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Digestive System Inflammatory Myofibroblastic Tumor

MedGen UID:
1755929
•Concept ID:
C5419898
•
Neoplastic Process

Definition

A multinodular intermediate fibroblastic neoplasm arising from the digestive system. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDigestive System Inflammatory Myofibroblastic Tumor

Professional guidelines

PubMed

Hepatic inflammatory pseudotumor mimicking malignancy: the value of differential diagnosis on contrast enhanced ultrasound.
Kong WT, Wang WP, Shen HY, Xue HY, Liu CR, Huang DQ, Wu M
Med Ultrason 2021 Feb 18;23(1):15-21. Epub 2020 Aug 18 doi: 10.11152/mu-2542. PMID: 32905565
Endoscopic ultrasound and fine needle aspiration in chronic pancreatitis: differential diagnosis between pseudotumoral masses and pancreatic cancer.
Ardengh JC, Lopes CV, Campos AD, Pereira de Lima LF, Venco F, Módena JL
JOP 2007 Jul 9;8(4):413-21. PMID: 17625292
Intestinal invagination in adults: preoperative diagnosis and management.
Martín-Lorenzo JG, Torralba-Martinez A, Lirón-Ruiz R, Flores-Pastor B, Miguel-Perelló J, Aguilar-Jimenez J, Aguayo-Albasini JL
Int J Colorectal Dis 2004 Jan;19(1):68-72. Epub 2003 Jun 28 doi: 10.1007/s00384-003-0514-z. PMID: 12838363

Recent clinical studies

Etiology

Paediatric Gastrointestinal, Hepatic and Pancreatic Inflammatory Myofibroblastic Tumours, A Single Centre Experience.
Couper MR, Eldredge JA, Kirby M, Kirby C, Moore D, Hammond P, Manton N, Glynn A, Couper RT
J Pediatr Gastroenterol Nutr 2022 Feb 1;74(2):253-257. doi: 10.1097/MPG.0000000000003311. PMID: 34596604
Fibrohistiocytic Variant of Hepatic Pseudotumor: An Antibiotic Responsive Tumefactive Lesion.
Arora KS, Anderson MA, Neyaz A, Yilmaz O, Pankaj A, Ferrone CR, Zen Y, England J, Deshpande V
Am J Surg Pathol 2021 Oct 1;45(10):1314-1323. doi: 10.1097/PAS.0000000000001767. PMID: 34334689
Differentiation between inflammatory myofibroblastic tumor and cholangiocarcinoma manifesting as target appearance on gadoxetic acid-enhanced MRI.
Chang AI, Kim YK, Min JH, Lee J, Kim H, Lee SJ
Abdom Radiol (NY) 2019 Apr;44(4):1395-1406. doi: 10.1007/s00261-018-1847-y. PMID: 30515535
Cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal neoplasms occurring in the gastrointestinal tract.
Ieni A, Barresi V, Reggiani Bonetti L, Branca G, Caruso RA, Tuccari G
Scand J Gastroenterol 2017 Mar;52(3):291-299. Epub 2016 Nov 6 doi: 10.1080/00365521.2016.1251607. PMID: 27817254
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Diagnosis

Rectal inflammatory myofibroblastic tumor: Case report and literature review.
Oh HH, Joo YE
Medicine (Baltimore) 2021 Aug 20;100(33):e27008. doi: 10.1097/MD.0000000000027008. PMID: 34414993Free PMC Article
Immunoglobulin G4-related hepatobiliary disease.
Lee HE, Zhang L
Semin Diagn Pathol 2019 Nov;36(6):423-433. Epub 2019 Jul 24 doi: 10.1053/j.semdp.2019.07.007. PMID: 31358425
Inflammatory myofibroblastic tumor of the gallbladder: a case report and literature review.
Yamada T, Hisa T, Shiozawa S, Kudo A, Furukawa R
J Med Ultrason (2001) 2018 Jan;45(1):175-180. Epub 2017 Jun 21 doi: 10.1007/s10396-017-0798-1. PMID: 28639154
Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY
World J Gastroenterol 2014 Oct 7;20(37):13625-31. doi: 10.3748/wjg.v20.i37.13625. PMID: 25309095Free PMC Article
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Therapy

