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Unresectable Lung Non-Small Cell Squamous Carcinoma

MedGen UID:
1769067
•Concept ID:
C5419211
•
Neoplastic Process

Definition

Lung non-small cell squamous carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Lung Non-Small Cell Squamous Carcinoma

Professional guidelines

PubMed

Role of CTLA Inhibition in Management of Non-Small Cell Lung Cancer.
Kerrigan K, Puri S
Curr Oncol Rep 2022 Jan;24(1):113-123. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01164-1. PMID: 35060001
Immunotherapy Alone or in Combination with Chemotherapy as First-Line Treatment of Non-Small Cell Lung Cancer.
Saxena P, Singh PK, Malik PS, Singh N
Curr Treat Options Oncol 2020 Jul 27;21(8):69. doi: 10.1007/s11864-020-00768-2. PMID: 32720019
Pemetrexed in first-line treatment of non-small cell lung cancer.
Esteban E, Casillas M, Cassinello A
Cancer Treat Rev 2009 Jun;35(4):364-73. Epub 2009 Mar 6 doi: 10.1016/j.ctrv.2009.02.002. PMID: 19269106

Recent clinical studies

Etiology

Trastuzumab deruxtecan in patients with metastatic non-small-cell lung cancer (DESTINY-Lung01): primary results of the HER2-overexpressing cohorts from a single-arm, phase 2 trial.
Smit EF, Felip E, Uprety D, Nagasaka M, Nakagawa K, Paz-Ares Rodríguez L, Pacheco JM, Li BT, Planchard D, Baik C, Goto Y, Murakami H, Saltos A, Pereira K, Taguchi A, Cheng Y, Yan Q, Feng W, Tsuchihashi Z, Jänne PA
Lancet Oncol 2024 Apr;25(4):439-454. doi: 10.1016/S1470-2045(24)00064-0. PMID: 38547891
Biomarker Testing in Patients With Unresectable Advanced or Recurrent Non-Small Cell Lung Cancer.
Sakamoto T, Matsubara T, Takahama T, Yokoyama T, Nakamura A, Tokito T, Okamoto T, Akamatsu H, Oki M, Sato Y, Tobino K, Ikeda S, Mori M, Mimura C, Maeno K, Miura S, Harada T, Nishimura K, Hiraoka M, Kenmotsu H, Fujimoto J, Shimokawa M, Yamamoto N, Nakagawa K
JAMA Netw Open 2023 Dec 1;6(12):e2347700. doi: 10.1001/jamanetworkopen.2023.47700. PMID: 38100106Free PMC Article
Rationale and Design of the Phase III KEYLYNK-012 Study of Pembrolizumab and Concurrent Chemoradiotherapy Followed by Pembrolizumab With or Without Olaparib for Stage III Non-Small-Cell Lung Cancer.
Jabbour SK, Cho BC, Bria E, Kato T, Bhosle J, Gainor JF, Reguart N, Wang L, Morgensztern D, Shentu Y, Kim SJ, Souza F, Reck M
Clin Lung Cancer 2022 Sep;23(6):e342-e346. Epub 2022 Apr 29 doi: 10.1016/j.cllc.2022.04.003. PMID: 35618629Free PMC Article
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study.
Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H
Lancet Oncol 2015 Feb;16(2):187-99. Epub 2015 Jan 16 doi: 10.1016/S1470-2045(14)71207-0. PMID: 25601342Free PMC Article

Diagnosis

Biomarker Testing in Patients With Unresectable Advanced or Recurrent Non-Small Cell Lung Cancer.
Sakamoto T, Matsubara T, Takahama T, Yokoyama T, Nakamura A, Tokito T, Okamoto T, Akamatsu H, Oki M, Sato Y, Tobino K, Ikeda S, Mori M, Mimura C, Maeno K, Miura S, Harada T, Nishimura K, Hiraoka M, Kenmotsu H, Fujimoto J, Shimokawa M, Yamamoto N, Nakagawa K
JAMA Netw Open 2023 Dec 1;6(12):e2347700. doi: 10.1001/jamanetworkopen.2023.47700. PMID: 38100106Free PMC Article
Lung adenocarcinoma and squamous cell carcinoma difficult for immunohistochemical diagnosis can be distinguished by lipid profile.
Yamashita T, Takanashi Y, Uebayashi A, Oka M, Mizuno K, Kawase A, Oyama S, Kitamoto T, Kondo M, Omori S, Tao H, Takahashi Y, Sakamoto T, Kahyo T, Sugimura H, Setou M, Shiiya N, Funai K
Sci Rep 2023 Jul 26;13(1):12092. doi: 10.1038/s41598-023-37848-w. PMID: 37495609Free PMC Article
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Deciphering unclassified tumors of non-small-cell lung cancer through radiomics.
Saad M, Choi TS
Comput Biol Med 2017 Dec 1;91:222-230. doi: 10.1016/j.compbiomed.2017.10.029. PMID: 29100116
Current state-of-the-art therapy for advanced squamous cell lung cancer.
Scagliotti GV, Novello S, Rapetti S, Papotti M
Am Soc Clin Oncol Educ Book 2013:354-8. doi: 10.14694/EdBook_AM.2013.33.354. PMID: 23714545

