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Metastatic Ovarian Clear Cell Adenocarcinoma

MedGen UID:
1763741
•Concept ID:
C5418892
•
Neoplastic Process

Definition

Ovarian clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Ovarian Clear Cell Adenocarcinoma

Professional guidelines

PubMed

Past, Present, and Future of Serum Tumor Markers in Management of Ovarian Cancer: A Guide for the Radiologist.
Rao S, Smith DA, Guler E, Kikano EG, Rajdev MA, Yoest JM, Ramaiya NH, Tirumani SH
Radiographics 2021 Oct;41(6):1839-1856. doi: 10.1148/rg.2021210005. PMID: 34597221
Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model.
Ishikura N, Yorozu K, Kurasawa M, Yanagisawa M, Sugimoto M, Yamamoto K
Oncol Rep 2019 Sep;42(3):1057-1065. Epub 2019 Jun 26 doi: 10.3892/or.2019.7211. PMID: 31322247Free PMC Article
Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects.
Altaras MM, Aviram R, Cohen I, Cordoba M, Weiss E, Beyth Y
Gynecol Oncol 1991 Mar;40(3):230-6. doi: 10.1016/0090-8258(90)90283-q. PMID: 2013445

Recent clinical studies

Etiology

Pan-cancer whole-genome comparison of primary and metastatic solid tumours.
Martínez-Jiménez F, Movasati A, Brunner SR, Nguyen L, Priestley P, Cuppen E, Van Hoeck A
Nature 2023 Jun;618(7964):333-341. Epub 2023 May 10 doi: 10.1038/s41586-023-06054-z. PMID: 37165194Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379
Endometriosis-associated ovarian cancer: a clinicopathologic review.
Steed H, Chapman W, Laframboise S
J Obstet Gynaecol Can 2004 Aug;26(8):709-15. doi: 10.1016/s1701-2163(16)30642-9. PMID: 15307975

Diagnosis

Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Cytomorphology of ovarian clear cell carcinomas in peritoneal effusions.
Damiani D, Suciu V, Genestie C, Vielh P
Cytopathology 2016 Dec;27(6):427-432. Epub 2016 Mar 2 doi: 10.1111/cyt.12297. PMID: 26932246
Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
CT of epithelial ovarian tumors.
Kawamoto S, Urban BA, Fishman EK
Radiographics 1999 Oct;19 Spec No:S85-102; quiz S263-4. doi: 10.1148/radiographics.19.suppl_1.g99oc10s85. PMID: 10517447

Therapy

Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma.
Mehner C, Miller E, Hockla A, Coban M, Weroha SJ, Radisky DC, Radisky ES
Oncogene 2020 Oct;39(42):6606-6618. Epub 2020 Sep 14 doi: 10.1038/s41388-020-01451-4. PMID: 32929152Free PMC Article
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
Endometriosis-associated ovarian cancer: a clinicopathologic review.
Steed H, Chapman W, Laframboise S
J Obstet Gynaecol Can 2004 Aug;26(8):709-15. doi: 10.1016/s1701-2163(16)30642-9. PMID: 15307975
Perspectives on research in gynecologic oncology.
DeVita VT Jr, Wasserman TH, Young RC, Carter SK
Cancer 1976 Jul;38(1 SUPPL):509-25. doi: 10.1002/1097-0142(197607)38:1<509::aid-cncr2820380175>3.0.co;2-a. PMID: 776390

Prognosis

A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations.
Stružinská I, Hájková N, Hojný J, Krkavcová E, Michálková R, Dvořák J, Němejcová K, Matěj R, Laco J, Drozenová J, Fabian P, Hausnerová J, Méhes G, Škapa P, Švajdler M, Cibula D, Frühauf F, Bártů MK, Dundr P
Diagn Pathol 2023 Jun 12;18(1):72. doi: 10.1186/s13000-023-01358-0. PMID: 37303048Free PMC Article
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Primary ovarian clear cell carcinoma of the abdominal wall--a systematic review of the literature to establish optimal surgical management.
Ohler A, Dudziak M, Sznurkowski JJ
Ginekol Pol 2015 Aug;86(8):574-81. PMID: 26492705
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article

Clinical prediction guides

A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations.
Stružinská I, Hájková N, Hojný J, Krkavcová E, Michálková R, Dvořák J, Němejcová K, Matěj R, Laco J, Drozenová J, Fabian P, Hausnerová J, Méhes G, Škapa P, Švajdler M, Cibula D, Frühauf F, Bártů MK, Dundr P
Diagn Pathol 2023 Jun 12;18(1):72. doi: 10.1186/s13000-023-01358-0. PMID: 37303048Free PMC Article
Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma.
Mehner C, Miller E, Hockla A, Coban M, Weroha SJ, Radisky DC, Radisky ES
Oncogene 2020 Oct;39(42):6606-6618. Epub 2020 Sep 14 doi: 10.1038/s41388-020-01451-4. PMID: 32929152Free PMC Article
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Primary ovarian clear cell carcinoma of the abdominal wall--a systematic review of the literature to establish optimal surgical management.
Ohler A, Dudziak M, Sznurkowski JJ
Ginekol Pol 2015 Aug;86(8):574-81. PMID: 26492705

Recent systematic reviews

Histologic Subtypes in Endometriosis-Associated Ovarian Cancer and Ovarian Cancer Arising in Endometriosis: A Systematic Review and Meta-Analysis.
Chiaffarino F, Cipriani S, Ricci E, Esposito G, Parazzini F, Vercellini P
Reprod Sci 2024 Jun;31(6):1642-1650. Epub 2024 Mar 4 doi: 10.1007/s43032-024-01489-9. PMID: 38438776Free PMC Article
Clear cell carcinoma of the stomach: a rare tumor variant imparting poor prognosis.
Virgilio E, Rampioni GL, Lombardi M, Balducci G, Pilozzi E, Cavallini M
Acta Chir Belg 2023 Feb;123(1):65-67. Epub 2021 Mar 18 doi: 10.1080/00015458.2021.1900520. PMID: 33710937
Primary ovarian clear cell carcinoma of the abdominal wall--a systematic review of the literature to establish optimal surgical management.
Ohler A, Dudziak M, Sznurkowski JJ
Ginekol Pol 2015 Aug;86(8):574-81. PMID: 26492705

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