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Abnormal TSH response to thyrotrophin-releasing hormone stimulation test

MedGen UID:
1757761
•Concept ID:
C5421594
•
Finding
Synonym: Abnormal TSH response to TRH stimulation test
 
HPO: HP:0033080

Definition

Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide synthesized by, stored within, and released from the hypothalamus. It stimulates the synthesis and release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. Following administration of exogenous TRH, a transient increase in serum TSH is expected. This term refers to an abnormal response in the TRH stimulation test. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal TSH response to thyrotrophin-releasing hormone stimulation test

Professional guidelines

PubMed

Catecholamines and pituitary function. IV. Effects of low-dose dopamine infusion and long-term bromocriptine treatment on the abnormal thyrotroph (TSH) dynamics in patients with pathological hyperprolactinaemia.
Nicoletti I, Filipponi P, Fedeli L, Ambrosi F, Giammartino C, Spinozzi F, Santeusanio F
Acta Endocrinol (Copenh) 1986 Feb;111(2):154-61. doi: 10.1530/acta.0.1110154. PMID: 3082094
The dexamethasone suppression and thyrotropin-releasing hormone tests and response to treatment in unipolar depression.
Extein I, Kirstein LS, Pottash AL, Gold MS
Int J Psychiatry Med 1982-1983;12(4):267-74. doi: 10.2190/a6le-qva9-1ll1-xv49. PMID: 6820012

Recent clinical studies

Etiology

Relationship between chronobiological thyrotropin and prolactin responses to protirelin (TRH) and suicidal behavior in depressed patients.
Duval F, Mokrani MC, Erb A, Gonzalez Opera F, Calleja C, Paris V
Psychoneuroendocrinology 2017 Nov;85:100-109. Epub 2017 Jul 28 doi: 10.1016/j.psyneuen.2017.07.488. PMID: 28843902
Role of the thyrotropin-releasing hormone stimulation test in diagnosis of congenital central hypothyroidism in infants.
van Tijn DA, de Vijlder JJ, Vulsma T
J Clin Endocrinol Metab 2008 Feb;93(2):410-9. Epub 2007 Nov 13 doi: 10.1210/jc.2006-2656. PMID: 18000095
The TRH stimulation test and reverse T3 in depression.
Sternbach HA, Gwirtsman HE, Gerner RH, Hershman J, Pekary E
J Affect Disord 1985 May-Jun;8(3):267-70. doi: 10.1016/0165-0327(85)90025-4. PMID: 3160737
Violent suicidal behavior and the thyrotropin-releasing hormone-thyroid-stimulating hormone test: a clinical outcome study.
Linkowski P, Van Wettere JP, Kerkhofs M, Gregoire F, Brauman H, Mendlewicz J
Neuropsychobiology 1984;12(1):19-22. doi: 10.1159/000118104. PMID: 6440049
Abnormal TSH, PRL and GH response to TSH releasing factor in chronic renal failure.
Czernichow P, Dauzet MC, Broyer M, Rappaport R
J Clin Endocrinol Metab 1976 Sep;43(3):630-7. doi: 10.1210/jcem-43-3-630. PMID: 821962

Diagnosis

Role of the thyrotropin-releasing hormone stimulation test in diagnosis of congenital central hypothyroidism in infants.
van Tijn DA, de Vijlder JJ, Vulsma T
J Clin Endocrinol Metab 2008 Feb;93(2):410-9. Epub 2007 Nov 13 doi: 10.1210/jc.2006-2656. PMID: 18000095
TRH stimulation test in healthy elderly: paradoxical response of growth hormone is abnormal in normal aging.
Ohbu S, Yoshioka N, Honda M, Andoh Y, Sato Y, Takao N, Fukuda H, Wakayama Y
Intern Med 1995 Mar;34(3):148-52. doi: 10.2169/internalmedicine.34.148. PMID: 7787317
The TRH stimulation test and reverse T3 in depression.
Sternbach HA, Gwirtsman HE, Gerner RH, Hershman J, Pekary E
J Affect Disord 1985 May-Jun;8(3):267-70. doi: 10.1016/0165-0327(85)90025-4. PMID: 3160737
The Prader-Willi syndrome: a study of 40 patients and a review of the literature.
Bray GA, Dahms WT, Swerdloff RS, Fiser RH, Atkinson RL, Carrel RE
Medicine (Baltimore) 1983 Mar;62(2):59-80. PMID: 6338343
Abnormal TSH, PRL and GH response to TSH releasing factor in chronic renal failure.
Czernichow P, Dauzet MC, Broyer M, Rappaport R
J Clin Endocrinol Metab 1976 Sep;43(3):630-7. doi: 10.1210/jcem-43-3-630. PMID: 821962

