modifiers of the beta-haemoglobinopathies.
Thein SL
Br J Haematol 2008 May;141(3):357-66. doi: 10.1111/j.1365-2141.2008.07084.x. PMID: 18410570
Management of temperature during and after cardiac surgery.
Nussmeier NA
Tex Heart Inst J 2005;32(4):472-6. PMID: 16429889Free PMC Article
Sickle cell disease.
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Clinical prediction guides

The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.
Ramos K, Guilliams KP, Fields ME
Hematol Oncol Clin North Am 2022 Dec;36(6):1167-1186. doi: 10.1016/j.hoc.2022.07.011. PMID: 36400537Free PMC Article
Silent brain infarction--a review of recent observations.
Kovács KR, Czuriga D, Bereczki D, Bornstein NM, Csiba L
Int J Stroke 2013 Jul;8(5):334-47. Epub 2012 Aug 1 doi: 10.1111/j.1747-4949.2012.00851.x. PMID: 22863197
Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management.
Black SE
J R Coll Physicians Edinb 2011 Mar;41(1):49-56. doi: 10.4997/JRCPE.2011.121. PMID: 21365068
Genetic modifiers of the beta-haemoglobinopathies.
Thein SL
Br J Haematol 2008 May;141(3):357-66. doi: 10.1111/j.1365-2141.2008.07084.x. PMID: 18410570
Sickle cell disease.
Buchanan GR, DeBaun MR, Quinn CT, Steinberg MH
Hematology Am Soc Hematol Educ Program 2004:35-47. doi: 10.1182/asheducation-2004.1.35. PMID: 15561675

Recent systematic reviews

Burden of central nervous system complications in sickle cell disease: A systematic review and meta-analysis.
Lee S, Lucas S, Proudman D, Nellesen D, Paulose J, Sheehan VA
Pediatr Blood Cancer 2022 Apr;69(4):e29493. Epub 2022 Jan 17 doi: 10.1002/pbc.29493. PMID: 35038214
A systematic review of the literature for severity predictors in children with sickle cell anemia.
Meier ER, Fasano RM, Levett PR
Blood Cells Mol Dis 2017 Jun;65:86-94. Epub 2017 Feb 2 doi: 10.1016/j.bcmd.2017.01.014. PMID: 28185829
Neurological Outcomes With Embolic Protection Devices in Patients Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Giustino G, Mehran R, Veltkamp R, Faggioni M, Baber U, Dangas GD
JACC Cardiovasc Interv 2016 Oct 24;9(20):2124-2133. doi: 10.1016/j.jcin.2016.07.024. PMID: 27765306
Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.
Lance EI, Casella JF, Everett AD, Barron-Casella E
Proteomics Clin Appl 2014 Dec;8(11-12):813-27. Epub 2014 Nov 6 doi: 10.1002/prca.201400069. PMID: 25290359Free PMC Article
Silent brain infarcts: a systematic review.
Vermeer SE, Longstreth WT Jr, Koudstaal PJ
Lancet Neurol 2007 Jul;6(7):611-9. doi: 10.1016/S1474-4422(07)70170-9. PMID: 17582361

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