Therapy

Trastuzumab deruxtecan in patients with metastatic non-small-cell lung cancer (DESTINY-Lung01): primary results of the HER2-overexpressing cohorts from a single-arm, phase 2 trial.
Smit EF, Felip E, Uprety D, Nagasaka M, Nakagawa K, Paz-Ares Rodríguez L, Pacheco JM, Li BT, Planchard D, Baik C, Goto Y, Murakami H, Saltos A, Pereira K, Taguchi A, Cheng Y, Yan Q, Feng W, Tsuchihashi Z, Jänne PA
Lancet Oncol 2024 Apr;25(4):439-454. doi: 10.1016/S1470-2045(24)00064-0. PMID: 38547891
Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges.
Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM
Lung Cancer 2021 Dec;162:42-53. Epub 2021 Sep 15 doi: 10.1016/j.lungcan.2021.09.003. PMID: 34739853
Chemotherapy for advanced non-small cell lung cancer with a focus on squamous cell carcinoma.
Kuribayashi K, Funaguchi N, Nakano T
J Cancer Res Ther 2016 Apr-Jun;12(2):528-34. doi: 10.4103/0973-1482.174185. PMID: 27461605
Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study.
Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H
Lancet Oncol 2015 Feb;16(2):187-99. Epub 2015 Jan 16 doi: 10.1016/S1470-2045(14)71207-0. PMID: 25601342Free PMC Article
Vemurafenib.
Garbe C, Abusaif S, Eigentler TK
Recent Results Cancer Res 2014;201:215-25. doi: 10.1007/978-3-642-54490-3_13. PMID: 24756795

Prognosis

Deregulation of AKT-mTOR Signaling Contributes to Chemoradiation Resistance in Lung Squamous Cell Carcinoma.
Shen C, Shyu DL, Xu M, Yang L, Webb A, Duan W, Williams TM
Mol Cancer Res 2022 Mar 1;20(3):425-433. doi: 10.1158/1541-7786.MCR-21-0272. PMID: 34810212Free PMC Article
Computer-assisted subtyping and prognosis for non-small cell lung cancer patients with unresectable tumor.
Saad M, Choi TS
Comput Med Imaging Graph 2018 Jul;67:1-8. Epub 2018 Apr 4 doi: 10.1016/j.compmedimag.2018.04.003. PMID: 29660595
Chemotherapy for advanced non-small cell lung cancer with a focus on squamous cell carcinoma.
Kuribayashi K, Funaguchi N, Nakano T
J Cancer Res Ther 2016 Apr-Jun;12(2):528-34. doi: 10.4103/0973-1482.174185. PMID: 27461605
Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study.
Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H
Lancet Oncol 2015 Feb;16(2):187-99. Epub 2015 Jan 16 doi: 10.1016/S1470-2045(14)71207-0. PMID: 25601342Free PMC Article
Pemetrexed in first-line treatment of non-small cell lung cancer.
Esteban E, Casillas M, Cassinello A
Cancer Treat Rev 2009 Jun;35(4):364-73. Epub 2009 Mar 6 doi: 10.1016/j.ctrv.2009.02.002. PMID: 19269106

Clinical prediction guides

Trastuzumab deruxtecan in patients with metastatic non-small-cell lung cancer (DESTINY-Lung01): primary results of the HER2-overexpressing cohorts from a single-arm, phase 2 trial.
Smit EF, Felip E, Uprety D, Nagasaka M, Nakagawa K, Paz-Ares Rodríguez L, Pacheco JM, Li BT, Planchard D, Baik C, Goto Y, Murakami H, Saltos A, Pereira K, Taguchi A, Cheng Y, Yan Q, Feng W, Tsuchihashi Z, Jänne PA
Lancet Oncol 2024 Apr;25(4):439-454. doi: 10.1016/S1470-2045(24)00064-0. PMID: 38547891
Efficacy and surgical safety of sequential surgical resection after pembrolizumab plus chemotherapy for initial unresectable stage IIIB non-small cell lung cancer.
Zheng J, Li Y, Jin C, Ruan K, Sun K, Chen H, Wang M, Zhang S, Zhou J, Zhou J
Lung Cancer 2023 Oct;184:107326. Epub 2023 Aug 11 doi: 10.1016/j.lungcan.2023.107326. PMID: 37579576
Deregulation of AKT-mTOR Signaling Contributes to Chemoradiation Resistance in Lung Squamous Cell Carcinoma.
Shen C, Shyu DL, Xu M, Yang L, Webb A, Duan W, Williams TM
Mol Cancer Res 2022 Mar 1;20(3):425-433. doi: 10.1158/1541-7786.MCR-21-0272. PMID: 34810212Free PMC Article
Computer-assisted subtyping and prognosis for non-small cell lung cancer patients with unresectable tumor.
Saad M, Choi TS
Comput Med Imaging Graph 2018 Jul;67:1-8. Epub 2018 Apr 4 doi: 10.1016/j.compmedimag.2018.04.003. PMID: 29660595
Deciphering unclassified tumors of non-small-cell lung cancer through radiomics.
Saad M, Choi TS
Comput Biol Med 2017 Dec 1;91:222-230. doi: 10.1016/j.compbiomed.2017.10.029. PMID: 29100116

Recent systematic reviews

Comparison of Concurrent Use of Thoracic Radiation With Either Carboplatin-Paclitaxel or Cisplatin-Etoposide for Patients With Stage III Non-Small-Cell Lung Cancer: A Systematic Review.
Steuer CE, Behera M, Ernani V, Higgins KA, Saba NF, Shin DM, Pakkala S, Pillai RN, Owonikoko TK, Curran WJ, Belani CP, Khuri FR, Ramalingam SS
JAMA Oncol 2017 Aug 1;3(8):1120-1129. doi: 10.1001/jamaoncol.2016.4280. PMID: 27978552
A systematic overview of radiation therapy effects in non-small cell lung cancer.
Sirzén F, Kjellén E, Sörenson S, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):493-515. doi: 10.1080/02841860310014453. PMID: 14596509

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