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Metastatic Vulvar Squamous Cell Carcinoma

MedGen UID:
1761005
•Concept ID:
C5420649
•
Neoplastic Process

Definition

Vulvar squamous cell carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Vulvar Squamous Cell Carcinoma

Professional guidelines

PubMed

Immune checkpoint blockade with anti-programmed cell death 1 (PD-1) monoclonal antibody (mAb) cemiplimab: ongoing and future perspectives in rare genital cancers treatment.
Gambale E, Fancelli S, Caliman E, Petrella MC, Doni L, Pillozzi S, Antonuzzo L
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003540. PMID: 35101944Free PMC Article
Systemic treatment of vulvar cancer.
Mahner S, Prieske K, Grimm D, Trillsch F, Prieske S, von Amsberg G, Petersen C, Mueller V, Jaenicke F, Woelber L
Expert Rev Anticancer Ther 2015 Jun;15(6):629-37. Epub 2015 May 21 doi: 10.1586/14737140.2015.1037837. PMID: 25997120
ACR Appropriateness Criteria® management of locoregionally advanced squamous cell carcinoma of the vulva.
Expert Panel on Radiation Oncology-Gynecology, Kidd E, Moore D, Varia MA, Gaffney DK, Elshaikh MA, Erickson B, Jhingran A, Lee LJ, Mayr NA, Puthawala AA, Rao GG, Small W Jr, Wahl AO, Wolfson AH, Yashar CM, Yuh W, Cardenes HR
Am J Clin Oncol 2013 Aug;36(4):415-22. doi: 10.1097/COC.0b013e318295af1d. PMID: 23872794

Recent clinical studies

Etiology

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Vulvar and Anal Intraepithelial Neoplasia: Terminology, Diagnosis, and Ancillary Studies.
Yang EJ, Kong CS, Longacre TA
Adv Anat Pathol 2017 May;24(3):136-150. doi: 10.1097/PAP.0000000000000149. PMID: 28398952
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Diagnosis

Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Vulvar and Anal Intraepithelial Neoplasia: Terminology, Diagnosis, and Ancillary Studies.
Yang EJ, Kong CS, Longacre TA
Adv Anat Pathol 2017 May;24(3):136-150. doi: 10.1097/PAP.0000000000000149. PMID: 28398952
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Therapy

Immune checkpoints inhibitors in metastatic squamous cell carcinoma of the vulva.
Assi T, Kattan J, Othman A, Farhat F
Future Oncol 2021 Aug;17(24):3133-3135. Epub 2021 Jul 2 doi: 10.2217/fon-2021-0610. PMID: 34213372
Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Prognosis

Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.
How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A
Sci Rep 2021 Feb 11;11(1):3667. doi: 10.1038/s41598-021-83317-7. PMID: 33574401Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Clinical prediction guides

TROP-2 is widely expressed in vulvar squamous cell carcinoma and represents a potential new therapeutic target.
Condic M, Egger EK, Klümper N, Kristiansen G, Mustea A, Thiesler T, Ralser DJ
J Cancer Res Clin Oncol 2023 Sep;149(11):8235-8241. Epub 2023 Apr 17 doi: 10.1007/s00432-023-04761-8. PMID: 37067548Free PMC Article
Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial.
How JA, Jazaeri AA, Soliman PT, Fleming ND, Gong J, Piha-Paul SA, Janku F, Stephen B, Naing A
Sci Rep 2021 Feb 11;11(1):3667. doi: 10.1038/s41598-021-83317-7. PMID: 33574401Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Recent systematic reviews

Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review.
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Cutaneous metastasis from vulvar squamous cell carcinoma: a rare occurrence that should not be forgotten.
Bizzarri N, Vellone VG, Parodi L, Calanni Fraccono L, Ghirardi V, Costantini S, Menada MV, Sala P
J Obstet Gynaecol 2017 Nov;37(8):975-981. Epub 2017 Jun 28 doi: 10.1080/01443615.2017.1318269. PMID: 28657384
Vulvar, Perianal and Perineal Cancer After Hidradenitis Suppurativa: A Systematic Review and Pooled Analysis.
Makris GM, Poulakaki N, Papanota AM, Kotsifa E, Sergentanis TN, Psaltopoulou T
Dermatol Surg 2017 Jan;43(1):107-115. doi: 10.1097/DSS.0000000000000944. PMID: 27755170
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023

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