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Metastatic Endometrial Adenosquamous Carcinoma

MedGen UID:
1779004
•Concept ID:
C5446648
•
Neoplastic Process

Definition

Endometrial adenosquamous carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Endometrial Adenosquamous Carcinoma

Professional guidelines

PubMed

Adjuvant high dose rate vaginal brachytherapy as treatment of stage I and II endometrial carcinoma.
Horowitz NS, Peters WA 3rd, Smith MR, Drescher CW, Atwood M, Mate TP
Obstet Gynecol 2002 Feb;99(2):235-40. doi: 10.1016/s0029-7844(01)01672-6. PMID: 11814503
Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications.
Layfield LJ, Cramer H, Madden J, Gopez EV, Liu K
Diagn Cytopathol 2001 Jul;25(1):38-42. doi: 10.1002/dc.1099. PMID: 11466811
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions.
Hayes MM, Matisic JP, Chen CJ, Mohamed A, Anderson GH, LeRiche JC, Amy R
Cytopathology 1997 Dec;8(6):397-408. doi: 10.1111/j.1365-2303.1997.tb00570.x. PMID: 9439892

Recent clinical studies

Etiology

Lymphatic mapping in endometrial cancer: comparison of hysteroscopic and subserosal injection and the distribution of sentinel lymph nodes.
Robova H, Charvat M, Strnad P, Hrehorcak M, Taborska K, Skapa P, Rob L
Int J Gynecol Cancer 2009 Apr;19(3):391-4. doi: 10.1111/IGC.0b013e3181a1c0b1. PMID: 19407565
Pathologic stage I-II endometrial carcinoma in the elderly: radiotherapy indications and outcome.
Citron JR, Sutton H, Yamada SD, Mehta N, Mundt AJ
Int J Radiat Oncol Biol Phys 2004 Aug 1;59(5):1432-8. doi: 10.1016/j.ijrobp.2004.01.014. PMID: 15275729
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524
A clinical and pathologic study on para-aortic lymph node metastasis in endometrial carcinoma.
Hirahatake K, Hareyama H, Sakuragi N, Nishiya M, Makinoda S, Fujimoto S
J Surg Oncol 1997 Jun;65(2):82-7. doi: 10.1002/(sici)1096-9098(199706)65:2<82::aid-jso3>3.0.co;2-j. PMID: 9209518
Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases.
Ulbright TM, Roth LM
Hum Pathol 1985 Jan;16(1):28-34. doi: 10.1016/s0046-8177(85)80210-0. PMID: 2982713

Diagnosis

Clinical significance of a cytologic diagnosis of atypical glandular cells of undetermined significance.
Cheng RF, Hernandez E, Anderson LL, Heller PB, Shank R
J Reprod Med 1999 Nov;44(11):922-8. PMID: 10589401
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions.
Hayes MM, Matisic JP, Chen CJ, Mohamed A, Anderson GH, LeRiche JC, Amy R
Cytopathology 1997 Dec;8(6):397-408. doi: 10.1111/j.1365-2303.1997.tb00570.x. PMID: 9439892
Endometrial cancer in premenopausal women 45 years and younger.
Gitsch G, Hanzal E, Jensen D, Hacker NF
Obstet Gynecol 1995 Apr;85(4):504-8. doi: 10.1016/0029-7844(95)00001-8. PMID: 7898824
Cervicovaginal cytology in uterine adenocarcinoma and adenosquamous carcinoma. Comparison of cytologic and histologic findings.
Costa MJ, Kenny MB, Naib ZM
Acta Cytol 1991 Jan-Feb;35(1):127-34. PMID: 1994621
Prognostic value of pathologic features and DNA analysis in endometrial carcinoma.
Symonds DA
Gynecol Oncol 1990 Dec;39(3):272-6. doi: 10.1016/0090-8258(90)90251-f. PMID: 2258070

