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Metastatic Anal Carcinoma

MedGen UID:
1755103
•Concept ID:
C5401417
•
Neoplastic Process

Definition

Anal carcinoma that has spread from its primary site to another anatomic site. [from NCI]

Professional guidelines

PubMed

Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, Grem JL, Hecht JR, Hoffe S, Hubbard J, Hunt S, Hussan H, Jeck W, Johung KL, Joseph N, Kirilcuk N, Krishnamurthi S, Maratt J, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen K, Saltz L, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stotsky-Himelfarb E, Tavakkoli A, Willett CG, Williams G, Algieri F, Gurski L, Stehman K
J Natl Compr Canc Netw 2023 Jun;21(6):653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125
Platinum-Fluoropyrimidine and Paclitaxel-Based Chemotherapy in the Treatment of Advanced Anal Cancer Patients.
Sclafani F, Morano F, Cunningham D, Baratelli C, Kalaitzaki E, Watkins D, Starling N, Chau I, Rao S
Oncologist 2017 Apr;22(4):402-408. Epub 2017 Feb 16 doi: 10.1634/theoncologist.2016-0241. PMID: 28209745Free PMC Article
Treatment options in metastatic squamous cell carcinoma of the anal canal.
Eng C, Pathak P
Curr Treat Options Oncol 2008 Dec;9(4-6):400-7. Epub 2009 May 29 doi: 10.1007/s11864-009-0103-7. PMID: 19479383

Recent clinical studies

Etiology

Relapsed refractory metastatic squamous cell cancer of anal canal in a patient with retroviral infection responding to cetuximab.
Lerner J, Michel M, Dasanu CA
J Oncol Pharm Pract 2020 Jun;26(4):1025-1028. Epub 2019 Nov 4 doi: 10.1177/1078155219884605. PMID: 31684821
Does gap-free intensity modulated chemoradiation therapy provide a greater clinical benefit than 3D conformal chemoradiation in patients with anal cancer?
Dewas CV, Maingon P, Dalban C, Petitfils A, Peignaux K, Truc G, Martin E, Khoury C, Dewas S, Créhange G
Radiat Oncol 2012 Nov 29;7:201. doi: 10.1186/1748-717X-7-201. PMID: 23190693Free PMC Article

Diagnosis

Combined multimodal approach to the treatment of metastatic anal carcinoma: report of a case and review of the literature.
Tokar M, Bobilev D, Zalmanov S, Geffen DB, Walfisch S
Onkologie 2006 Feb;29(1-2):30-2. doi: 10.1159/000089798. PMID: 16514253

Therapy

Relapsed refractory metastatic squamous cell cancer of anal canal in a patient with retroviral infection responding to cetuximab.
Lerner J, Michel M, Dasanu CA
J Oncol Pharm Pract 2020 Jun;26(4):1025-1028. Epub 2019 Nov 4 doi: 10.1177/1078155219884605. PMID: 31684821
Platinum-Fluoropyrimidine and Paclitaxel-Based Chemotherapy in the Treatment of Advanced Anal Cancer Patients.
Sclafani F, Morano F, Cunningham D, Baratelli C, Kalaitzaki E, Watkins D, Starling N, Chau I, Rao S
Oncologist 2017 Apr;22(4):402-408. Epub 2017 Feb 16 doi: 10.1634/theoncologist.2016-0241. PMID: 28209745Free PMC Article
Treatment options in metastatic squamous cell carcinoma of the anal canal.
Eng C, Pathak P
Curr Treat Options Oncol 2008 Dec;9(4-6):400-7. Epub 2009 May 29 doi: 10.1007/s11864-009-0103-7. PMID: 19479383
Combined multimodal approach to the treatment of metastatic anal carcinoma: report of a case and review of the literature.
Tokar M, Bobilev D, Zalmanov S, Geffen DB, Walfisch S
Onkologie 2006 Feb;29(1-2):30-2. doi: 10.1159/000089798. PMID: 16514253
Response of metastatic anal carcinoma to single agent carboplatin.
Evans TR, Mansi JL, Glees JP
Clin Oncol (R Coll Radiol) 1993;5(1):57-8. doi: 10.1016/s0936-6555(05)80699-5. PMID: 8424915

Prognosis

Relapsed refractory metastatic squamous cell cancer of anal canal in a patient with retroviral infection responding to cetuximab.
Lerner J, Michel M, Dasanu CA
J Oncol Pharm Pract 2020 Jun;26(4):1025-1028. Epub 2019 Nov 4 doi: 10.1177/1078155219884605. PMID: 31684821
Platinum-Fluoropyrimidine and Paclitaxel-Based Chemotherapy in the Treatment of Advanced Anal Cancer Patients.
Sclafani F, Morano F, Cunningham D, Baratelli C, Kalaitzaki E, Watkins D, Starling N, Chau I, Rao S
Oncologist 2017 Apr;22(4):402-408. Epub 2017 Feb 16 doi: 10.1634/theoncologist.2016-0241. PMID: 28209745Free PMC Article
Does gap-free intensity modulated chemoradiation therapy provide a greater clinical benefit than 3D conformal chemoradiation in patients with anal cancer?
Dewas CV, Maingon P, Dalban C, Petitfils A, Peignaux K, Truc G, Martin E, Khoury C, Dewas S, Créhange G
Radiat Oncol 2012 Nov 29;7:201. doi: 10.1186/1748-717X-7-201. PMID: 23190693Free PMC Article
Treatment options in metastatic squamous cell carcinoma of the anal canal.
Eng C, Pathak P
Curr Treat Options Oncol 2008 Dec;9(4-6):400-7. Epub 2009 May 29 doi: 10.1007/s11864-009-0103-7. PMID: 19479383

Clinical prediction guides

Platinum-Fluoropyrimidine and Paclitaxel-Based Chemotherapy in the Treatment of Advanced Anal Cancer Patients.
Sclafani F, Morano F, Cunningham D, Baratelli C, Kalaitzaki E, Watkins D, Starling N, Chau I, Rao S
Oncologist 2017 Apr;22(4):402-408. Epub 2017 Feb 16 doi: 10.1634/theoncologist.2016-0241. PMID: 28209745Free PMC Article

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