Therapy

Subclinical hypothyroidism in infertile women: the importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test.
Eldar-Geva T, Shoham M, Rösler A, Margalioth EJ, Livne K, Meirow D
Gynecol Endocrinol 2007 Jun;23(6):332-7. doi: 10.1080/09513590701267651. PMID: 17616857
Effects of antidepressant treatment on thyrotropin-releasing hormone stimulation, growth hormone response to L-DOPA, and dexamethasone suppression tests in major depressive patients.
Esel E, Kartalci S, Tutus A, Turan T, Sofuoglu S
Prog Neuropsychopharmacol Biol Psychiatry 2004 Mar;28(2):303-9. doi: 10.1016/j.pnpbp.2003.10.009. PMID: 14751427
REM latency, dexamethasone suppression test, and thyroid releasing hormone stimulation test in posttraumatic stress disorder.
Reist C, Kauffmann CD, Chicz-Demet A, Chen CC, Demet EM
Prog Neuropsychopharmacol Biol Psychiatry 1995 May;19(3):433-43. doi: 10.1016/0278-5846(95)00024-p. PMID: 7624494
Growth hormone response to thyrotropin releasing hormone in a pellagrin.
Ieiri T, Kuroda H, Shimoda S
Endocrinol Jpn 1984 Aug;31(4):483-90. doi: 10.1507/endocrj1954.31.483. PMID: 6440781
The dexamethasone suppression and thyrotropin-releasing hormone tests and response to treatment in unipolar depression.
Extein I, Kirstein LS, Pottash AL, Gold MS
Int J Psychiatry Med 1982-1983;12(4):267-74. doi: 10.2190/a6le-qva9-1ll1-xv49. PMID: 6820012

Prognosis

Growth hormone response to thyrotropin releasing hormone in a pellagrin.
Ieiri T, Kuroda H, Shimoda S
Endocrinol Jpn 1984 Aug;31(4):483-90. doi: 10.1507/endocrj1954.31.483. PMID: 6440781
Violent suicidal behavior and the thyrotropin-releasing hormone-thyroid-stimulating hormone test: a clinical outcome study.
Linkowski P, Van Wettere JP, Kerkhofs M, Gregoire F, Brauman H, Mendlewicz J
Neuropsychobiology 1984;12(1):19-22. doi: 10.1159/000118104. PMID: 6440049
The dexamethasone suppression and thyrotropin-releasing hormone tests and response to treatment in unipolar depression.
Extein I, Kirstein LS, Pottash AL, Gold MS
Int J Psychiatry Med 1982-1983;12(4):267-74. doi: 10.2190/a6le-qva9-1ll1-xv49. PMID: 6820012
Neuroendocrine measures in psychiatric patients: course and outcome with ECT.
Papakostas Y, Fink M, Lee J, Irwin P, Johnson L
Psychiatry Res 1981 Feb;4(1):55-64. doi: 10.1016/0165-1781(81)90008-1. PMID: 6784139
Clinical value of the thyrotropin-releasing hormone stimulation test in predicting mild hypothyroid state in chronic thyroiditis.
Takeda R, Nakabayashi H, Kawato M, Ueda M, Matsubara F
Endokrinologie 1975 Jul;65(2):171-6. PMID: 819255

Clinical prediction guides

Growth hormone response to thyrotropin releasing hormone in a pellagrin.
Ieiri T, Kuroda H, Shimoda S
Endocrinol Jpn 1984 Aug;31(4):483-90. doi: 10.1507/endocrj1954.31.483. PMID: 6440781
Violent suicidal behavior and the thyrotropin-releasing hormone-thyroid-stimulating hormone test: a clinical outcome study.
Linkowski P, Van Wettere JP, Kerkhofs M, Gregoire F, Brauman H, Mendlewicz J
Neuropsychobiology 1984;12(1):19-22. doi: 10.1159/000118104. PMID: 6440049
Prolactin and thyrotrophin responses to thyroliberin (TRH) in patients with growth hormone deficiency: study in 167 patients.
Garnier PE, Roger M, Chaussain JL, Canlorbe P, Job JC
Acta Endocrinol (Copenh) 1983 Aug;103(4):433-40. doi: 10.1530/acta.0.1030433. PMID: 6412497
Pituitary microadenoma: diagnostic studies.
Pineda G, Valdes M, Castro M, Stevenson C
Clin Endocrinol (Oxf) 1979 Jun;10(6):583-94. doi: 10.1111/j.1365-2265.1979.tb02118.x. PMID: 113146
Clinical value of the thyrotropin-releasing hormone stimulation test in predicting mild hypothyroid state in chronic thyroiditis.
Takeda R, Nakabayashi H, Kawato M, Ueda M, Matsubara F
Endokrinologie 1975 Jul;65(2):171-6. PMID: 819255

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