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Gallbladder Intracholecystic Papillary Neoplasm with an Associated Invasive Carcinoma

MedGen UID:
1763551
•Concept ID:
C5399921
•
Neoplastic Process
Synonyms: Gallbladder ICPN with an Associated Invasive Carcinoma; Gallbladder Intracholecystic Papillary (Tubular) Neoplasm with an Associated Invasive Carcinoma; Gallbladder Intracystic/Intaductal Papillary Neoplasm with an Associated Invasive Carcinoma; Intracystic Papillary Neoplasm with an Associated Invasive Carcinoma

Definition

An intracholecystic papillary neoplasm, usually with high grade intraepithelial neoplasia, that arises from the gallbladder. It is associated with the presence of an invasive carcinoma. The carcinomatous component is an adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Intracholecystic Papillary Neoplasm with an Associated Invasive Carcinoma

Professional guidelines

PubMed

Intraductal tubulopapillary neoplasms of the bile ducts: identity, clinicopathologic characteristics, and differential diagnosis of a distinct entity among intraductal tumors.
Pehlivanoglu B, Adsay V
Hum Pathol 2023 Feb;132:12-19. Epub 2022 Aug 5 doi: 10.1016/j.humpath.2022.07.019. PMID: 35934108

Recent clinical studies

Etiology

Contrast-Enhanced CT and Ultrasonography Features of Intracholecystic Papillary Neoplasm with or without associated Invasive Carcinoma.
Kim JH, Kim JH, Kang HJ, Bae JS
Korean J Radiol 2023 Jan;24(1):39-50. doi: 10.3348/kjr.2022.0577. PMID: 36606619Free PMC Article
Intracholecystic tubular non-mucinous neoplasm (ICTN) of the gallbladder: a clinicopathologically distinct, invasion-resistant entity.
Pehlivanoglu B, Balci S, Basturk O, Bagci P, Erbarut Seven I, Memis B, Dursun N, Jang KT, Saka B, Ohike N, Tajiri T, Roa JC, Sarmiento JM, Reid MD, Adsay V
Virchows Arch 2021 Mar;478(3):435-447. Epub 2020 Jul 20 doi: 10.1007/s00428-020-02877-7. PMID: 32691142
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder: A Short Review of Literature.
Saei Hamedani F, Garcia-Buitrago M
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):57-61. doi: 10.1097/PAI.0000000000000711. PMID: 31815746
Intracholecystic papillary-tubular neoplasm of gallbladder: A 5-year retrospective pathological study.
Hazarika P, Sharma MK
Indian J Pathol Microbiol 2018 Oct-Dec;61(4):516-519. doi: 10.4103/IJPM.IJPM_489_17. PMID: 30303140
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D
Int J Surg Pathol 2016 Sep;24(6):504-11. Epub 2016 Apr 27 doi: 10.1177/1066896916644781. PMID: 27122163

Diagnosis

Intracholecystic papillary neoplasm: potential differential diagnosis before a gallbladder polyp.
Aparicio-López D, Cerdán Pascual R, Rodríguez Artigas JM, Cantín Blázquez S, Royo Dachary P, Serradilla Martin M, Ligorred Padilla LA, Dobón Rascón MÁ
Rev Esp Enferm Dig 2023 Sep;115(9):525-526. doi: 10.17235/reed.2022.9344/2022. PMID: 36454096
The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder.
Sarıtaş AG, Topal U, Ülkü A, Akçam AT, Erdoğan K, Aydın İ
Ann Ital Chir 2020 Feb 9;9 PMID: 32039884
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder: A Short Review of Literature.
Saei Hamedani F, Garcia-Buitrago M
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):57-61. doi: 10.1097/PAI.0000000000000711. PMID: 31815746
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Prognosis

Contrast-Enhanced CT and Ultrasonography Features of Intracholecystic Papillary Neoplasm with or without associated Invasive Carcinoma.
Kim JH, Kim JH, Kang HJ, Bae JS
Korean J Radiol 2023 Jan;24(1):39-50. doi: 10.3348/kjr.2022.0577. PMID: 36606619Free PMC Article
Intracholecystic papillary neoplasm: potential differential diagnosis before a gallbladder polyp.
Aparicio-López D, Cerdán Pascual R, Rodríguez Artigas JM, Cantín Blázquez S, Royo Dachary P, Serradilla Martin M, Ligorred Padilla LA, Dobón Rascón MÁ
Rev Esp Enferm Dig 2023 Sep;115(9):525-526. doi: 10.17235/reed.2022.9344/2022. PMID: 36454096
The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D
Int J Surg Pathol 2016 Sep;24(6):504-11. Epub 2016 Apr 27 doi: 10.1177/1066896916644781. PMID: 27122163
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

Clinical prediction guides

Lymph node metastatic status could predict the prognosis of intracholecystic papillary neoplasm of gallbladder.
Nakayama M, Naito Y, Sadashima E, Kinjo Y, Kawahara A, Hisaka T, Okabe Y, Akiba J, Yano H
Hum Pathol 2023 Jul;137:63-70. Epub 2023 Apr 29 doi: 10.1016/j.humpath.2023.04.013. PMID: 37127081
Contrast-Enhanced CT and Ultrasonography Features of Intracholecystic Papillary Neoplasm with or without associated Invasive Carcinoma.
Kim JH, Kim JH, Kang HJ, Bae JS
Korean J Radiol 2023 Jan;24(1):39-50. doi: 10.3348/kjr.2022.0577. PMID: 36606619Free PMC Article
Intracholecystic tubular non-mucinous neoplasm (ICTN) of the gallbladder: a clinicopathologically distinct, invasion-resistant entity.
Pehlivanoglu B, Balci S, Basturk O, Bagci P, Erbarut Seven I, Memis B, Dursun N, Jang KT, Saka B, Ohike N, Tajiri T, Roa JC, Sarmiento JM, Reid MD, Adsay V
Virchows Arch 2021 Mar;478(3):435-447. Epub 2020 Jul 20 doi: 10.1007/s00428-020-02877-7. PMID: 32691142
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D
Int J Surg Pathol 2016 Sep;24(6):504-11. Epub 2016 Apr 27 doi: 10.1177/1066896916644781. PMID: 27122163

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