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Refractory Acute Myeloid Leukemia Not Otherwise Specified

MedGen UID:
1773485
•Concept ID:
C5421350
•
Neoplastic Process

Definition

Acute myeloid leukemia not otherwise specified that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Acute Myeloid Leukemia Not Otherwise Specified

Professional guidelines

PubMed

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
A review of treatment options employed in relapsed/refractory AML.
Mohamed Jiffry MZ, Kloss R, Ahmed-Khan M, Carmona-Pires F, Okam N, Weeraddana P, Dharmaratna D, Dandwani M, Moin K
Hematology 2023 Dec;28(1):2196482. doi: 10.1080/16078454.2023.2196482. PMID: 37036019
Management of Acute Myeloid Leukemia: A Review for General Practitioners in Oncology.
Stubbins RJ, Francis A, Kuchenbauer F, Sanford D
Curr Oncol 2022 Aug 30;29(9):6245-6259. doi: 10.3390/curroncol29090491. PMID: 36135060Free PMC Article
Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association.
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
Emerging Immunotherapy for Acute Myeloid Leukemia.
Tabata R, Chi S, Yuda J, Minami Y
Int J Mol Sci 2021 Feb 16;22(4) doi: 10.3390/ijms22041944. PMID: 33669431Free PMC Article

Diagnosis

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Relapse after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia: an overview of prevention and treatment.
Kreidieh F, Abou Dalle I, Moukalled N, El-Cheikh J, Brissot E, Mohty M, Bazarbachi A
Int J Hematol 2022 Sep;116(3):330-340. Epub 2022 Jul 16 doi: 10.1007/s12185-022-03416-7. PMID: 35841458
Menin Inhibitors in Acute Myeloid Leukemia-What Does the Future Hold?
Swaminathan M, Bourgeois W, Armstrong SA, Wang ES
Cancer J 2022 Jan-Feb 01;28(1):62-66. doi: 10.1097/PPO.0000000000000571. PMID: 35072375
A review of FLT3 inhibitors in acute myeloid leukemia.
Zhao JC, Agarwal S, Ahmad H, Amin K, Bewersdorf JP, Zeidan AM
Blood Rev 2022 Mar;52:100905. Epub 2021 Nov 3 doi: 10.1016/j.blre.2021.100905. PMID: 34774343Free PMC Article
Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges.
Shallis RM, Wang R, Davidoff A, Ma X, Zeidan AM
Blood Rev 2019 Jul;36:70-87. Epub 2019 Apr 29 doi: 10.1016/j.blre.2019.04.005. PMID: 31101526

Therapy

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Leukemic stem cells and therapy resistance in acute myeloid leukemia.
Stelmach P, Trumpp A
Haematologica 2023 Feb 1;108(2):353-366. doi: 10.3324/haematol.2022.280800. PMID: 36722405Free PMC Article
A review of FLT3 inhibitors in acute myeloid leukemia.
Zhao JC, Agarwal S, Ahmad H, Amin K, Bewersdorf JP, Zeidan AM
Blood Rev 2022 Mar;52:100905. Epub 2021 Nov 3 doi: 10.1016/j.blre.2021.100905. PMID: 34774343Free PMC Article
Emerging Immunotherapy for Acute Myeloid Leukemia.
Tabata R, Chi S, Yuda J, Minami Y
Int J Mol Sci 2021 Feb 16;22(4) doi: 10.3390/ijms22041944. PMID: 33669431Free PMC Article
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article