Fibrohistiocytic Variant of Hepatic Pseudotumor: An Antibiotic Responsive Tumefactive Lesion.
Arora KS, Anderson MA, Neyaz A, Yilmaz O, Pankaj A, Ferrone CR, Zen Y, England J, Deshpande V
Am J Surg Pathol 2021 Oct 1;45(10):1314-1323. doi: 10.1097/PAS.0000000000001767. PMID: 34334689
Lipopolysaccharide Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against Decapentaplegic, and CCAAT/Enhancer-Binding Protein C/EBP Transcription Factors.
Sharma A, Verma AK, Kofron M, Kudira R, Miethke A, Wu T, Wang J, Gandhi CR
Hepatology 2020 Nov;72(5):1800-1818. Epub 2020 Oct 22 doi: 10.1002/hep.31188. PMID: 32064648Free PMC Article
Posttransplant epithelioid inflammatory myofibroblastic sarcoma: A case report.
Garg R, Kaul S, Arora D, Kashyap V
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):303-305. doi: 10.4103/IJPM.IJPM_284_17. PMID: 30971562
Hepatic actinomycosis with immunoglobulin G4-related liver disease: A case report.
Lee JH, Kim HS, Kim JS, Lee DK, Lim JH
Medicine (Baltimore) 2018 Jun;97(24):e11146. doi: 10.1097/MD.0000000000011146. PMID: 29901644Free PMC Article
Inflammatory myofibroblastic tumor of the midesophagus.
Goldin SB, Osborne D, Paidas C, Iannello J, Gilbert-Barness E, Karl R, Wilsey MJ Jr
Fetal Pediatr Pathol 2007 Sep-Dec;26(5-6):243-54. doi: 10.1080/15513810801893421. PMID: 18363157

Prognosis

Gastric and cardiac inflammatory myofibroblastic tumor: an extremely rare case.
Huang Y, Zhang M, Li Q, Huang Q
J Cardiothorac Surg 2024 Jan 29;19(1):31. doi: 10.1186/s13019-024-02481-9. PMID: 38287440Free PMC Article
ROS1-positive Inflammatory Myofibroblastic Tumor of the Small Bowel Causing Obstruction: A Case Report.
Budylev A, Solar I, Kessner R, Aizic A
J Radiol Case Rep 2022 Jan;16(1):14-21. Epub 2022 Jan 1 doi: 10.3941/jrcr.v16i1.3928. PMID: 35586084Free PMC Article
Paediatric Gastrointestinal, Hepatic and Pancreatic Inflammatory Myofibroblastic Tumours, A Single Centre Experience.
Couper MR, Eldredge JA, Kirby M, Kirby C, Moore D, Hammond P, Manton N, Glynn A, Couper RT
J Pediatr Gastroenterol Nutr 2022 Feb 1;74(2):253-257. doi: 10.1097/MPG.0000000000003311. PMID: 34596604
Inflammatory myofibroblastic tumor of the small intestine mimicking acute appendicitis: a case report and review of the literature.
Oeconomopoulou A, de Verney Y, Kanavaki K, Stefanaki K, Pavlakis K, Salakos C
J Med Case Rep 2016 Apr 19;10:100. doi: 10.1186/s13256-016-0880-0. PMID: 27094797Free PMC Article
Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY
World J Gastroenterol 2014 Oct 7;20(37):13625-31. doi: 10.3748/wjg.v20.i37.13625. PMID: 25309095Free PMC Article

Clinical prediction guides

Gastric and cardiac inflammatory myofibroblastic tumor: an extremely rare case.
Huang Y, Zhang M, Li Q, Huang Q
J Cardiothorac Surg 2024 Jan 29;19(1):31. doi: 10.1186/s13019-024-02481-9. PMID: 38287440Free PMC Article
Clinical and Pathological Features of Immune Checkpoint Inhibitor-induced Liver Injury in Comparison with Drug-induced Liver Injury and Autoimmune Hepatitis.
Sunago K, Abe M, Yoshida O, Watanabe T, Nakamura Y, Imai Y, Koizumi Y, Hirooka M, Tokumoto Y, Hiasa Y
J Gastrointestin Liver Dis 2023 Dec 22;32(4):488-496. doi: 10.15403/jgld-5045. PMID: 38147620
Fibrohistiocytic Variant of Hepatic Pseudotumor: An Antibiotic Responsive Tumefactive Lesion.
Arora KS, Anderson MA, Neyaz A, Yilmaz O, Pankaj A, Ferrone CR, Zen Y, England J, Deshpande V
Am J Surg Pathol 2021 Oct 1;45(10):1314-1323. doi: 10.1097/PAS.0000000000001767. PMID: 34334689
Differentiation between inflammatory myofibroblastic tumor and cholangiocarcinoma manifesting as target appearance on gadoxetic acid-enhanced MRI.
Chang AI, Kim YK, Min JH, Lee J, Kim H, Lee SJ
Abdom Radiol (NY) 2019 Apr;44(4):1395-1406. doi: 10.1007/s00261-018-1847-y. PMID: 30515535
Intra-abdominal inflammatory myofibroblastic tumor: spontaneous regression.
Zhao JJ, Ling JQ, Fang Y, Gao XD, Shu P, Shen KT, Qin J, Sun YH, Qin XY
World J Gastroenterol 2014 Oct 7;20(37):13625-31. doi: 10.3748/wjg.v20.i37.13625. PMID: 25309095Free PMC Article

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