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Pleomorphic Fibroma

MedGen UID:
1764047
•Concept ID:
C5399786
•
Neoplastic Process
Synonym: Pleomorphic fibroma
SNOMED CT: Pleomorphic fibroma (448015002); Pleomorphic fibroma (1187237009)

Definition

A benign, often polypoid, fibroblastic neoplasm characterized by bizarre pleomorphic cells. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic Fibroma

Professional guidelines

PubMed

Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.
Rakha EA, Badve S, Eusebi V, Reis-Filho JS, Fox SB, Dabbs DJ, Decker T, Hodi Z, Ichihara S, Lee AH, Palacios J, Richardson AL, Vincent-Salomon A, Schmitt FC, Tan PH, Tse GM, Ellis IO
Histopathology 2016 Jan;68(1):45-56. doi: 10.1111/his.12861. PMID: 26348644Free PMC Article
Myxofibrosarcoma: cytomorphologic findings and differential diagnosis on fine needle aspiration.
Olson MT, Ali SZ
Acta Cytol 2012;56(1):15-24. Epub 2012 Jan 4 doi: 10.1159/000333134. PMID: 22236741
Endoscopic management of benign sinonasal tumors: a decade of experience.
London SD, Schlosser RJ, Gross CW
Am J Rhinol 2002 Jul-Aug;16(4):221-7. PMID: 12222948

Recent clinical studies

Etiology

Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Cutaneous pleomorphic fibromas arising in patients with germline TP53 mutations.
Cloutier JM, Shalin SC, Lindberg M, Gardner JM, Fernandez-Pol S, Zaba L, Novoa R, Brown RA
J Cutan Pathol 2020 Aug;47(8):734-741. Epub 2020 Apr 6 doi: 10.1111/cup.13686. PMID: 32187703
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Dome-shaped papule on the posterior shoulder--quiz case. Myxoid cutaneous pleomorphic fibroma.
McCoppin HH, Wieberg J, Dyer JA, Feldman M
Arch Dermatol 2010 Sep;146(9):1037-42. doi: 10.1001/archdermatol.2010.215-a. PMID: 20855711
Progression of a myxoid pleomorphic fibroma to myxofibrosarcoma.
Dore A, Robertson I, Williamson R, Weedon D
Australas J Dermatol 2003 Nov;44(4):287-90. doi: 10.1046/j.1440-0960.2003.00012.x. PMID: 14616499

Diagnosis

Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Subungual pleomorphic fibroma: a case report and review of the literature.
Halteh P, Magro CM, Lipner SR
Dermatol Online J 2016 Nov 15;22(11) PMID: 28329563
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature.
Al-Zaid T, Frieling G, Rosenthal S
J Cutan Pathol 2013 Aug;40(8):734-9. Epub 2013 May 8 doi: 10.1111/cup.12164. PMID: 23651098
Subungual pleomorphic fibroma.
Hsieh YJ, Lin YC, Wu YH, Su HY, Billings SD, Hood AF
J Cutan Pathol 2003 Oct;30(9):569-71. doi: 10.1034/j.1600-0560.2003.00105.x. PMID: 14507406

Therapy

Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis.
Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP
J Cutan Pathol 2017 Aug;44(8):665-671. Epub 2017 Jun 13 doi: 10.1111/cup.12965. PMID: 28543636

Prognosis

Pleomorphic Fibroma: A Clinicopathologic Case Series With the Review of the Literature.
Potts GA, Adlam T, Stierman SC, Moossavi M, Mehregan D
Am J Dermatopathol 2021 Aug 1;43(8):560-566. doi: 10.1097/DAD.0000000000001879. PMID: 33534206
Cutaneous pleomorphic fibromas arising in patients with germline TP53 mutations.
Cloutier JM, Shalin SC, Lindberg M, Gardner JM, Fernandez-Pol S, Zaba L, Novoa R, Brown RA
J Cutan Pathol 2020 Aug;47(8):734-741. Epub 2020 Apr 6 doi: 10.1111/cup.13686. PMID: 32187703
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Pleomorphic fibroma of skin. A case report and immunohistochemical study.
Layfield LJ, Fain JS
Arch Pathol Lab Med 1991 Oct;115(10):1046-9. PMID: 1898234
Pleomorphic fibroma of the skin: a benign neoplasm with cytologic atypia. A clinicopathologic study of eight cases.
Kamino H, Lee JY, Berke A
Am J Surg Pathol 1989 Feb;13(2):107-13. PMID: 2916726

Clinical prediction guides

Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Differential expression of CD34 and Ki-M1p in pleomorphic fibroma and dermatofibroma with monster cells.
Rudolph P, Schubert C, Zelger BG, Zelger B, Parwaresch R
Am J Dermatopathol 1999 Oct;21(5):414-9. doi: 10.1097/00000372-199910000-00002. PMID: 10535568

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