Prognosis

Venetoclax Combined With FLAG-IDA Induction and Consolidation in Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia.
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Emerging Immunotherapy for Acute Myeloid Leukemia.
Tabata R, Chi S, Yuda J, Minami Y
Int J Mol Sci 2021 Feb 16;22(4) doi: 10.3390/ijms22041944. PMID: 33669431Free PMC Article
Treatment of Relapsed Acute Myeloid Leukemia.
Thol F, Ganser A
Curr Treat Options Oncol 2020 Jun 29;21(8):66. doi: 10.1007/s11864-020-00765-5. PMID: 32601974Free PMC Article
Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML.
DiNardo CD, Tiong IS, Quaglieri A, MacRaild S, Loghavi S, Brown FC, Thijssen R, Pomilio G, Ivey A, Salmon JM, Glytsou C, Fleming SA, Zhang Q, Ma H, Patel KP, Kornblau SM, Xu Z, Chua CC, Chen X, Blombery P, Flensburg C, Cummings N, Aifantis I, Kantarjian H, Huang DCS, Roberts AW, Majewski IJ, Konopleva M, Wei AH
Blood 2020 Mar 12;135(11):791-803. doi: 10.1182/blood.2019003988. PMID: 31932844Free PMC Article
Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges.
Shallis RM, Wang R, Davidoff A, Ma X, Zeidan AM
Blood Rev 2019 Jul;36:70-87. Epub 2019 Apr 29 doi: 10.1016/j.blre.2019.04.005. PMID: 31101526

Clinical prediction guides

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML.
Stahl M, Menghrajani K, Derkach A, Chan A, Xiao W, Glass J, King AC, Daniyan AF, Famulare C, Cuello BM, Horvat TZ, Abdel-Wahab O, Levine RL, Viny AD, Stein EM, Cai SF, Roshal M, Tallman MS, Goldberg AD
Blood Adv 2021 Mar 9;5(5):1552-1564. doi: 10.1182/bloodadvances.2020003734. PMID: 33687434Free PMC Article
Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia.
Uy GL, Aldoss I, Foster MC, Sayre PH, Wieduwilt MJ, Advani AS, Godwin JE, Arellano ML, Sweet KL, Emadi A, Ravandi F, Erba HP, Byrne M, Michaelis L, Topp MS, Vey N, Ciceri F, Carrabba MG, Paolini S, Huls GA, Jongen-Lavrencic M, Wermke M, Chevallier P, Gyan E, Récher C, Stiff PJ, Pettit KM, Löwenberg B, Church SE, Anderson E, Vadakekolathu J, Santaguida M, Rettig MP, Muth J, Curtis T, Fehr E, Guo K, Zhao J, Bakkacha O, Jacobs K, Tran K, Kaminker P, Kostova M, Bonvini E, Walter RB, Davidson-Moncada JK, Rutella S, DiPersio JF
Blood 2021 Feb 11;137(6):751-762. doi: 10.1182/blood.2020007732. PMID: 32929488Free PMC Article
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960

Recent systematic reviews

Efficacy and safety of FDA-approved IDH inhibitors in the treatment of IDH mutated acute myeloid leukemia: a systematic review and meta-analysis.
Chen X, Xing H, Xie X, Kou L, Li J, Li Y
Clin Epigenetics 2023 Jul 11;15(1):113. doi: 10.1186/s13148-023-01529-2. PMID: 37434249Free PMC Article
Outcomes with chimeric antigen receptor t-cell therapy in relapsed or refractory acute myeloid leukemia: a systematic review and meta-analysis.
Shahzad M, Nguyen A, Hussain A, Ammad-Ud-Din M, Faisal MS, Tariq E, Ali F, Butt A, Anwar I, Chaudhary SG, Lutfi F, Ahmed N, Singh AK, Hematti P, McGuirk JP, Mushtaq MU
Front Immunol 2023;14:1152457. Epub 2023 Apr 24 doi: 10.3389/fimmu.2023.1152457. PMID: 37168849Free PMC Article
The efficacy and safety of venetoclax and azacytidine combination treatment in patients with acute myeloid leukemia and myelodysplastic syndrome: systematic review and meta-analysis.
Du Y, Li C, Yan J
Hematology 2023 Dec;28(1):2198098. doi: 10.1080/16078454.2023.2198098. PMID: 37036307
Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association.
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
Efficacy of non-intensive therapies approved for relapsed/refractory acute myeloid leukemia: a systematic literature review.
Russell-Smith TA, Gurskyte L, Muresan B, Mamolo CM, Gezin A, Cappelleri JC, Heeg B
Future Oncol 2022 May;18(16):2029-2039. Epub 2022 Feb 24 doi: 10.2217/fon-2021-1355. PMID: 35196866

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