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Advanced Malignant Mixed Mesodermal (Mullerian) Tumor

MedGen UID:
1768582
•Concept ID:
C5418884
•
Neoplastic Process

Definition

A malignant mixed mesodermal (Mullerian) tumor that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Malignant Mixed Mesodermal (Mullerian) Tumor

Recent clinical studies

Etiology

Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Clinical features of advanced ovarian mixed mesodermal tumors and treatment with doxorubicin- and cis-platinum-based chemotherapy.
Plaxe SC, Dottino PR, Goodman HM, Deligdisch L, Idelson M, Cohen CJ
Gynecol Oncol 1990 May;37(2):244-9. doi: 10.1016/0090-8258(90)90341-h. PMID: 2160905
Cisplatin and adriamycin combination chemotherapy for uterine stromal sarcomas and mixed mesodermal tumors.
Peters WA 3rd, Rivkin SE, Smith MR, Tesh DE
Gynecol Oncol 1989 Sep;34(3):323-7. doi: 10.1016/0090-8258(89)90166-2. PMID: 2767523

Diagnosis

Primary ovarian malignant mixed mesodermal tumor: report of four cases.
Ki EY, Park JS, Mun JB, Hur SY
Eur J Gynaecol Oncol 2014;35(5):584-8. PMID: 25423710
Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis.
Kurman RJ, Visvanathan K, Roden R, Wu TC, Shih IeM
Am J Obstet Gynecol 2008 Apr;198(4):351-6. doi: 10.1016/j.ajog.2008.01.005. PMID: 18395030Free PMC Article
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Malignant mixed mesodermal tumors of the ovary: a clinicopathologic assessment of 12 cases.
Barwick KW, LiVolsi VA
Am J Surg Pathol 1980 Feb;4(1):37-42. PMID: 6244746

Therapy

Unexpected uterine sarcomas in 4478 patients with electric power morcellation for leiomyomas.
Chen Q, Shi H, Lu W, Lu B
Eur J Obstet Gynecol Reprod Biol 2018 Nov;230:85-89. Epub 2018 Sep 13 doi: 10.1016/j.ejogrb.2018.09.027. PMID: 30245442
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Systemic therapy for advanced uterine sarcoma: a systematic review of the literature.
Kanjeekal S, Chambers A, Fung MF, Verma S
Gynecol Oncol 2005 May;97(2):624-37. doi: 10.1016/j.ygyno.2005.01.041. PMID: 15863170
Clinical features of advanced ovarian mixed mesodermal tumors and treatment with doxorubicin- and cis-platinum-based chemotherapy.
Plaxe SC, Dottino PR, Goodman HM, Deligdisch L, Idelson M, Cohen CJ
Gynecol Oncol 1990 May;37(2):244-9. doi: 10.1016/0090-8258(90)90341-h. PMID: 2160905
Cisplatin and adriamycin combination chemotherapy for uterine stromal sarcomas and mixed mesodermal tumors.
Peters WA 3rd, Rivkin SE, Smith MR, Tesh DE
Gynecol Oncol 1989 Sep;34(3):323-7. doi: 10.1016/0090-8258(89)90166-2. PMID: 2767523

Prognosis

Unexpected uterine sarcomas in 4478 patients with electric power morcellation for leiomyomas.
Chen Q, Shi H, Lu W, Lu B
Eur J Obstet Gynecol Reprod Biol 2018 Nov;230:85-89. Epub 2018 Sep 13 doi: 10.1016/j.ejogrb.2018.09.027. PMID: 30245442
Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases.
Barakat RR, Rubin SC, Wong G, Saigo PE, Markman M, Hoskins WJ
Obstet Gynecol 1992 Oct;80(4):660-4. PMID: 1328975
Clinical features of advanced ovarian mixed mesodermal tumors and treatment with doxorubicin- and cis-platinum-based chemotherapy.
Plaxe SC, Dottino PR, Goodman HM, Deligdisch L, Idelson M, Cohen CJ
Gynecol Oncol 1990 May;37(2):244-9. doi: 10.1016/0090-8258(90)90341-h. PMID: 2160905
Cisplatin and adriamycin combination chemotherapy for uterine stromal sarcomas and mixed mesodermal tumors.
Peters WA 3rd, Rivkin SE, Smith MR, Tesh DE
Gynecol Oncol 1989 Sep;34(3):323-7. doi: 10.1016/0090-8258(89)90166-2. PMID: 2767523

Clinical prediction guides

Tissue and serum CA125 expression in endometrial cancer.
Ginath S, Menczer J, Fintsi Y, Ben-Shem E, Glezerman M, Avinoach I
Int J Gynecol Cancer 2002 Jul-Aug;12(4):372-5. doi: 10.1046/j.1525-1438.2002.01007.x. PMID: 12144685
Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature.
Perret L, Chaubert P, Hessler D, Guillou L
Cancer 1998 Apr 15;82(8):1535-49. PMID: 9554532
A phase II trial of ifosfamide and mesna in patients with advanced or recurrent mixed mesodermal tumors of the ovary previously treated with platinum-based chemotherapy: a Gynecologic Oncology Group study.
Sutton GP, Blessing JA, Homesley HD, Malfetano JH
Gynecol Oncol 1994 Apr;53(1):24-6. doi: 10.1006/gyno.1994.1081. PMID: 8175017
Mixed mesodermal tumor of the ovary: analysis of prognostic factors in 31 cases.
Barakat RR, Rubin SC, Wong G, Saigo PE, Markman M, Hoskins WJ
Obstet Gynecol 1992 Oct;80(4):660-4. PMID: 1328975

Recent systematic reviews

Systemic therapy for advanced uterine sarcoma: a systematic review of the literature.
Kanjeekal S, Chambers A, Fung MF, Verma S
Gynecol Oncol 2005 May;97(2):624-37. doi: 10.1016/j.ygyno.2005.01.041. PMID: 15863170

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