Therapy

Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148.
Oza AM, Eisenhauer EA, Elit L, Cutz JC, Sakurada A, Tsao MS, Hoskins PJ, Biagi J, Ghatage P, Mazurka J, Provencher D, Dore N, Dancey J, Fyles A
J Clin Oncol 2008 Sep 10;26(26):4319-25. Epub 2008 Jun 30 doi: 10.1200/JCO.2007.15.8808. PMID: 18591547
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524
Endometrial cancer in premenopausal women 45 years and younger.
Gitsch G, Hanzal E, Jensen D, Hacker NF
Obstet Gynecol 1995 Apr;85(4):504-8. doi: 10.1016/0029-7844(95)00001-8. PMID: 7898824
Preoperative radiation therapy followed by extrafascial hysterectomy in patients with stage II endometrial carcinoma.
Higgins RV, van Nagell JR Jr, Horn EJ, Roberts SL, Donaldson ES, Gallion HH, DePriest PD, Powell DE, Kryscio RJ
Cancer 1991 Sep 15;68(6):1261-4. doi: 10.1002/1097-0142(19910915)68:6<1261::aid-cncr2820680614>3.0.co;2-v. PMID: 1873779
Melphalan, 5-fluorouracil, and medroxyprogesterone acetate in metastatic or recurrent endometrial carcinoma. Preliminary report.
Piver MS, Lele S, Barlow JJ
Obstet Gynecol 1980 Sep;56(3):370-2. PMID: 7422177

Prognosis

Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma.
Salvesen HB, Stefansson I, Kalvenes MB, Das S, Akslen LA
Cancer 2002 Apr 15;94(8):2185-91. doi: 10.1002/cncr.10434. PMID: 12001116
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
Creutzberg CL, van Putten WL, Koper PC, Lybeert ML, Jobsen JJ, Wárlám-Rodenhuis CC, De Winter KA, Lutgens LC, van den Bergh AC, van de Steen-Banasik E, Beerman H, van Lent M
Lancet 2000 Apr 22;355(9213):1404-11. doi: 10.1016/s0140-6736(00)02139-5. PMID: 10791524
A clinical and pathologic study on para-aortic lymph node metastasis in endometrial carcinoma.
Hirahatake K, Hareyama H, Sakuragi N, Nishiya M, Makinoda S, Fujimoto S
J Surg Oncol 1997 Jun;65(2):82-7. doi: 10.1002/(sici)1096-9098(199706)65:2<82::aid-jso3>3.0.co;2-j. PMID: 9209518
Prognostic value of pathologic features and DNA analysis in endometrial carcinoma.
Symonds DA
Gynecol Oncol 1990 Dec;39(3):272-6. doi: 10.1016/0090-8258(90)90251-f. PMID: 2258070
Melphalan, 5-fluorouracil, and medroxyprogesterone acetate in metastatic or recurrent endometrial carcinoma. Preliminary report.
Piver MS, Lele S, Barlow JJ
Obstet Gynecol 1980 Sep;56(3):370-2. PMID: 7422177

Clinical prediction guides

Clinical and toxicity predictors of response and progression to temsirolimus in women with recurrent or metastatic endometrial cancer.
Goodwin RA, Jamal R, Tu D, Walsh W, Dancey J, Oza AM, Elit L, Eisenhauer EA
Gynecol Oncol 2013 Nov;131(2):315-20. Epub 2013 Aug 9 doi: 10.1016/j.ygyno.2013.08.004. PMID: 23938374
Prognostic significance of stromal versican expression in human endometrial cancer.
Kodama J, Hasengaowa, Kusumoto T, Seki N, Matsuo T, Ojima Y, Nakamura K, Hongo A, Hiramatsu Y
Ann Oncol 2007 Feb;18(2):269-74. Epub 2006 Oct 25 doi: 10.1093/annonc/mdl370. PMID: 17065588
Endometrial extension of adenosquamous carcinoma of the uterine cervix.
Nakao Y, Yokoyama M, Hara K, Yasunaga M, Uchiyama M, Noguchi M, Iwasaka T
Int J Gynecol Cancer 2004 Jul-Aug;14(4):625-7. doi: 10.1111/j.1048-891X.2004.14413.x. PMID: 15304157
Clinicopathological factors predicting retroperitoneal lymph node metastasis and survival in endometrial cancer.
Tang X, Tanemura K, Ye W, Ohmi K, Tsunematsu R, Yamada T, Katsumata N, Sonoda T
Jpn J Clin Oncol 1998 Nov;28(11):673-8. doi: 10.1093/jjco/28.11.673. PMID: 9861234
Prognostic value of pathologic features and DNA analysis in endometrial carcinoma.
Symonds DA
Gynecol Oncol 1990 Dec;39(3):272-6. doi: 10.1016/0090-8258(90)90251-f. PMID: 2258070

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